• Inconsistencies within the proposed framework for stabilizing fungal nomenclature risk further confusion 

  Kidd, Sarah E.; Hagen, Ferry; Halliday, Catriona L.; Abdolrasouli, Alireza; Boekhout, Teun; Crous, Pedro W.; Ellis, David H.; Elvy, Juliet; Forrest, Graeme N.; Groenewald, Marizeth; Hahn, Rosane C.; Houbraken, Jos; Rodrigues, Anderson M.; Scott, James; Sorrell, Tania C.; Summerbell, Richard C.; Tsui, Clement K.M.; Yurkov, Andrey M.; Chen, Sharon C.-A. (American Society for Microbiology, 2024-04)

  We read with interest the recent publication by de Hoog and colleagues in the Journal of Clinical Microbiology (1) and support the goal to stabilize fungal nomenclature. Although we recognize the importance of stable naming, ...
• FEP augmentation as a means to solve data paucity problems for machine learning in chemical biology 

  Burger, Pieter B.; Hu, Xiaohu; Balabin, Ilya; Muller, Morne; Stanley, Megan; Joubert, Fourie; Kaiser, Thomas M. (American Chemical Society, 2024-04-23)

  In the realm of medicinal chemistry, the primary objective is to swiftly optimize a multitude of chemical properties of a set of compounds to yield a clinical candidate poised for clinical trials. In recent years, two ...
• Plasmid DNA-based reverse genetics as a platform for manufacturing of bluetongue vaccine 

  Mlingo, Tendai A.M.; Theron, Jacques; Mokoena, Nobalanda B. (American Society for Microbiology, 2025)

  Control of bluetongue disease is predominantly through vaccination with licensed inactivated or live-attenuated vaccines (LAVs). Manufacturing of LAVs in endemic countries requires formulation with a high number of serotypes ...
• Ecological success of extreme halophiles subjected to recurrent osmotic disturbances is primarily driven by congeneric species replacement 

  Bustos-Caparros, Esteban; Viver, Tomeu; Gago, Juan F.; Rodriguez-R, Luis M.; Hatt, Janet K.; Venter, S.N. (Stephanus Nicolaas); Fuchs, Bernhard M.; Amann, Rudolf; Bosch, Rafael; Konstantinidis, Konstantinos T.; Rossello-Mora, Ramon (Oxford University Press, 2024-11)

  To understand how extreme halophiles respond to recurrent disturbances, we challenged the communities thriving in salt-saturated (∼36% salts) ∼230 L brine mesocosms to repeated dilutions down to 13% (D13 mesocosm) or 20% ...
• Managing wilding pines in the Cape Floristic Region, South Africa : progress and prospects 

  Martin, Grant D.; Canavan, Kim; Chikowore, Gerald; Bugan, Richard; De Lange, Willem; Du Toit, Ben; Harding, Graham; Heath, Ronald; Hill, Martin; Hurley, Brett Phillip; Ivey, Philip; Muir, Debbie; Musedeli, Jufter; Richardson, David M.; Slippers, Bernard; Stafford, Louise; Turner, Andrew; Watson, Kirsten; Van Wilgen, Brian W. (Elsevier, 2025-02)

  The occurrence and continuing spread of wilding pines (genus Pinus) in the Cape Floristic Region (CFR), South Africa, impacts negatively on water resources, threatens the region's rich biodiversity, and increases the damage ...
• Characterization of the soil resistome and mobilome in Namib Desert soils 

  Naidoo, Yashini; Pierneef, Rian E.; Cowan, Don A.; Valverde, Angel (Springer, 2024-08)

  The study of the soil resistome is important in understanding the evolution of antibiotic resistance and its dissemination between the clinic and the environment. However, very little is known about the soil resistome, ...
• An integrative re-evaluation of the Fusarium sambucinum species complex 

  Sandoval-Denis, M.; Costa, M.M.; Broders, K.; Becker, Y.; Maier, W.; Yurkov, A.; Kermode, A.; Buddie, A.G.; Ryan, M.J.; Schumacher, R.K.; Groenewald, J.Z.; Crous, Pedro W. (Westerdijk Fungal Biodiversity Institute, 2025-03)

  The species-rich Fusarium sambucinum species complex (FSAMSC; Fusarium, Nectriaceae, Hypocreales) is well-known for including devastating plant pathogens and toxigenic species. However, this group of grass-loving fungi ...
• Central nervous system infection by free-living nematode Cephalobus cubaensis in a human host in Africa 

  Sriruttan-Nel, Charlotte; Cairns, Chelline; Boughan, Shareen; Moodley, Bhavani; Sun, Lisa Ming; Chan, Wai Yin; Ismail, Arshad; Mwazha, Absalom; Bennimahadeo, Praniel; Manickchund, Nithendra; Moyo, Mthabisi; Nkwanyana, Thabani; Msimang, Mpumelelo Z.; Essa, Ahmed; Frean, John; Moosa, Mahomed-Yunus (MDPI, 2025-02)

  BACKGROUND : Human central nervous system infections due to free-living nematodes, although extremely rare, are usually fatal. Immunodeficiency has not been a feature of most of these cases, unlike the situation pertaining ...
• Prevalence of aeroallergen sensitization in a polluted and industrialized area : a pilot study in South Africa's Vaal Triangle 

  Gharbi, Dorra; Neumann, Frank Harald; Staats, Jurgens; Mcdonald, Marinda; Linde, Jo-hanné; Mmatladi, Tshiamo; Podile, Keneilwe; Piketh, Stuart; Burger, Roelof; Garland, Rebecca M.; Bester, Petra; Lebre, Pedro H.; Ricci, Cristian (Springer, 2025-02)

  This pioneering study evaluates the prevalence of aeroallergens reactivity among atopic populations living in the Vaal Triangle Airshed Priority Area (VTAPA), South Africa. A total of 138 volunteers (51 males and 87 females), ...
• The functional and structural succession of mesic-grassland soil microbiomes beneath decomposing large herbivore carcasses 

  Fouche, Jacques; Lebre, Pedro H.; Melville, Haemish A.; Cowan, Don A. (Wiley, 2025-01)

  Plant detritus is abundant in grasslands but decomposes slowly and is relatively nutrient-poor, whereas animal carcasses are labile and nutrient-rich. Recent studies have demonstrated that labile nutrients from carcasses ...
• A highly divergent mitochondrial genome in extant Cape buffalo from Addo Elephant National Park, South Africa 

  De Jager, Deon; Moller, Marlo; Hoal, Eileen; Van Helden, Paul David; Glanzmann, Brigitte; Harper, Cindy Kim; Bloomer, Paulette (Wiley, 2025-01)

  The reduced cost of next-generation sequencing (NGS) has allowed researchers to generate nuclear and mitochondrial genome data to gain deeper insights into the phylogeography, evolutionary history and biology of non-model ...
• Fungal biocontrol agents in the management of postharvest losses of fresh produce-a comprehensive review 

  Ramudingana, Phathutshedzo; Makhado, Ndivhuho; Kamutando, Casper Nyaradzai; Thantsha, Mapitsi Silvester; Mamphogoro, Tshifhiwa Paris (MDPI, 2025-01)

  Postharvest decay of vegetables and fruits presents a significant threat confronting sustainable food production worldwide, and in the recent times, applying synthetic fungicides has become the most popular technique of ...
• Helichrysum populifolium compounds inhibit MtrCDE efflux pump transport protein for the potential management of gonorrhoea infection 

  Mulaudzi, Vhangani E.; Adeosun, Idowu J.; Adewumi, Adeniyi T.; Soliman, Mahmoud E.S.; Cosa, Sekelwa (MDPI, 2024-12-11)

  The progressive development of resistance in Neisseria gonorrhoeae to almost all available antibiotics has made it crucial to develop novel approaches to tackling multi-drug resistance (MDR). One of the primary causes ...
• A possible genetic predisposition to suspected hypoxic-ischaemic encephalopathy 

  Holborn, Megan A.; Mellet, Juanita; Joubert, Fourie; Ballot, D.; Pepper, Michael Sean (Elsevier, 2025-04)

  Within the last decade, several studies have explored whether there might be a genetic component in hypoxic-ischaemic encephalopathy (HIE) that influences susceptibility to or outcomes following hypoxic-ischaemic injury. ...
• Carboxy-amidated AamAP1-lys has superior conformational flexibility and accelerated killing of gram-negative bacteria 

  Van Wyk, Rosalind Jeanette; Serem, June Cheptoo; Oosthuizen, Carel B.; Semenya, Dorothy; Serian, Miruna; Lorenz, Christian D.; Mason, A. James; Bester, Megan Jean; Gaspar, Anabella Regina Marques (American Chemical Society, 2025-02)

  Please read abstract in the article.
• doubletrouble : an R/Bioconductor package for the identification, classification, and analysis of gene and genome duplications 

  Almeida-Silva, Fabricio; Van de Peer, Yves (Oxford University Press, 2025-02)

  Gene and genome duplications are major evolutionary forces that shape the diversity and complexity of life. However, different duplication modes have distinct impacts on gene function, expression, and regulation. Existing ...
• Comparative analysis of phytonutrients of Moringa oleifera leaves from South Africa and Nigeria, and their antimicrobial and antioxidant potentials by UPLC-ESI-QToF-MS and OPLS-DA chemometric analysis 

  Kayembe, Jonathan; Sekelwa, Cosa; Bassey, Kokoette (Frontiers Media, 2025-01-27)

  BACKGROUND : Moringa oleifera Lam. has bioactive phytonutrients in abundance and offers diverse health benefits. The leaves of this plant have established significance in traditional medicine and nutrition. It is ...
• Improving the activity and selectivity of a scorpion-derived peptide, A3a, against Acinetobacter baumannii through rational design 

  Moller, Dalton Sharl; Van der Walt, Mandelie; Oosthuizen, Carel; Serian, Miruna; Serem, June Cheptoo; Lorenz, Christian D.; Mason, A. James; Bester, Megan Jean; Gaspar, Anabella Regina Marques (American Chemical Society, 2025-01)

  The rise in antimicrobial resistance has led to an increased desire to understand how antimicrobial peptides (AMPs) can be better engineered to kill antibiotic-resistant bacteria. Previously, we showed that C-terminal ...
• Synthesis and SAR studies of acyl-thiourea platinum(II) complexes yield analogs with dual-stage antiplasmodium activity 

  Ishmail, Fatima-Zahra; Coertzen, Dina; Tshabalala, Sizwe; Leshabane, Meta Kgaogelo; Da Rocha, Shanté; Njoroge, Mathew; Gibhard, Liezl; Birkholtz, Lyn-Marie; Woodland, John G.; Egan, Timothy J.; Wicht, Kathryn J.; Chibale, Kelly (American Chemical Society, 2025-03)

  Mixed-ligand platinum(II) complexes incorporating bipyridine and acyl-thiourea ligands were synthesized and evaluated for their in vitro growth inhibitory activity against the human malaria parasite Plasmodium falciparum ...
• Interventions for the control of Crimean-Congo hemorrhagic fever and tick vectors 

  De la Fuente, Jose; Ghosh, Srikant; Lempereur, Laetitia; Garrison, Aura; Sprong, Hein; Lopez-Camacho, Cesar; Maritz‑Olivier, Christine; Contreras, Marinela; Moraga-Fernández, Alberto; Bente, Dennis A. (Nature Research, 2024-10)

  Crimean-Congo hemorrhagic fever (CCHF) is a zoonotic disease associated with its principal tick vector, Hyalomma spp. with increasing fatal incidence worldwide. Accordingly, CCHF is a World Health Organization-prioritized ...

View more