dc.contributor.author |
Feucht, Ute Dagmar
|
|
dc.contributor.author |
Mulol, Helen
|
|
dc.contributor.author |
Vannevel, Valerie
|
|
dc.contributor.author |
Pattinson, Robert Clive
|
|
dc.date.accessioned |
2022-05-17T08:35:13Z |
|
dc.date.available |
2022-05-17T08:35:13Z |
|
dc.date.issued |
2021-08 |
|
dc.description.abstract |
BACKGROUND: Fetal growth restriction (FGR), defined as a fetus failing to reach its genetic growth potential,
remains poorly diagnosed antenatally. This study aimed to assess the ability of continuouswave Doppler ultrasound of the umbilical artery (CWD-UmA) to detect FGR in healthy
women with low-risk pregnancies.
METHODS AND FINDINGS: This prospective longitudinal descriptive cohort study enrolled infants born to low-risk mothers who were screened with CWD-UmA between 28–34 weeks’ gestation; the resistance
index (RI) was classified as normal or abnormal. Infants were assessed at 6, 10, 14 weeks,
and 6 months postnatally for anthropometric indicators and body composition using the deuterium dilution method to assess fat-free mass (FFM). Neonates in the abnormal RI group
were compared with those in the normal RI group, and neonates classified as small-for-gestational age (SGA) were compared with appropriate-for-gestational age (AGA) neonates.
Eighty-one term infants were included. Only 6 of 26 infants (23.1%) with an abnormal RI
value would have been classified as SGA. The abnormal RI group had significantly reduced
mean FFM and FFM-for-age Z-scores at 6, 10, 14 weeks, and 6 months compared with the
normal RI group (P<0.015). The SGA group’s FFM did not show this consistent trend when
compared to AGA FFM, being significantly different only at 6 months (P = 0.039).
The main limitation of the study was the small sample size of the infant follow-up.
CONCLUSIONS: Abnormal RI obtained from CWD-UmA is able to detect FGR and is considered a useful
addition to classifying the neonate only by SGA or AGA at birth. |
en_US |
dc.description.department |
Obstetrics and Gynaecology |
en_US |
dc.description.department |
Paediatrics and Child Health |
en_US |
dc.description.librarian |
pm2022 |
en_US |
dc.description.sponsorship |
UNDP/UNFPA/
UNICEF/WHO/World Bank Special Programme of
Research, Development and Research Training in
Human Reproduction (HRP), a cosponsored
program executed by the World Health
Organization |
en_US |
dc.description.uri |
http://www.plosone.org |
en_US |
dc.identifier.citation |
Feucht U, Mulol H, Vannevel V, Pattinson
R (2021) The ability of continuous-wave Doppler
ultrasound to detect fetal growth restriction. PLoS
ONE 16(8): e0255960. https://doi.org/10.1371/journal.pone.0255960. |
en_US |
dc.identifier.issn |
1932-6203 (online) |
|
dc.identifier.other |
10.1371/ journal.pone.0255960 |
|
dc.identifier.uri |
https://repository.up.ac.za/handle/2263/85244 |
|
dc.language.iso |
en |
en_US |
dc.publisher |
Public Library of Science |
en_US |
dc.rights |
© 2021 Feucht et al. This is an open
access article distributed under the terms of the
Creative Commons Attribution License. |
en_US |
dc.subject |
Fetal growth restriction (FGR) |
en_US |
dc.subject |
Antenatal screening |
en_US |
dc.subject |
Wave Doppler ultrasound |
en_US |
dc.subject |
Umbilical artery |
en_US |
dc.subject |
Continuouswave Doppler ultrasound of the umbilical artery (CWD-UmA) |
en_US |
dc.title |
The ability of continuous-wave Doppler ultrasound to detect fetal growth restriction |
en_US |
dc.type |
Article |
en_US |