High asymptomatic carriage with the Omicron variant in South Africa

Garrett, N.; Tapley, Asa; Andriesen, Jessica; Seocharan, Ishen; Fisher, Leigh H.; Bunts, Lisa; Epsy, Nicole; Wallis, Carole L.; Randhawa, April Kaur; Miner, Maurine D.; Ketter, Nzeera; Yacovone, Margaret; Goga, Ameena Ebrahim; Huang, Yunda; Hural, John; Kotze, Philip; Bekker, Linda‑Gail; Gray, Glenda E.; Corey, Lawrence; Ubuntu Study Team

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High asymptomatic carriage with the Omicron variant in South Africa

Garrett, N.; Tapley, Asa; Andriesen, Jessica; Seocharan, Ishen; Fisher, Leigh H.; Bunts, Lisa; Epsy, Nicole; Wallis, Carole L.; Randhawa, April Kaur; Miner, Maurine D.; Ketter, Nzeera; Yacovone, Margaret; Goga, Ameena Ebrahim; Huang, Yunda; Hural, John; Kotze, Philip; Bekker, Linda‑Gail; Gray, Glenda E.; Corey, Lawrence; Ubuntu Study Team

URI: http://hdl.handle.net/2263/90659

Date: 2022-07

Abstract:

We report a 23% asymptomatic severe acute respiratory syndrome coronavirus 2 (SARS CoV-2) Omicron carriage rate in participants being enrolled into a clinical trial in South Africa, 15-fold higher than in trials before Omicron. We also found lower CD4 + T-cell counts in persons with human immunodeficiency virus (HIV) strongly correlated with increased odds of being SARS-CoV-2 polymerase chain reaction (PCR) positive.

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