Empowering differential networks using Bayesian analysis

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dc.contributor.author Smith, Jarod
dc.contributor.author Arashi, Mohammad
dc.contributor.author Bekker, Andriette, 1958-
dc.date.accessioned 2022-11-04T06:12:22Z
dc.date.available 2022-11-04T06:12:22Z
dc.date.issued 2022-01-25
dc.description DATA AVAILABILITY STATEMENT : The data underlying the results presented in the study are available from https://archive.ics.uci.edu/ml/datasets/ spambase for the spambase dataset. The corresponding COVID-19 data are available from https://www.nicd.ac.za/diseases-a-z-index/diseaseindex-covid-19/surveillance-reports/ and https:// ourworldindata.org/coronavirus/country/southafrica. en_US
dc.description SUPPORTING INFORMATION : S1 File. Supplementary material. Contains a block Gibbs sampler, as well as, additional optimal threshold; adjacency heatmaps and graphical network figures for dimensions p = 30 and p = 100. https://doi.org/10.1371/journal.pone.0261193.s001 en_US
dc.description.abstract Differential networks (DN) are important tools for modeling the changes in conditional dependencies between multiple samples. A Bayesian approach for estimating DNs, from the classical viewpoint, is introduced with a computationally efficient threshold selection for graphical model determination. The algorithm separately estimates the precision matrices of the DN using the Bayesian adaptive graphical lasso procedure. Synthetic experiments illustrate that the Bayesian DN performs exceptionally well in numerical accuracy and graphical structure determination in comparison to state of the art methods. The proposed method is applied to South African COVID-19 data to investigate the change in DN structure between various phases of the pandemic. en_US
dc.description.department Statistics en_US
dc.description.librarian dm2022 en_US
dc.description.sponsorship The National Research Foundation (NRF) of South Africa. en_US
dc.description.uri http://www.plosone.org en_US
dc.identifier.citation Smith, J., Arashi, M. & Bekker, A. (2022) Empowering differential networks using Bayesian analysis. PLoS One 17(1): e0261193. https://doi.org/10.1371/journal.pone.0261193. en_US
dc.identifier.issn 1932-6203 (online)
dc.identifier.other 10.1371/journal.pone.0261193
dc.identifier.uri https://repository.up.ac.za/handle/2263/88138
dc.language.iso en en_US
dc.publisher Public Library of Science en_US
dc.rights © 2022 Smith et al. This is an open access article distributed under the terms of the Creative Commons Attribution License. en_US
dc.subject Differential networks en_US
dc.subject Bayesian analysis en_US
dc.title Empowering differential networks using Bayesian analysis en_US
dc.type Article en_US


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