Abstract:
BACKGROUND : The association between reporting adverse coronavirus
disease 2019 (COVID-19) vaccination effects and those with a history
of audiovestibular difficulties is unknown. The aim of this research is
therefore to investigate adverse vaccination effects in adults with a
history of Ménière’s disease. Specifically, the incidence of adverse
effects, the factors associated with those reporting adverse effects
and the relationship between the reporting of audiovestibular and
other adverse effects.
METHODS : A mixed-methods exploratory cross-sectional survey study
design was used. Data were collected from 333 members of the
Finnish Ménière Association. The survey was designed to obtain
demographic information that may be associated with having adverse
effects or not, vaccination-specific information and adverse
vaccination effects. Both health and audiovestibular adverse events
were identified. Data analysis included comparing those reporting and
not reporting adverse vaccination effects.
RESULTS : The mean age was 63 years with 81% being female. Of the
327 respondents who had one of the COVID-19 vaccinations
(Comirnatry/ Pfizer, Astra Zeneca, or Moderna), 203 (62%) reported no
adverse effects. The type of or number of vaccinations were not
related to the reporting of adverse effects. The most frequently
reported adverse effects were injection site tenderness (38%), arm
pain (21%), fever (15%) and headaches (15%). Post-vaccination tinnitus
and vertigo (both 7%) were the most frequently reported
audiovestibular-related symptoms, followed by aural fullness (6%) and hearing loss (4%). Those reporting previous pre-vaccination vertigo
were more likely to have post-vaccination vertigo. The presence of
post-vaccination tinnitus, hearing loss, and aural fullness, predicted
the presence of post-vaccination vertigo.
CONCLUSIONS : A small proportion of patients with a history of
Ménière’s disease may experience adverse post-vaccination effects.
Further research is required to explore whether adverse postvaccination
audiovestibular effects are more prevalent in those with a
history of otological disorders compared with the general population.
Description:
DATA AVAILABILITY : UNDERLYING DATA : Figshare: COVID 19 vaccine in Ménière’s disease, https://doi.org/10.6084/m9.figshare.19519801. This project contains the following underlying data: - COVID vaccine in MD for repository.xslx (raw data). EXTENDED DATA : Figshare: COVID 19 vaccine in Ménière’s disease, https://doi.org/10.6084/m9.figshare.19519801. This project contains the following extended data: - Finnish_MD COVID Vaccination Questionnaire - English_MD COVID Vaccination Questionnaire - S 1S1 The STROBE Checklist. Data are available under the terms of the Creative Commons Attribution 4.0 International license (CC-BY 4.0).