Tryptophan end-tagging confers antifungal activity on a tick-derived peptide by triggering reactive oxygen species production
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| dc.contributor.author | Chiramba, Court Kudakwashe
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| dc.contributor.author | Moller, Dalton Sharl
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| dc.contributor.author | Lorenz, Christian D.
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| dc.contributor.author | Chirombo, Rumbidzai Ruth
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| dc.contributor.author | Mason, A. James
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| dc.contributor.author | Bester, Megan Jean
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| dc.contributor.author | Gaspar, Anabella Regina Marques
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| dc.date.accessioned | 2024-07-25T07:57:57Z | |
| dc.date.available | 2024-07-25T07:57:57Z | |
| dc.date.issued | 2024-03 | |
| dc.description | DATA AVAILABILITY STATEMENT : All data supporting the findings of this study are available in the figures and Supporting Information. | en_US |
| dc.description | SUPPLEMENTARY MATERIAL : Effect of antifungal agents on cell growth and viability; biofilm preventing activity of AMB, Os−C, and Os− C(W5); biofilm eradicating activity of AMB and Os− C(W5); microscopy images of cells exposed to AMB; and HPLC and MS data for Os−C and Os−C(W5). | en_US |
| dc.description.abstract | Please read abstract in the article. | en_US |
| dc.description.department | Anatomy | en_US |
| dc.description.department | Biochemistry | en_US |
| dc.description.department | Genetics | en_US |
| dc.description.department | Microbiology and Plant Pathology | en_US |
| dc.description.librarian | hj2024 | en_US |
| dc.description.sdg | SDG-03:Good heatlh and well-being | en_US |
| dc.description.sponsorship | The National Research Foundation, the University of Pretoria, the SA-UK Newton Fund Antibiotic Accelerator administered by the Medical Research Council (MRC) and the South African Medical Research Council (SAMRC), the UK Materials and Molecular Modelling Hub which is partially funded by EPSRC and and the UK HPC Materials Chemistry Consortium, which is also funded by EPSRC. | en_US |
| dc.description.uri | https://pubs.acs.org/journal/acsodf | en_US |
| dc.identifier.citation | Chiramba, C.K., Möller, D.S., Lorenz, C.D. et al. 2024, 'Tryptophan end-tagging confers antifungal activity on a tick-derived peptide by triggering reactive oxygen species production', ACS Omega, vol. 9, no. 13, pp. 15556–15572, doi : 10.1021/acsomega.4c00478. | en_US |
| dc.identifier.issn | 2470-1343 (online) | |
| dc.identifier.other | 10.1021/acsomega.4c00478 | |
| dc.identifier.uri | http://hdl.handle.net/2263/97229 | |
| dc.language.iso | en | en_US |
| dc.publisher | American Chemical Society | en_US |
| dc.rights | © 2024 The Authors. Published by American Chemical Society. This article is licensed under CC-BY-NC-ND 4.0. | en_US |
| dc.subject | Biofilms | en_US |
| dc.subject | Membranes | en_US |
| dc.subject | Monomers | en_US |
| dc.subject | Peptides and proteins | en_US |
| dc.subject | Vesicles | en_US |
| dc.subject | Antimicrobial peptide (AMP) | en_US |
| dc.subject | Tryptophan end-tagging | en_US |
| dc.subject | Antifungal activity | en_US |
| dc.subject | Physiological salt environments | en_US |
| dc.subject | SDG-03: Good health and well-being | en_US |
| dc.title | Tryptophan end-tagging confers antifungal activity on a tick-derived peptide by triggering reactive oxygen species production | en_US |
| dc.type | Article | en_US |
