Clinical and epidemiological investigations of Orbivirus infections in domestic dogs (Canis lupus familiaris)

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dc.contributor.advisor Fosgate, Geoffrey T.
dc.contributor.coadvisor Guthrie, Alan John
dc.contributor.coadvisor Leisewitz, Andrew L.
dc.contributor.postgraduate Hanekom, Josef Derek
dc.date.accessioned 2024-02-27T10:04:11Z
dc.date.available 2024-02-27T10:04:11Z
dc.date.created 2024-05-03
dc.date.issued 2023-11-12
dc.description Thesis (PhD (Veterinary Science))--University of Pretoria, 2023. en_US
dc.description.abstract Dogs are atypical host species for some of the most economically important orbiviral diseases, African horse sickness (AHS) and bluetongue (BT). Dogs are the only non-equid species to develop the severe fatal form of AHS, and along with the Eurasian lynx, dogs are the only non-ruminants to develop fatal bluetongue (BT). However, the role of dogs as a host species for orbiviruses has been largely dismissed as incidental or of low significance in the epidemiology of orbiviruses. In light of recent dog mortalities due to AHS which occurred with suspected midge-borne transmission, this thesis examines clinical and epidemiological features of Orbivirus diseases in South African dogs. The author shows that exposure to the African horse sickness virus (AHSV) in dogs in Tshwane, South Africa was common and frequent, with as many dogs estimated to have been exposed to AHSV as the population of horses in the area. At the onset of this investigation, only AHS had been described in South African dogs. The author describes the novel identification of the bluetongue virus (BTV) and possible equine encephalosis virus in South African dogs. The author describes the clinical presentation and management of a pregnant dog diagnosed with naturally occurring BT. The author investigates the farm of origin for this dog and shows a high level of exposure to BTV in dogs on the farm was high and detected the viral RNA from blood samples in three dogs (50%). The author reports the detection of equine encephalosis from samples collected from a puppy with a fatal respiratory disease. The findings of this study suggest dogs could play a greater role in the persistence, spread and introduction of orbiviruses than previously thought. en_US
dc.description.availability Unrestricted en_US
dc.description.degree PhD (Veterinary Science) en_US
dc.description.department Companion Animal Clinical Studies en_US
dc.description.faculty Faculty of Veterinary Science en_US
dc.description.sdg SDG-02: Zero Hunger en_US
dc.description.sdg SDG-03: Good health and well-being en_US
dc.description.sdg SDG-15: Life on land en_US
dc.identifier.citation * en_US
dc.identifier.doi https://doi.org/10.25403/UPresearchdata.25133759 en_US
dc.identifier.other A2024 en_US
dc.identifier.uri http://hdl.handle.net/2263/94952
dc.language.iso en en_US
dc.publisher University of Pretoria
dc.rights © 2023 University of Pretoria. All rights reserved. The copyright in this work vests in the University of Pretoria. No part of this work may be reproduced or transmitted in any form or by any means, without the prior written permission of the University of Pretoria.
dc.subject UCTD en_US
dc.subject African horse sickness en_US
dc.subject Bluetongue virus en_US
dc.subject Equine encephalosis virus en_US
dc.subject Seroprevalence en_US
dc.subject Risk factors en_US
dc.subject Clinical presentation and treatment en_US
dc.subject WOAH-listed diseases en_US
dc.subject Importation risk en_US
dc.title Clinical and epidemiological investigations of Orbivirus infections in domestic dogs (Canis lupus familiaris) en_US
dc.type Dissertation en_US


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