Association of prenatal placental function with anthropometry and body composition through 2 years of age in South African infants : the UmbiBaby study

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dc.contributor.author Nel, Sanja
dc.contributor.author Feucht, Ute Dagmar
dc.contributor.author Mulol, Helen
dc.contributor.author Wenhold, Friedeburg Anna Maria
dc.date.accessioned 2023-10-10T07:05:49Z
dc.date.issued 2023-04
dc.description.abstract BACKGROUND : Placental insufficiency negatively impacts fetal growth and body composition (BC), potentially affecting lifelong health. Placental insufficiency, detectable as an abnormal umbilical artery resistance index (UmA-RI) on Doppler ultrasonography, is highly prevalent in otherwise healthy South African pregnant women. Appropriate intervention reduces stillbirth and perinatal death, but research on long-term outcomes of surviving infants is lacking. OBJECTIVES : This study aimed to describe and compare anthropometry and BC during the first 2 y of life in a cohort of term-born infants with normal and abnormal prenatal UmA-RI. METHODS : Term-born infants (n = 81; n = 55 normal, n = 26 abnormal UmA-RI on third trimester Doppler screening) were followed up at 8-time points until age 2 y. Anthropometric measurements were taken, and FFM and FM were assessed by deuterium dilution. Age- and sex-specific z-scores were calculated for anthropometric indices, FM, FFM, FM index (FMI), and FFM index (FFMI) using appropriate reference data. Anthropometry and BC of infants with normal and abnormal UmA-RI were compared using an independent t-test or Mann–Whitney test. RESULTS : At most ages, group mean z-scores were <0 for length-for-age and FM and >0 for weight-for-length and FFM. Compared with infants with normal UmA-RI, infants with abnormal UmA-RI had significantly lower weight-for-age z-scores at birth (−0.77 ± 0.75 compared with −0.30 ± 1.10, P = 0.026), ages 10 wk to 9 mo (−0.4 ± 0.87 to −0.2 ± 1.12 compared with 0.3 ± 0.85 to 0.6 ± 1.09; P = 0.007–0.017) and 18 mo (−0.6 ± 0.82 compared with 0.1 ± 1.18; P = 0.037); length-for-age z-scores at ages ≤14 wk (−1.3 ± 1.25 to −0.9 ± 0.87 compared with −0.2 ± 1.04 to −0.1 ± 1.00; P = 0.004–0.021); and FFM-for-age z-scores at ages ≤9 mo (−0.1 ± 0.82 to 0.7 ± 0.71 compared with 0.7 ± 1.00 to 1.3 ± 0.85; P = 0.002–0.028). FFMI, percentage FFM, FM, percentage FM, and FMI showed no consistent significant differences. CONCLUSIONS : Infants with abnormal UmA-RI had lower weight-for-age and length-for-age z-scores, particularly at younger ages, with proportionally lower FFM but no consistent differences in percentage FFM and FFMI. These findings merit further investigation in larger cohorts. en_US
dc.description.department Human Nutrition en_US
dc.description.department Paediatrics and Child Health en_US
dc.description.embargo 2024-04-13
dc.description.librarian hj2023 en_US
dc.description.sponsorship The South African Medical Research Council. en_US
dc.description.uri http://www.journals.elsevier.com/the-journal-of-nutrition en_US
dc.identifier.citation Nel, S., Feucht, U.D., Mulol, H. & Wenhold, F.A. 2023, 'Association of prenatal placental function with anthropometry and body composition through 2 years of age in South African infants: the UmbiBaby study', Journal of Nutrition, vol. 153, no. 4, pp. 958-969, doi : 10.1016/j.tjnut.2023.02.007. en_US
dc.identifier.issn 0022-3166 (print)
dc.identifier.issn 1541-6100 (online)
dc.identifier.other 10.1016/j.tjnut.2023.02.007
dc.identifier.uri http://hdl.handle.net/2263/92797
dc.language.iso en en_US
dc.publisher Elsevier en_US
dc.rights © 2023 American Society for Nutrition. Published by Elsevier Inc. All rights reserved. Notice : this is the author’s version of a work that was accepted for publication in Journal of Nutrition. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. A definitive version was subsequently published in Journal of Nutrition, vol. 153, no. 4, pp. 958-969, 2023, doi : 10.1016/j.tjnut.2023.02.007. en_US
dc.subject Fetal growth restriction (FGR) en_US
dc.subject Placental insufficiency en_US
dc.subject Doppler ultrasound en_US
dc.subject Body composition en_US
dc.subject Anthropometry en_US
dc.title Association of prenatal placental function with anthropometry and body composition through 2 years of age in South African infants : the UmbiBaby study en_US
dc.type Postprint Article en_US


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