Abstract:
Cannabis access laws allow for the use of cannabis in private and the trade, purchase and use of hemp-related products as a complementary
medicine and for other benefits. Cannabidiol (CBD) has the treatment potential for several conditions but, with the lack of resources in
South Africa to maintain the legislation, products contaminated with delta-9-tetrahydrocannabinol (Δ9
-THC) are sold by some suppliers
who do not comply with the legislative provisions in terms of the threshold concentrations for Δ9
-THC. This dilemma complicates a medical
review officer’s decision regarding intentional use of Δ9
-THC or otherwise, since a CBD user may have purchased the product legally and in
good faith. Hemp- and CBD-containing products were analysed by gas chromatography-mass spectrometry and compliance was assessed
for CBD and Δ9
-THC purity against the legislative thresholds. A strategy based on metabolite ratios is suggested to distinguish between
intentional or irresponsible cannabis use and legitimate CBD use
