Polymyxin sensitivity/resistance cosmopolitan status, epidemiology and prevalence among O1/O139 and non-O1/non-O139 Vibrio cholerae : a meta-analysis

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dc.contributor.author Igere, Bright E.
dc.contributor.author Onohuean, Hope
dc.contributor.author Iwu, Chidozie Declan
dc.contributor.author Igbinosa, Etinosa O.
dc.date.accessioned 2024-07-30T10:49:43Z
dc.date.available 2024-07-30T10:49:43Z
dc.date.issued 2023
dc.description DATA AVAILABLE STATEMENT : The datasets/information used for this study are avail- able within the manuscript and the supplementary mate- rials. en_US
dc.description.abstract Resistance/sensitivity to polymyxin-B (PB) antibiotic has been employed as one among other epidemiologically relevant biotyping-scheme for Vibrio cholerae into Classical/El Tor biotypes. However, recent studies have re- vealed some pitfalls bordering on PB-sensitivity/resistance (PBR/S) necessitating study. Current study assesses the PBR/S cosmopolitan prevalence, epidemiology/distribution among O1/O139 and nonO1/nonO139 V. cholerae strains. Relevant databases (Web of Science, Scopus and PubMed) were searched to retrieve data from environ- mental and clinical samples employing the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Random-effect-model (REM) and common-effect-model (CEM) of meta-analysis was performed to de- termine prevalence of PBR/S V. cholerae strains, describe the cosmopolitan epidemiological potentials and biotype relevance. Heterogeneity was determined by meta-regression and subgroup analyses. The pooled analyzed iso- lates from articles (7290), with sensitive and resistance are 2219 (30.44%) and 5028 (69.56%). Among these PB- sensitive strains, more than 1944 (26.67%) were O1 strains, 132 (1.81%) were nonO1 strains while mis-reported Classical biotype were 2080 (28.53) respectively indicating potential spread of variant/dual biotype. A significant PB-resistance was observed in the models (CEM = 0.66, 95% CI [0.65; 0.68], p -value = 0.001; REM = 0.83 [0.74; 0.90], p = 0.001) as both models had a high level of heterogeneity ( I2 = 98.0%; 2 =33 = 1755 . 09 , = 2 . 4932 ). Egger test ( z = 5.4017, p < 0.0001) reveal publication bias by funnel plot asymmetry. The subgroup analysis for continents (Asia, Africa) and sources (acute diarrhea) revealed (98% CI (0.73; 0.93); 55% CI (0.20; 0.86)), and 92% CI (0.67; 0.98). The Epidemiological prevalence for El tor/variant/dual biotype showed 88% CI (0.78; 0.94) with O1 strains at 88% CI (0.78; 0.94). Such global prevalence, distribution/spread of phenotypes/genotypes ne- cessitates updating the decades-long biotype classification scheme. An antibiotic stewardship in the post antibiotic era is suggestive/recommended. Also, there is need for holistic monitoring/evaluation of clinical/epidemiological relevance of the disseminating strains in endemic localities. en_US
dc.description.department Microbiology and Plant Pathology en_US
dc.description.librarian am2024 en_US
dc.description.sdg SDG-03:Good heatlh and well-being en_US
dc.description.sponsorship African German Network of Excellence in Science 2022. en_US
dc.description.uri www.elsevier.com/locate/imj en_US
dc.description.uri http://www.elsevier.com/locate/imj en_US
dc.identifier.citation Igere, B.E., Onohuean, H., Iwu, D.C. 2023, 'Polymyxin sensitivity/resistance cosmopolitan status, epidemiology and prevalence among O1/O139 and non-O1/non-O139 Vibrio cholerae : a meta-analysis', Infectious Medicine, vol. 2, no. 4, pp. 283-293. https://DOI.org/10.1016/j.imj.2023.11.004. en_US
dc.identifier.issn 2772-431X
dc.identifier.other 10.1016/j.imj.2023.11.004
dc.identifier.uri http://hdl.handle.net/2263/97329
dc.language.iso en en_US
dc.publisher Elsevier en_US
dc.rights © 2023 The Author(s). This is an open access article under the CC BY license. en_US
dc.subject Biotyping scheme en_US
dc.subject Environmental nonO1/nonO139 V. cholerae en_US
dc.subject Clinical O1/O139 V. cholerae en_US
dc.subject PB-sensitive/PB-resistant strains en_US
dc.subject Global epidemiological relevance en_US
dc.subject Polymyxin B en_US
dc.subject SDG-03: Good health and well-being en_US
dc.title Polymyxin sensitivity/resistance cosmopolitan status, epidemiology and prevalence among O1/O139 and non-O1/non-O139 Vibrio cholerae : a meta-analysis en_US
dc.type Article en_US


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