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| dc.contributor.author | Birkholtz, Lyn-Marie
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| dc.contributor.author | Alano, Pietro
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| dc.contributor.author | Leroy, Didier
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| dc.date.accessioned | 2022-09-05T09:27:06Z | |
| dc.date.available | 2022-09-05T09:27:06Z | |
| dc.date.issued | 2022-05 | |
| dc.description.abstract | Preventing human-to-mosquito transmission of malaria parasites provides possible solutions to interrupt the malaria parasite life cycle for malaria elimination. The development of validated routine assays enabled the discovery of such transmission-blocking compounds. Currently, one development priority remains on combinations of dual-active compounds with equipotent activity against both the disease-causing asexual and transmissible, sexual erythrocytic stages. Additionally, transmission-blocking compounds that target gametocyte-specific biology could be used in combination with compounds against asexual parasites. In either case, preventing transmission will reduce the risk of reinfection and, if different processes are targeted, also curb the spread of drug resistance. Here, we provide an updated roadmap to the discovery and development of new antimalarials with transmission-blocking activity to guide drug discovery for malaria elimination. | en_US |
| dc.description.department | Biochemistry | en_US |
| dc.description.department | Genetics | en_US |
| dc.description.department | Microbiology and Plant Pathology | en_US |
| dc.description.department | UP Centre for Sustainable Malaria Control (UP CSMC) | en_US |
| dc.description.librarian | hj2022 | en_US |
| dc.description.sponsorship | The South African Department of Science and Innovation (DSI); the National Research Foundation (SA NRF) South African Research Chair Initiative; drug discovery funding from the Italy/South Africa Joint Research Program (ISARP) from the SA DSI and NRF and the Italian Ministries of Health and of Foreign Affairs and International Cooperation. | en_US |
| dc.description.uri | http://www.journals.elsevier.com/trends-in-parasitology | en_US |
| dc.identifier.citation | Birkholtz, L.-M., Alano, P. & Leroy, D. 2022, 'Transmission-blocking drugs for malaria elimination', Trends in Parasitology, vol. 38, no. 5, pp. 390-403, doi : 10.1016/j.pt.2022.01.011. | en_US |
| dc.identifier.issn | 1471-4922 (print) | |
| dc.identifier.issn | 1471-5007 (online) | |
| dc.identifier.other | 10.1016/j.pt.2022.01.011 | |
| dc.identifier.uri | https://repository.up.ac.za/handle/2263/87069 | |
| dc.language.iso | en | en_US |
| dc.publisher | Elsevier | en_US |
| dc.rights | © 2022 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). | en_US |
| dc.subject | Malaria | en_US |
| dc.subject | Plasmodium falciparum gametocytes | en_US |
| dc.subject | Transmission | en_US |
| dc.subject | Drug discovery | en_US |
| dc.subject | Malaria elimination | en_US |
| dc.subject | Malaria eradication | en_US |
| dc.title | Transmission-blocking drugs for malaria elimination | en_US |
| dc.type | Article | en_US |
