A comparison of labelling characteristics of manual and automated synthesis methods for gallium-68 labelled ubiquicidin
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| dc.contributor.author | Le Roux, Jannie
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| dc.contributor.author | Rubow, Sietske
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| dc.contributor.author | Ebenhan, Thomas
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| dc.date.accessioned | 2022-06-28T12:29:34Z | |
| dc.date.issued | 2021-02 | |
| dc.description.abstract | Gallium-68 labelled 1,4,7-triazacyclononane-1,4,7-triacetic acid ubiquicidin (NOTA-UBI) is currently investigated as a PET radiopharmaceutical for the imaging of infections. The aim of this study was to compare the labelling characteristics of an optimized manual radiosynthesis method with those of optimized automated synthesis methods. Data from this study suggest that automated radiosynthesis of [68Ga]Ga-NOTA-UBI provides a higher degree of robustness and repeatability than the manual method. Our results also suggest that for our full-scale automated synthesis, radical scavengers should be considered to reduce radiolysis. Automated synthesis methods have the advantage of markedly reducing radiation exposure to operators. Standardised automation also makes the synthesis more reliably compliant with Good Manufacturing Practice guidelines. | en_US |
| dc.description.department | Nuclear Medicine | en_US |
| dc.description.embargo | 2023-01-05 | |
| dc.description.librarian | hj2022 | en_US |
| dc.description.sponsorship | The Nuclear Technologies in Medicine and Biosciences Initiative (NTeMBI). | en_US |
| dc.description.uri | http://www.elsevier.com/locate/apradiso | en_US |
| dc.identifier.citation | Van der Merwe, A.J., Van Rensburg, N.F.J. & Sieberhagen, R.H. 2021, 'A comparison of labelling characteristics of manual and automated synthesis methods for gallium-68 labelled ubiquicidin', Applied Radiation and Isotopes, vol. 168, art. 109452, pp. 1-6, doi : 10.1016/j.apradiso.2020.109452. | en_US |
| dc.identifier.issn | 0969-8043 (print) | |
| dc.identifier.issn | 1872-9800 (online) | |
| dc.identifier.other | 10.1016/j.apradiso.2020.109452 | |
| dc.identifier.uri | https://repository.up.ac.za/handle/2263/85987 | |
| dc.language.iso | en | en_US |
| dc.publisher | Elsevier | en_US |
| dc.rights | © 2021 Elsevier Ltd. All rights reserved. Notice : this is the author’s version of a work that was accepted for publication in Applied Radiation and Isotopes. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. A definitive version was subsequently published in Applied Radiation and Isotopes, vol. 168, art. 109452, pp. 1-6, 2021. doi : 10.1016/j.apradiso.2020.109452. | en_US |
| dc.subject | Ga-68 | en_US |
| dc.subject | Automated synthesis | en_US |
| dc.subject | Manual synthesis | en_US |
| dc.subject | NOTA-UBI | en_US |
| dc.subject | Tin-dioxide generator | en_US |
| dc.subject | Radiation exposure | en_US |
| dc.title | A comparison of labelling characteristics of manual and automated synthesis methods for gallium-68 labelled ubiquicidin | en_US |
| dc.type | Postprint Article | en_US |
