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dc.contributor.author | Igere, Bright E.![]() |
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dc.contributor.author | Onohuean, Hope![]() |
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dc.contributor.author | Iwu, Chidozie Declan![]() |
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dc.contributor.author | Igbinosa, Etinosa O.![]() |
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dc.date.accessioned | 2024-07-30T10:49:43Z | |
dc.date.available | 2024-07-30T10:49:43Z | |
dc.date.issued | 2023 | |
dc.description | DATA AVAILABLE STATEMENT : The datasets/information used for this study are avail- able within the manuscript and the supplementary mate- rials. | en_US |
dc.description.abstract | Resistance/sensitivity to polymyxin-B (PB) antibiotic has been employed as one among other epidemiologically relevant biotyping-scheme for Vibrio cholerae into Classical/El Tor biotypes. However, recent studies have re- vealed some pitfalls bordering on PB-sensitivity/resistance (PBR/S) necessitating study. Current study assesses the PBR/S cosmopolitan prevalence, epidemiology/distribution among O1/O139 and nonO1/nonO139 V. cholerae strains. Relevant databases (Web of Science, Scopus and PubMed) were searched to retrieve data from environ- mental and clinical samples employing the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Random-effect-model (REM) and common-effect-model (CEM) of meta-analysis was performed to de- termine prevalence of PBR/S V. cholerae strains, describe the cosmopolitan epidemiological potentials and biotype relevance. Heterogeneity was determined by meta-regression and subgroup analyses. The pooled analyzed iso- lates from articles (7290), with sensitive and resistance are 2219 (30.44%) and 5028 (69.56%). Among these PB- sensitive strains, more than 1944 (26.67%) were O1 strains, 132 (1.81%) were nonO1 strains while mis-reported Classical biotype were 2080 (28.53) respectively indicating potential spread of variant/dual biotype. A significant PB-resistance was observed in the models (CEM = 0.66, 95% CI [0.65; 0.68], p -value = 0.001; REM = 0.83 [0.74; 0.90], p = 0.001) as both models had a high level of heterogeneity ( I2 = 98.0%; 2 =33 = 1755 . 09 , = 2 . 4932 ). Egger test ( z = 5.4017, p < 0.0001) reveal publication bias by funnel plot asymmetry. The subgroup analysis for continents (Asia, Africa) and sources (acute diarrhea) revealed (98% CI (0.73; 0.93); 55% CI (0.20; 0.86)), and 92% CI (0.67; 0.98). The Epidemiological prevalence for El tor/variant/dual biotype showed 88% CI (0.78; 0.94) with O1 strains at 88% CI (0.78; 0.94). Such global prevalence, distribution/spread of phenotypes/genotypes ne- cessitates updating the decades-long biotype classification scheme. An antibiotic stewardship in the post antibiotic era is suggestive/recommended. Also, there is need for holistic monitoring/evaluation of clinical/epidemiological relevance of the disseminating strains in endemic localities. | en_US |
dc.description.department | Microbiology and Plant Pathology | en_US |
dc.description.librarian | am2024 | en_US |
dc.description.sdg | SDG-03:Good heatlh and well-being | en_US |
dc.description.sponsorship | African German Network of Excellence in Science 2022. | en_US |
dc.description.uri | www.elsevier.com/locate/imj | en_US |
dc.description.uri | http://www.elsevier.com/locate/imj | en_US |
dc.identifier.citation | Igere, B.E., Onohuean, H., Iwu, D.C. 2023, 'Polymyxin sensitivity/resistance cosmopolitan status, epidemiology and prevalence among O1/O139 and non-O1/non-O139 Vibrio cholerae : a meta-analysis', Infectious Medicine, vol. 2, no. 4, pp. 283-293. https://DOI.org/10.1016/j.imj.2023.11.004. | en_US |
dc.identifier.issn | 2772-431X | |
dc.identifier.other | 10.1016/j.imj.2023.11.004 | |
dc.identifier.uri | http://hdl.handle.net/2263/97329 | |
dc.language.iso | en | en_US |
dc.publisher | Elsevier | en_US |
dc.rights | © 2023 The Author(s). This is an open access article under the CC BY license. | en_US |
dc.subject | Biotyping scheme | en_US |
dc.subject | Environmental nonO1/nonO139 V. cholerae | en_US |
dc.subject | Clinical O1/O139 V. cholerae | en_US |
dc.subject | PB-sensitive/PB-resistant strains | en_US |
dc.subject | Global epidemiological relevance | en_US |
dc.subject | Polymyxin B | en_US |
dc.subject | SDG-03: Good health and well-being | en_US |
dc.title | Polymyxin sensitivity/resistance cosmopolitan status, epidemiology and prevalence among O1/O139 and non-O1/non-O139 Vibrio cholerae : a meta-analysis | en_US |
dc.type | Article | en_US |