Novel 3-trifluoromethyl-1,2,4-oxadiazole analogues of astemizole with multi-stage antiplasmodium activity and in vivo efficacy in a Plasmodium berghei mouse malaria infection model

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dc.contributor.author Mambwe, Dickson
dc.contributor.author Korkor, Constance M.
dc.contributor.author Mabhula, Amanda
dc.contributor.author Ngqumba, Zama
dc.contributor.author Cloete, Cleavon
dc.contributor.author Kumar, Malkeet
dc.contributor.author Barros, Paula Ladeia
dc.contributor.author Leshabane, Meta Kgaogelo
dc.contributor.author Coertzen, Dina
dc.contributor.author Taylor, Dale
dc.contributor.author Gibhard, Liezl
dc.contributor.author Njoroge, Mathew
dc.contributor.author Lawrence, Nina
dc.contributor.author Reader, Janette
dc.contributor.author Moreira, Diogo Rodrigo
dc.contributor.author Birkholtz, Lyn-Marie
dc.contributor.author Wittlin, Sergio
dc.contributor.author Egan, Timothy J.
dc.contributor.author Chibale, Kelly
dc.date.accessioned 2023-02-24T08:08:34Z
dc.date.issued 2022-12
dc.description.abstract Please read abstract in the article. en_US
dc.description.department Biochemistry en_US
dc.description.department Genetics en_US
dc.description.department Microbiology and Plant Pathology en_US
dc.description.department UP Centre for Sustainable Malaria Control (UP CSMC) en_US
dc.description.embargo 2023-12-12
dc.description.librarian hj2023 en_US
dc.description.uri http://pubs.acs.org/loi/jmcmar en_US
dc.identifier.citation Mambwe, D., Korkor, C.M., Mabhula, A. et al. 2022, 'Novel 3-trifluoromethyl-1,2,4-oxadiazole analogues of astemizole with multi-stage antiplasmodium activity and in vivo efficacy in a Plasmodium berghei mouse malaria infection model', Journal of Medicinal Chemistry, vol. 65, no. 24, pp. 16695–16715, doi : 10.1021/acs.jmedchem.2c01516. en_US
dc.identifier.issn 0022-2623 (print)
dc.identifier.issn 1520-4804 (online)
dc.identifier.other 10.1021/acs.jmedchem.2c01516
dc.identifier.uri https://repository.up.ac.za/handle/2263/89809
dc.language.iso en en_US
dc.publisher American Chemical Society en_US
dc.rights This document is the Accepted Manuscript version of a Published Work that appeared in final form in Journal of Medicinal Chemistry, © 2022 American Chemical Society after peer review and technical editing by the publisher. [12 months embargo] en_US
dc.subject Astemizole en_US
dc.subject Repositioning en_US
dc.subject Plasmodium falciparum en_US
dc.subject Plasmodium berghei en_US
dc.subject Human ether-á-go-go-related gene (hERG) en_US
dc.subject Live-cell microscopy en_US
dc.title Novel 3-trifluoromethyl-1,2,4-oxadiazole analogues of astemizole with multi-stage antiplasmodium activity and in vivo efficacy in a Plasmodium berghei mouse malaria infection model en_US
dc.type Postprint Article en_US


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