The acidic tumour microenvironment : manipulating the immune response to elicit escape

Worsley, Catherine; Veale, Rob B.; Mayne, Elizabeth S.

dc.contributor.author	Worsley, Catherine
dc.contributor.author	Veale, Rob B.
dc.contributor.author	Mayne, Elizabeth S.
dc.date.accessioned	2023-09-06T13:18:24Z
dc.date.available	2023-09-06T13:18:24Z
dc.date.issued	2022-05
dc.description.abstract	The success of cancer treatment relies on the composition of the tumour microenvironment which is comprised of tumour cells, blood vessels, stromal cells, immune cells, and extracellular matrix components. Barriers to effective cancer treatment need to be overcome, and the acidic microenvironment of the tumour provides a key target for treatment. This review intends to provide an overview of the effects that low extracellular pH has on components of the tumour microenvironment and how they contribute to immune escape. Further, potential therapeutic targets will be discussed.	en_US
dc.description.department	Immunology	en_US
dc.description.librarian	hj2023	en_US
dc.description.sponsorship	The National Research Foundation (NRF) Thuthuka program.	en_US
dc.description.uri	http://www.elsevier.com/locate/humimm	en_US
dc.identifier.citation	Worsley, C.M., Veale, R.B. & Mayne, E.S. 2022, 'The acidic tumour microenvironment: Manipulating the immune response to elicit escape', Human Immunology, vol. 83, no. 5, pp. 399-408, doi : 10.1016/j.humimm.2022.01.014.	en_US
dc.identifier.issn	0198-8859
dc.identifier.other	10.1016/j.humimm.2022.01.014
dc.identifier.uri	http://hdl.handle.net/2263/92233
dc.language.iso	en	en_US
dc.publisher	Elsevier	en_US
dc.rights	© 2022 American Society for Histocompatibility and Immunogenetics. All rights reserved. Notice : this is the author’s version of a work that was accepted for publication in Human Immunology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. A definitive version was subsequently published in Human Immunology, vol. 83, no. 5, pp. 399-408, 2022, doi : 10.1016/j.humimm.2022.01.014.	en_US
dc.subject	Tumour microenvironment (TME)	en_US
dc.subject	Acidosis	en_US
dc.subject	Tolerance	en_US
dc.subject	Immune escape	en_US
dc.subject	T cells	en_US
dc.subject	SDG-03: Good health and well-being	en_US
dc.title	The acidic tumour microenvironment : manipulating the immune response to elicit escape	en_US
dc.type	Postprint Article	en_US