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Research Articles (Veterinary Genetics Laboratory): Recent submissions

  • Poaching forensics : animal victims in the courtroom 
    Harper, Cindy Kim (Annual Reviews, 2023)
    Poaching and the international trade in wildlife are escalating problems driven by poverty and greed and coordinated by increasingly sophisticated criminal networks. Biodiversity loss, caused by habitat change, is ...
  • High diversity, inbreeding and a dynamic Pleistocene demographic history revealed by African buffalo genomes 
    De Jager, Deon; Glanzmann, Brigitte; Möller, Marlo; Hoal, Eileen; Van Helden, Paul; Harper, Cindy Kim; Bloomer, Paulette (Nature Research, 2021)
    Genomes retain records of demographic changes and evolutionary forces that shape species and populations. Remnant populations of African bufalo (Syncerus cafer) in South Africa, with varied histories, provide an opportunity ...
  • Polygamous farmed Nile crocodiles (Crocodylus niloticus) : foetal membranes tell the story 
    Nothling, Johan Oliviette; Nothling, Johan Antowan; Myburgh, Jan G.; Harper, Cindy Kim (AOSIS Open Journals, 2020-11-06)
    Multiple paternity in crocodilian broods would increase effective population size and slow down the loss of genetic variation due to inbreeding and random genetic drift in real populations. Multiple paternity may also ...
  • Genetic diversity, relatedness and inbreeding of ranched and fragmented Cape buffalo populations in southern Africa 
    De Jager, G.J. (Deon); Harper, Cindy Kim; Bloomer, Paulette (Public Library of Science, 2020-08-14)
    Wildlife ranching, although not considered a conventional conservation system, provides a sustainable model for wildlife utilization and could be a source of valuable genetic material. However, increased fragmentation ...
  • Anthropogenic movement results in hybridisation in impala in southern Africa 
    Miller, Susan M.; Moeller, Carl-Heinz; Harper, Cindy Kim; Bloomer, Paulette (Springer, 2020-08)
    Hybridisation caused by anthropogenic movements of animals is a conservation concern. Black-faced impala (Aepyceros melampus petersi) are endemic to north-western Namibia and south-western Angola and are geographically ...
  • Genetic rescue of an isolated African lion population 
    Miller, Susan M.; Druce, Dave J.; Dalton, Desire L.; Harper, Cindy Kim; Kotze, Antoinette; Packer, Craig; Slotow, Rob; Bloomer, Paulette (Springer, 2020-02)
    Fragmented wildlife populations are challenged by limited gene flow that can lead to significant inbreeding. The lion (Panthera leo) population in South Africa’s Hluhluwe-iMfolozi Park (HiP) started from a small founder ...
  • Robust forensic matching of confiscated horns to individual poached African rhinoceros 
    Harper, Cindy Kim; Ludwig, Anette; Clarke, Amy B.; Makgopela, Kagiso; Yurchenko, Andrey; Guthrie, Alan John; Dobrynin, Pavel; Tamazian, Gaik; Emslie, Richard; Van Heerden, Marile; Hofmeyr, Markus; Potter, Roderick; Roets, Johannes; Beytell, Piet; Otiende, Moses; Kariuki, Linus; Du Toit, Raoul; Anderson, Natasha; Okori, Joseph; Antonik, Alexey; Koepfli, Klaus-Peter; Thompson, P.N. (Peter N.); O’Brien, Stephen J. (Elsevier (Cell Press), 2018)
    Black and white rhinoceros (Diceros bicornis and Ceratotherium simum) are iconic African species that are classified by the International Union for the Conservation of Nature (IUCN) as Critically Endangered and ...
  • Friends and family : a software program for identification of unrelated individuals from molecular marker data 
    De Jager, G.J. (Deon); Swarts, Petrus; Harper, Cindy Kim; Bloomer, Paulette (Wiley, 2017-11)
    The identification of related and unrelated individuals from molecular marker data is often difficult, particularly when no pedigree information is available and the data set is large. High levels of relatedness or inbreeding ...
  • Specifying and sustaining pigmentation patterns in domestic and wild cats 
    Kaelin, Christopher B.; Xu, Xiao; Hong, Lewis Z.; David, Victor A.; McGowan, Kelly A.; Schmidt-Küntzel, Anne; Roelke, Melody E.; Pino, Javier; Pontius, Joan; Cooper, Gregory M.; Manuel, Hermogenes; Swanson, William F.; Marker, Laurie; Harper, Cindy Kim; Van Dyk, Ann; Yue, Bisong; Mullikin, James C.; Warren, Wesley C.; Eizirik, Eduardo; Kos, Lidia; O’Brien, Stephen J.; Barsh, Gregory S.; Menotti-Raymond, Marilyn (American Association for the Advancement of Science, 2012-09)
    Color markings among felid species display both a remarkable diversity and a common underlying periodicity. A similar range of patterns within domestic cats suggests a conserved mechanism whose appearance can be altered ...
  • Missense mutation in the ligand-binding domain of the horse androgen receptor gene in a thoroughbred family with inherited 64,XY (SRY+) disorder of sex development 
    Bolzon, Colin; Joone, C.J. (Carolynne); Schulman, M.L. (Martin); Harper, Cindy Kim; Villagómez, Daniel A.F.; King, W. Allan; Révay, Tamas (Karger, 2016)
    Disorders of sex development (DSD) have long been documented in domestic animal species including horses. However, there is only a single report of an androgen receptor mutation causative of such a DSD syndrome in a horse ...
  • Evaluation of microsatellites for common ungulates in the South African wildlife industry 
    Miller, Susan M.; Clarke, Amy B.; Bloomer, Paulette; Guthrie, Alan John; Harper, Cindy Kim (Springer, 2016-09)
    Wildlife is a multi-million dollar industry in South Africa ranging from intensively farmed animals on small properties to free-roaming animals in large functional ecosystems. Specific concerns surrounding the ...
  • Single base-pair deletion in ASIP exon 3 associated with recessive black phenotype in impala (Aepyceros melampus) 
    Miller, Susan M.; Guthrie, Alan John; Harper, Cindy Kim (Wiley, 2016-08)
    No abstract is available.
  • Fenced and fragmented : conservation value of managed metapopulations 
    Miller, Susan M.; Harper, Cindy Kim; Bloomer, Paulette; Hofmeyr, Jennifer; Funston, Paul J. (Public Library of Science, 2015-12-23)
    Population fragmentation is threatening biodiversity worldwide. Species that once roamed vast areas are increasingly being conserved in small, isolated areas. Modern management approaches must adapt to ensure the continued ...
  • The selection of a standard STR panel for DNA profiling of the African elephant (Loxodonta africana) in Kenya 
    Kinuthia, Julius; Harper, Cindy Kim; Muya, Shadrack; Kimwele, Charles; Alakonya, Amos; Muigai, Anne; Gakuya, Francis; Mwaniki, Mercy; Gatebe, Erastus (SpringerOpen Journal, 2015-06)
    The African elephant (Loxodonta africana) population in Kenya is declining at an alarming rate due to habitat destruction, human-elephant conflicts and the current escalation of poaching for ivory. This study established a ...
  • The carrier prevalence of severe combined immunodeficiency, lavender foal syndrome and cerebellar abiotrophy in Arabian horses in South Africa 
    Tarr, Carolynne Jane; Thompson, P.N. (Peter N.); Guthrie, Alan John; Harper, Cindy Kim (Wiley, 2014-07)
    REASONS FOR PERFORMING STUDY : The carrier prevalence of severe combined immunodeficiency (SCID), lavender foal syndrome (LFS) and cerebellar abiotrophy (CA) in Arabian foals in South Africawas determined in order to ...
  • Evaluation of microsatellite markers for populations studies and forensic identification of African lions (Panthera leo) 
    Miller, Susan M.; Harper, Cindy Kim; Bloomer, Paulette; Hofmeyr, Jennifer; Funston, Paul J. (Oxford University Press, 2014-11)
    The South African lion (Panthera leo) population is highly fragmented. One third of its wild lions occur in small (<1000 km2) reserves. These lions were reintroduced from other areas of the species’ historical range. ...
  • Cyclic neutropenia in a basset hound 
    Koster, Liza Sally; Harper, Cindy Kim; Goddard, Amelia (BMJ Publishing Group, 2015)
    A 6 month old, male basset hound was referred for intermittent malaise, and pyrexia that repeated every 10-11 days. Sequential blood counts and bone marrow aspirates demonstrated severe neutropaenia and increased myeloid ...
  • Prediction of the optimal time for insemination using frozen-thawed semen in a multi-sire insemination trial in bitches 
    Steckler, Daniela; Nothling, Johan Oliviette; Harper, Cindy Kim (Elsevier, 2013-11)
    The aims of the study were to determine which of Days 5, 6 or 7 after the blood plasma progesterone concentration (PPC) of bitches first reached 6–9 nmol/L (Day 0) yield the highest fertility and whether day of insemination ...
  • The tiger genome and comparative analysis with lion and snow leopard genomes 
    Cho, Yun Sung; Hu, Li; Hou, Haolong; Lee, Hang; Xu, Jiaohui; Kwon, Soowhan; Oh, Sukhun; Kim, Hak-Min; Jho, Sungwoong; Kim, Sangsoo; Shin, Young-Ah; Kim, Byung Chul; Kim, Hyunmin; Kim, Chang-uk; Luo, Shu-Jin; Johnson, Warren E.; Koepfli, Klaus-Peter; Schmidt-Küntzel, Anne; Turner, Jason A.; Marker, Laurie; Harper, Cindy Kim; Miller, Susan M.; Jacobs, Wilhelm; Bertola, Laura D.; Kim, Tae Hyung; Lee, Sunghoon; Zhou, Qian; Jung, Hyun-Ju; Xu, Xiao; Gadhvi, Priyvrat; Xu, Pengwei; Xiong, Yingqi; Luo, Yadan; Pan, Shengkai; Gou, Caiyun; Chu, Xiuhui; Zhang, Jilin; Liu, Sanyang; He, Jing; Chen, Ying; Yang, Linfeng; Yang, Yulan; He, Jiaju; Liu, Sha; Wang, Junyi; Kim, Chul Hong; Kwak, Hwanjong; Kim, Jong-Soo; Hwang, Seungwoo; Ko, Junsu; Kim, Chang-Bae; Kim, Sangtae; Bayarlkhagva, Damdin; Paek, Woon Kee; Kim, Seong-Jin; O’Brien, Stephen J.; Wang, Jun; Bhak, Jong (Nature Publishing Group, 2013-09)
    Tigers and their close relatives (Panthera) are some of the world’s most endangered species. Here we report the de novo assembly of an Amur tiger whole-genome sequence as well as the genomic sequences of a white Bengal ...
  • Comparative genetics of sarcoid tumour-affected and non-affected mountain zebra (Equus zebra) populations 
    Sasidharan, Sooryakanth P.; Ludwig, Anette; Harper, Cindy Kim; Moodley, Yoshan; Bertschinger, Hendrik Jan; Guthrie, Alan John; Somers, Michael J. (Southern African Wildlife Management Association, 2011-04)
    In recent years, South African conservation officials have noted the appearance of sarcoid tumour-like growths in Cape mountain zebra (Equus zebra zebra) populations. In domestic horses (Equus ferus caballus), a genetic ...