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dc.contributor.author | Jassat, Waasila![]() |
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dc.contributor.author | Karim, Salim S. Abdool![]() |
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dc.contributor.author | Ozougwu, Lovelyn![]() |
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dc.contributor.author | Welch, Richard![]() |
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dc.contributor.author | Mudara, Caroline![]() |
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dc.contributor.author | Masha, Maureen![]() |
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dc.contributor.author | Rousseau, Petro![]() |
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dc.contributor.author | Wolmarans, Milani![]() |
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dc.contributor.author | Selikow, Anthony![]() |
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dc.contributor.author | Govender, Nevashan![]() |
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dc.contributor.author | Walaza, sibongile![]() |
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dc.contributor.author | Von Gottberg, Anne![]() |
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dc.contributor.author | Wolter, Nicole![]() |
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dc.contributor.author | Groome, Michelle J.![]() |
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dc.contributor.author | Pisa, Pedro Terrence![]() |
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dc.contributor.author | Sanne, Ian![]() |
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dc.contributor.author | Govender, Sharlene![]() |
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dc.contributor.author | Cohen, Cheryl![]() |
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dc.contributor.author | Groome, Michelle J.![]() |
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dc.date.accessioned | 2024-04-24T10:08:38Z | |
dc.date.available | 2024-04-24T10:08:38Z | |
dc.date.issued | 2023-04-15 | |
dc.description.abstract | BACKGROUND : In this study, we compared admission incidence risk and the risk of mortality in the Omicron BA.4/BA.5 wave to previous waves. METHODS : Data from South Africa’s SARS-CoV-2 case linelist, national COVID-19 hospital surveillance system, and Electronic Vaccine Data System were linked and analyzed. Wave periods were defined when the country passed a weekly incidence of 30 cases/ 100 000 population. In-hospital case fatality ratios (CFRs) during the Delta, Omicron BA.1/BA.2, and Omicron BA.4/BA.5 waves were compared using post-imputation random effect multivariable logistic regression models. RESULTS : The CFR was 25.9% (N=37 538 of 144 778), 10.9% (N=6123 of 56 384), and 8.2% (N=1212 of 14 879) in the Delta, Omicron BA.1/BA.2, and Omicron BA.4/BA.5 waves, respectively. After adjusting for age, sex, race, comorbidities, health sector, and province, compared with the Omicron BA.4/BA.5 wave, patients had higher risk of mortality in the Omicron BA.1/BA.2 wave (adjusted odds ratio [aOR], 1.3; 95% confidence interval [CI]: 1.2–1.4) and Delta wave (aOR, 3.0; 95% CI: 2.8–3.2). Being partially vaccinated (aOR, 0.9; 95% CI: .9–.9), fully vaccinated (aOR, 0.6; 95% CI: .6–.7), and boosted (aOR, 0.4; 95% CI: .4–.5) and having prior laboratory-confirmed infection (aOR, 0.4; 95% CI: .3–.4) were associated with reduced risks of mortality. CONCLUSIONS : Overall, admission incidence risk and in-hospital mortality, which had increased progressively in South Africa’s first 3 waves, decreased in the fourth Omicron BA.1/BA.2 wave and declined even further in the fifth Omicron BA.4/BA.5 wave. Mortality risk was lower in those with natural infection and vaccination, declining further as the number of vaccine doses increased. | en_US |
dc.description.department | Human Nutrition | en_US |
dc.description.librarian | am2024 | en_US |
dc.description.sdg | SDG-03:Good heatlh and well-being | en_US |
dc.description.uri | https://academic.oup.com/cid/ | en_US |
dc.identifier.citation | Jassat, W., Karim, S.S.A., Ozougwu, L. et al. 2023, 'Trends in cases, hospitalizations, and mortality related to the Omicron BA.4/BA.5 subvariants in South Africa', Clinical Infectious Diseases, vol. 76, no. 8, pp. 1468-1475. https://DOI.org/10.1093/cid/ciac921. | en_US |
dc.identifier.issn | 1058-4838 (print) | |
dc.identifier.issn | 1537-6591 (online) | |
dc.identifier.other | 10.1093/cid/ciac921 | |
dc.identifier.uri | http://hdl.handle.net/2263/95743 | |
dc.language.iso | en | en_US |
dc.publisher | Oxford University Press | en_US |
dc.rights | © The Author(s) 2022. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence. | en_US |
dc.subject | Hospital admissions | en_US |
dc.subject | Mortality | en_US |
dc.subject | Omicron BA.4 | en_US |
dc.subject | Omicron BA.5. | en_US |
dc.subject | COVID-19 pandemic | en_US |
dc.subject | Coronavirus disease 2019 (COVID-19) | en_US |
dc.subject | Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) | en_US |
dc.subject | SDG-03: Good health and well-being | en_US |
dc.subject.other | Health sciences articles SDG-03 | |
dc.subject.other | SDG-03: Good health and well-being | |
dc.title | Trends in cases, hospitalizations, and mortality related to the Omicron BA.4/BA.5 subvariants in South Africa | en_US |
dc.type | Article | en_US |