Acaricide resistance status of livestock ticks from East and West Africa and in vivo efficacy of acaricides to control them

Show simple item record

dc.contributor.author Evans, Alec
dc.contributor.author Madder, Maxime
dc.contributor.author Fourie, Josephus
dc.contributor.author Halos, Lénaïg
dc.contributor.author Kumsa, Bersissa
dc.contributor.author Kimbita, Elikira
dc.contributor.author Byaruhanga, Joseph
dc.contributor.author Mwiine, Frank Norbert
dc.contributor.author Muhanguzi, Dennis
dc.contributor.author Adehan, Safiou Bienvenu
dc.contributor.author Toure, Alassane
dc.contributor.author Nzalawahe, Jahashi
dc.contributor.author Aboagye-Antwi, Fred
dc.contributor.author Ogo, Ndudim Isaac
dc.contributor.author Meyer, Leon
dc.contributor.author Jongejan, Frans
dc.contributor.author Cheikhi, Imad Bouzaidi
dc.contributor.author Fisher, Maggie
dc.contributor.author Holdsworth, Peter
dc.date.accessioned 2024-06-21T06:43:36Z
dc.date.available 2024-06-21T06:43:36Z
dc.date.issued 2024-08
dc.description.abstract Through a collaborative effort across six Sub-Saharan African countries, using recognized international assessment techniques, 23 stocks of three tick species (Rhipicephalus microplus, Rhipicephalus appendiculatus and Amblyomma variegatum) of economic importance for rural small holder farming communities from East and West Africa were collected from cattle, and evaluated in in vitro larval packet tests (LPT). The results demonstrated medium to high resistance to chlorfenvinphos and amitraz across species. Rhipicephalus microplus demonstrated high level alpha-cypermethrin and cypermethrin resistance. Stocks of A. variegatum (West Africa) and R. appendiculatus (Uganda) demonstrated medium level ivermectin resistance. The four least susceptible stocks (East and West African R. microplus, A. variegatum and R. appendiculatus) were taken into in vivo controlled cattle studies where fipronil was found effective against West and East African R. microplus isolates although persistent efficacy failed to reach 90%. Cymiazole and cypermethrin, and ivermectin based acaricides were partially effective against R. microplus without persistent efficacy. Flumethrin spray-on killed A. variegatum within 72 h for up to 10 days posttreatment, however product application was directly to tick attachment sites, which may be impractical under field conditions. A flumethrin pour-on formulation on goats provided persistent efficacy against A. variegatum for up to one-month. Therapeutic control was achieved against R. appendiculatus through weekly spraying cattle with flumethrin, amitraz or combined cymiazole and cypermethrin. A fipronil pour-on product offered four-week residual control against R. appendiculatus (with slow onset of action). Few studies have assessed and directly compared acaricidal activity in vitro and in vivo. There was some discordance between efficacy indicated by LPT and in vivo results. This observation calls for more research into accurate and affordable assessment methods for acaricide resistance. No single active or product was effective against all three tick species, emphasising the need for the development of alternative integrated tick management solutions. en_US
dc.description.department Veterinary Tropical Diseases en_US
dc.description.librarian hj2024 en_US
dc.description.sdg SDG-02:Zero Hunger en_US
dc.description.sdg SDG-03:Good heatlh and well-being en_US
dc.description.sponsorship The BMGF and a Bill & Melinda Gates Foundation (BMGF) supported project. en_US
dc.description.uri https://www.elsevier.com/locate/ijpddr en_US
dc.identifier.citation Evans, A., Madder, M., Fourie, J. et al. 2024, 'Acaricide resistance status of livestock ticks from East and West Africa and in vivo efficacy of acaricides to control them', International Journal for Parasitology: Drugs and Drug Resistance, vol. 25, art. 100541, pp. 1-11, doi : 10.1016/j.ijpddr.2024.100541. en_US
dc.identifier.issn 2211-3207 (online)
dc.identifier.other 10.1016/j.ijpddr.2024.100541.
dc.identifier.uri http://hdl.handle.net/2263/96574
dc.language.iso en en_US
dc.publisher Elsevier en_US
dc.rights © 2024 The Authors. Published by Elsevier Ltd on behalf of Australian Society for Parasitology. This is an open access article under the CC BY license. en_US
dc.subject Ruminant en_US
dc.subject Amblyomma variegatum en_US
dc.subject Rhipicephalus appendiculatus en_US
dc.subject Rhipicephalus microplus en_US
dc.subject Efficacy en_US
dc.subject Acaricide resistance en_US
dc.subject Sub-Saharan Africa (SSA) en_US
dc.subject Tick stocks en_US
dc.subject SDG-03: Good health and well-being en_US
dc.subject SDG-02: Zero hunger en_US
dc.title Acaricide resistance status of livestock ticks from East and West Africa and in vivo efficacy of acaricides to control them en_US
dc.type Article en_US


Files in this item

This item appears in the following Collection(s)

Show simple item record