Rapid formation of 2-lithio-1-(triphenylmethyl)imidazole and substitution reactions in flow

Wang, Simeng; Panayides, Jenny-Lee; Riley, Darren Lyall; Tighe, Christopher J.; Hellgardt, Klaus; Hii, King Kuok (Mimi); Miller, Philip W.

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dc.contributor.author	Wang, Simeng
dc.contributor.author	Panayides, Jenny-Lee
dc.contributor.author	Riley, Darren Lyall
dc.contributor.author	Tighe, Christopher J.
dc.contributor.author	Hellgardt, Klaus
dc.contributor.author	Hii, King Kuok (Mimi)
dc.contributor.author	Miller, Philip W.
dc.date.accessioned	2022-12-01T11:57:28Z
dc.date.available	2022-12-01T11:57:28Z
dc.date.issued	2021-09
dc.description.abstract	The functionalisation of imidazoles is a necessary step in the formation of many active pharmaceutical intermediates. Herein, we report a flow chemistry approach for the rapid and efficient formation of 2-lithio-1-(triphenylmethyl)imidazole at ambient temperature and its reaction with a range of electrophiles, achieving modest to high yields (40–94%) in short reaction times (<1 min). The method is amenable to the scale-up of this highly reactive lithio-imidazole intermediate.	en_US
dc.description.department	Chemistry	en_US
dc.description.librarian	hj2022	en_US
dc.description.sponsorship	An Imperial College London Research England GCRF Institutional Award.	en_US
dc.description.uri	https://pubs.rsc.org/en/journals/journalissues/re	en_US
dc.identifier.citation	Wang, S., Panayides, J.-L., Riley, D. et al. 2021, 'Rapid formation of 2-lithio-1-(triphenylmethyl)imidazole and substitution reactions in flow', Reaction Chemistry and Engineering, vol. 6, no. 11, pp. 2018-2023, https://doi.org/10.1039/D1RE00343G.	en_US
dc.identifier.issn	2058-9883 (online)
dc.identifier.other	10.1039/D1RE00343G
dc.identifier.uri	https://repository.up.ac.za/handle/2263/88586
dc.language.iso	en	en_US
dc.publisher	Royal Society of Chemistry	en_US
dc.rights	© The Royal Society of Chemistry 2021	en_US
dc.subject	Rapid formation	en_US
dc.subject	Efficient formation	en_US
dc.subject	2-lithio-1-(triphenylmethyl)imidazole	en_US
dc.subject	Substitution reactions	en_US
dc.subject	Flow	en_US
dc.title	Rapid formation of 2-lithio-1-(triphenylmethyl)imidazole and substitution reactions in flow	en_US
dc.type	Postprint Article	en_US