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dc.contributor.author | Boswell, Michael T.![]() |
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dc.contributor.author | Yindom, Louis-Marie![]() |
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dc.contributor.author | Hameiri-Bowen, Dan![]() |
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dc.contributor.author | McHugh, Grace![]() |
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dc.contributor.author | Dauya, Ethel![]() |
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dc.contributor.author | Bandason, Tsitsi![]() |
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dc.contributor.author | Mujuru, Hilda![]() |
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dc.contributor.author | Esbjörnsson, Joakim![]() |
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dc.contributor.author | Ferrand, Rashida A.![]() |
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dc.contributor.author | Rowland-Jones, Sarah![]() |
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dc.date.accessioned | 2022-06-23T09:44:48Z | |
dc.date.issued | 2021-12 | |
dc.description.abstract | OBJECTIVE : Untreated perinatal HIV-1 infection is often associated with rapid disease progression in children with HIV (CWH), characterized by high viral loads and early mortality. TRIM22 is a host restriction factor, which directly inhibits HIV-1 transcription, and its genotype variation is associated with disease progression in adults. We tested the hypothesis that TRIM22 genotype is associated with disease progression in CWH. DESIGN : ART-naive CWH, aged 6–16 years, were recruited from primary care clinics in Harare, Zimbabwe. We performed a candidate gene association study of TRIM22 genotype and haplotypes with markers of disease progression and indicators of advanced disease. METHODS : TRIM22 exons three and four were sequenced by Sanger sequencing and single nucleotide polymorphisms were associated with markers of disease progression (CD4+ T-cell count and HIV viral load) and clinical indicators of advanced HIV disease (presence of stunting and chronic diarrhoea). Associations were tested using multivariate linear and logistic regression models. RESULTS : A total of 241 children, median age 11.4 years, 50% female, were included. Stunting was present in 16% of participants. Five SNPs were analyzed including rs7935564, rs2291842, rs78484876, rs1063303 and rs61735273. The median CD4+ count was 342 (IQR: 195–533) cells/μl and median HIV-1 viral load 34 199 (IQR: 8211–90 662) IU/ml. TRIM22 genotype and haplotypes were not associated with CD4+ T-cell count, HIV-1 viral load, stunting or chronic diarrhoea. CONCLUSION : TRIM22 genotype was not associated with markers of HIV disease progression markers or advanced disease in CWH. | en_US |
dc.description.department | Internal Medicine | en_US |
dc.description.embargo | 2022-12-01 | |
dc.description.librarian | hj2022 | en_US |
dc.description.sponsorship | The Commonwealth Scholarship Commission. The ZENITH trial was supported by the Wellcome Trust. | en_US |
dc.description.uri | http://journals.lww.com/aidsonline | en_US |
dc.identifier.citation | Boswell, M.T., Yindom, L.M., Hameiri-Bowen, D., McHugh, G., Dauya, E., Bandason, T., Mujuru, H., Esbjornsson, J., Ferrand, R.A. & Rowland-Jones, S. TRIM22 genotype is not associated with markers of disease progression in children with HIV-1 infection, AIDS, vol. 35, no. 15, 2021, pp. 2445-2450, doi: 10.1097/QAD.0000000000003053. | en_US |
dc.identifier.issn | 0269-9370 (print) | |
dc.identifier.issn | 1473-5571 (online) | |
dc.identifier.issn | 10.1097/QAD.0000000000003053 | |
dc.identifier.uri | https://repository.up.ac.za/handle/2263/85923 | |
dc.language.iso | en | en_US |
dc.publisher | Lippincott Williams and Wilkins | en_US |
dc.rights | © 2021 Wolters Kluwer Health, Inc. All rights reserved. This is a non-final version of an article published in final form in AIDS, vol. 35, no. 15, 2021, pp. 2445-2450, doi: 10.1097/QAD.0000000000003053. | en_US |
dc.subject | Children | en_US |
dc.subject | Disease progression | en_US |
dc.subject | HIV-1 | en_US |
dc.subject | Perinatal infection | en_US |
dc.subject | Stunting | en_US |
dc.subject | TRIM22 | en_US |
dc.subject | Children with HIV (CWH) | en_US |
dc.title | TRIM22 genotype is not associated with markers of disease progression in children with HIV-1 infection | en_US |
dc.type | Postprint Article | en_US |