Ketamine-medetomidine compared to tiletamine-zolazepam-medetomidine for immobilisation of semi-captive cheetahs (Acinonyx jubatus)

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dc.contributor.author Buck, Roxanne
dc.contributor.author Tordiffe, A.S.W. (Adrian Stephen Wolferstan)
dc.contributor.author Zeiler, Gareth Edward
dc.date.accessioned 2023-08-24T06:37:58Z
dc.date.available 2023-08-24T06:37:58Z
dc.date.issued 2022
dc.description.abstract The immobilisation time and cardiopulmonary effects of ketamine-medetomidine (KM) and tiletamine-zolazepam-medetomidine (TZM) were compared in semi-captive cheetahs (Acinonyx jubatus). Seven healthy adult cheetahs were included in a randomised prospective crossover study. Each cheetah was immobilised on two occasions by remote injection, once with a combination of ketamine (4.93 ± 0.75 mg/kg) and medetomidine (0.038 ± 0.003 mg/kg) (KM) and once with tiletamine-zolazepam (1.16 ± 0.12 mg/kg) and medetomidine (0.039 ± 0.002 mg/kg) (TZM). Time to safe approach, characterised by absent responses to an ear flick and tail tug, was recorded as the immobilisation time. Following immobilisation, cardiopulmonary parameters were recorded, and an arterial blood gas sample analysed. Data is reported as mean ± SD and compared using a general linear mixed model (p < 0.05). Immobilisation times were no different between combinations, 11.4 ± 5.7 minutes for KM and 13.2 ± 4.6 minutes for TZM (p = 0.528). Systolic blood pressure was 218 ± 22 mmHg for KM and 210 ± 28 mmHg for TZM (p = 0.594). There was moderate hypoxaemia with both combinations with arterial oxygen partial pressure of 58.4 ± 6.6 mmHg for KM and 61.3 ± 4.2 mmHg for TZM (p = 0.368). Haematocrit was higher with KM (40.7 ± 2.5) than TZM (35.8 ± 2.8, p = 0.007). There were differences in electrolytes, with TZM resulting in higher serum potassium (4.3 ± 0.2 mmol/L, p < 0.001) and glucose (11.8 ± 2.9 mmol/L, p = 0.039) than KM. Both combinations provided acceptable immobilisation for field use, although severe hypertension was a consistent finding. Supplementation with oxygen is recommended with both combinations. en_US
dc.description.department Companion Animal Clinical Studies en_US
dc.description.librarian am2023 en_US
dc.description.uri http://www.jsava.co.za en_US
dc.identifier.citation Buck, R.K., Tordiffe, A.S.W., Zeiler, G.E. 2022, 'Ketamine-medetomidine compared to tiletamine-zolazepam-medetomidine for immobilisation of semi-captive cheetahs (Acinonyx jubatus)', Journal of the South African Veterinary Association, vol. 93, no. 1, pp. 1-7. https://DOI.org/10.36303/JSAVA.2022.93.1.489. en_US
dc.identifier.issn 1019-9128 (print)
dc.identifier.issn 2224-9435 (online)
dc.identifier.other 10.36303/JSAVA.2022.93.1.489
dc.identifier.uri http://hdl.handle.net/2263/92025
dc.language.iso en en_US
dc.publisher Medpharm Publications en_US
dc.rights © 2022 The Author(s). Open Access article distributed under the terms of the Creative Commons License [CC BY-NC 3.0]. en_US
dc.subject Acinonyx jubatus en_US
dc.subject Immobilisation en_US
dc.subject Ketamine en_US
dc.subject Medetomidine en_US
dc.subject Cheetah (Acinonyx jubatus) en_US
dc.subject Ketamine-medetomidine (KM) en_US
dc.subject Tiletamine-zolazepam-medetomidine (TZM) en_US
dc.title Ketamine-medetomidine compared to tiletamine-zolazepam-medetomidine for immobilisation of semi-captive cheetahs (Acinonyx jubatus) en_US
dc.type Article en_US


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