dc.contributor.author |
Jassat, Waasila
|
|
dc.contributor.author |
Karim, Salim S. Abdool
|
|
dc.contributor.author |
Ozougwu, Lovelyn
|
|
dc.contributor.author |
Welch, Richard
|
|
dc.contributor.author |
Mudara, Caroline
|
|
dc.contributor.author |
Masha, Maureen
|
|
dc.contributor.author |
Rousseau, Petro
|
|
dc.contributor.author |
Wolmarans, Milani
|
|
dc.contributor.author |
Selikow, Anthony
|
|
dc.contributor.author |
Govender, Nevashan
|
|
dc.contributor.author |
Walaza, sibongile
|
|
dc.contributor.author |
Von Gottberg, Anne
|
|
dc.contributor.author |
Wolter, Nicole
|
|
dc.contributor.author |
Groome, Michelle J.
|
|
dc.contributor.author |
Pisa, Pedro Terrence
|
|
dc.contributor.author |
Sanne, Ian
|
|
dc.contributor.author |
Govender, Sharlene
|
|
dc.contributor.author |
Cohen, Cheryl
|
|
dc.contributor.author |
Groome, Michelle J.
|
|
dc.date.accessioned |
2024-04-24T10:08:38Z |
|
dc.date.available |
2024-04-24T10:08:38Z |
|
dc.date.issued |
2023-04-15 |
|
dc.description.abstract |
BACKGROUND : In this study, we compared admission incidence risk and the risk of mortality in the Omicron BA.4/BA.5 wave to
previous waves.
METHODS : Data from South Africa’s SARS-CoV-2 case linelist, national COVID-19 hospital surveillance system, and Electronic
Vaccine Data System were linked and analyzed. Wave periods were defined when the country passed a weekly incidence of 30 cases/
100 000 population. In-hospital case fatality ratios (CFRs) during the Delta, Omicron BA.1/BA.2, and Omicron BA.4/BA.5 waves
were compared using post-imputation random effect multivariable logistic regression models.
RESULTS : The CFR was 25.9% (N=37 538 of 144 778), 10.9% (N=6123 of 56 384), and 8.2% (N=1212 of 14 879) in the Delta,
Omicron BA.1/BA.2, and Omicron BA.4/BA.5 waves, respectively. After adjusting for age, sex, race, comorbidities, health sector,
and province, compared with the Omicron BA.4/BA.5 wave, patients had higher risk of mortality in the Omicron BA.1/BA.2 wave
(adjusted odds ratio [aOR], 1.3; 95% confidence interval [CI]: 1.2–1.4) and Delta wave (aOR, 3.0; 95% CI: 2.8–3.2). Being partially
vaccinated (aOR, 0.9; 95% CI: .9–.9), fully vaccinated (aOR, 0.6; 95% CI: .6–.7), and boosted (aOR, 0.4; 95% CI: .4–.5) and having
prior laboratory-confirmed infection (aOR, 0.4; 95% CI: .3–.4) were associated with reduced risks of mortality.
CONCLUSIONS : Overall, admission incidence risk and in-hospital mortality, which had increased progressively in South Africa’s
first 3 waves, decreased in the fourth Omicron BA.1/BA.2 wave and declined even further in the fifth Omicron BA.4/BA.5 wave.
Mortality risk was lower in those with natural infection and vaccination, declining further as the number of vaccine doses increased. |
en_US |
dc.description.department |
Human Nutrition |
en_US |
dc.description.librarian |
am2024 |
en_US |
dc.description.sdg |
SDG-03:Good heatlh and well-being |
en_US |
dc.description.uri |
https://academic.oup.com/cid/ |
en_US |
dc.identifier.citation |
Jassat, W., Karim, S.S.A., Ozougwu, L. et al. 2023, 'Trends in cases, hospitalizations, and mortality related to the Omicron BA.4/BA.5 subvariants in South Africa', Clinical Infectious Diseases, vol. 76, no. 8, pp. 1468-1475. https://DOI.org/10.1093/cid/ciac921. |
en_US |
dc.identifier.issn |
1058-4838 (print) |
|
dc.identifier.issn |
1537-6591 (online) |
|
dc.identifier.other |
10.1093/cid/ciac921 |
|
dc.identifier.uri |
http://hdl.handle.net/2263/95743 |
|
dc.language.iso |
en |
en_US |
dc.publisher |
Oxford University Press |
en_US |
dc.rights |
© The Author(s) 2022.
This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence. |
en_US |
dc.subject |
Hospital admissions |
en_US |
dc.subject |
Mortality |
en_US |
dc.subject |
Omicron BA.4 |
en_US |
dc.subject |
Omicron BA.5. |
en_US |
dc.subject |
COVID-19 pandemic |
en_US |
dc.subject |
Coronavirus disease 2019 (COVID-19) |
en_US |
dc.subject |
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) |
en_US |
dc.subject |
SDG-03: Good health and well-being |
en_US |
dc.title |
Trends in cases, hospitalizations, and mortality related to the Omicron BA.4/BA.5 subvariants in South Africa |
en_US |
dc.type |
Article |
en_US |