dc.contributor.author |
Mankgele, Mahlatse
|
|
dc.contributor.author |
Variava, Ebrahim
|
|
dc.contributor.author |
Moloantoa, Tumelo
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|
dc.contributor.author |
Otwombe, Kennedy
|
|
dc.contributor.author |
Hlongwane, Khuthadzo
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|
dc.contributor.author |
Disenyane, Dineo
|
|
dc.contributor.author |
Bida, Meshack
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dc.contributor.author |
Chikwati, Raylton
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|
dc.contributor.author |
Snyman, Tracy
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|
dc.contributor.author |
Martinson, Neil
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|
dc.contributor.author |
Mahlangu, Johnny
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|
dc.date.accessioned |
2023-09-04T10:06:24Z |
|
dc.date.available |
2023-09-04T10:06:24Z |
|
dc.date.issued |
2023-08 |
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dc.description |
DATA AVAILABILITY STATEMENT : Data are available upon reasonable request. |
en_US |
dc.description.abstract |
AIM : We compared soluble transferrin receptors (sTfR), serum ferritin, mean cell volume (MCV) of red cells and the sTfR-ferritin index with the intensive method bone marrow trephine (BMT) iron stores in the diagnosis of iron deficiency anaemia (IDA) in Human Immunodeficiency Virus (HIV)-positive hospitalised participants.
METHODS : In this cross-sectional study, we recruited hospitalised HIV-positive and coronavirus of 2019 (COVID-19)-negative adults with anaemia who required a bone marrow examination as part of their diagnostic workup. We measured the full blood count, ferritin, sTfR and assessed iron using the intensive method in Haemotoxylin and Eosin (H&E)-stained BMT core biopsies of consenting participants.
RESULTS : Of the 60 enrolled participants, 57 were evaluable. Thirteen (22.80%) had IDA on H&E BMT iron stores assessment, and 44 (77.19%) had anaemia of chronic diseases (ACD). The sTfR and the sTfR-ferritin index had sensitivities of 61.54% and 53.85%, respectively, for IDA diagnosis. The sensitivity and specificity of ferritin was 7.69% and 92.31%, respectively. The sTfR and sTfR-ferritin index’s diagnostic specificity was relatively low at 46.15% and 38.46%, respectively.
CONCLUSION : In this pilot study in HIV-positive participants, the prevalence of iron deficiency using the BMT assessment was low. Both the sTfR and the sTfR-ferritin index had a better quantitative correlation to bone marrow iron stores when compared with the MCV and ferritin and, may be more accurate surrogate markers of IDA. |
en_US |
dc.description.department |
Anatomical Pathology |
en_US |
dc.description.librarian |
hj2023 |
en_US |
dc.description.uri |
https://jcp.bmj.com |
en_US |
dc.identifier.citation |
Mankgele M, Variava E, Moloantoa T, et al. 2023, 'Underdiagnosis of iron deficiency anaemia in HIV-infected individuals : a pilot study using soluble transferrin receptors and intensive bone marrow iron stores to improve the diagnosis', Journal of Clinical Pathology, vol. 76, no. 8, pp. 555-560, doi : 10.1136/jcp-2022-208172. |
en_US |
dc.identifier.issn |
0021-9746 (print) |
|
dc.identifier.issn |
1472-4146 |
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dc.identifier.other |
10.1136/jcp-2022-208172 |
|
dc.identifier.uri |
http://hdl.handle.net/2263/92155 |
|
dc.language.iso |
en |
en_US |
dc.publisher |
BMJ Publishing Group |
en_US |
dc.rights |
© Author(s) (or their employer(s)) 2023. This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license. |
en_US |
dc.subject |
Soluble transferrin receptors (sTfR) |
en_US |
dc.subject |
Serum ferritin |
en_US |
dc.subject |
Mean cell volume (MCV) |
en_US |
dc.subject |
Red cells |
en_US |
dc.subject |
sTfR-ferritin index |
en_US |
dc.subject |
Bone marrow trephine (BMT) |
en_US |
dc.subject |
Iron deficiency anaemia (IDA) |
en_US |
dc.subject |
Human immunodeficiency virus (HIV) |
en_US |
dc.subject |
Hospitalisation |
en_US |
dc.subject |
HIV-infected patients |
en_US |
dc.subject.other |
Health sciences articles SDG-03 |
|
dc.subject.other |
SDG-03: Good health and well-being |
|
dc.subject.other |
Health sciences articles SDG-17 |
|
dc.subject.other |
SDG-17: Partnerships for the goals |
|
dc.title |
Underdiagnosis of iron deficiency anaemia in HIV-infected individuals : a pilot study using soluble transferrin receptors and intensive bone marrow iron stores to improve the diagnosis |
en_US |
dc.type |
Article |
en_US |