The ability of continuous-wave Doppler ultrasound to detect fetal growth restriction

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dc.contributor.author Feucht, Ute Dagmar
dc.contributor.author Mulol, Helen
dc.contributor.author Vannevel, Valerie
dc.contributor.author Pattinson, Robert Clive
dc.date.accessioned 2022-05-17T08:35:13Z
dc.date.available 2022-05-17T08:35:13Z
dc.date.issued 2021-08
dc.description.abstract BACKGROUND: Fetal growth restriction (FGR), defined as a fetus failing to reach its genetic growth potential, remains poorly diagnosed antenatally. This study aimed to assess the ability of continuouswave Doppler ultrasound of the umbilical artery (CWD-UmA) to detect FGR in healthy women with low-risk pregnancies. METHODS AND FINDINGS: This prospective longitudinal descriptive cohort study enrolled infants born to low-risk mothers who were screened with CWD-UmA between 28–34 weeks’ gestation; the resistance index (RI) was classified as normal or abnormal. Infants were assessed at 6, 10, 14 weeks, and 6 months postnatally for anthropometric indicators and body composition using the deuterium dilution method to assess fat-free mass (FFM). Neonates in the abnormal RI group were compared with those in the normal RI group, and neonates classified as small-for-gestational age (SGA) were compared with appropriate-for-gestational age (AGA) neonates. Eighty-one term infants were included. Only 6 of 26 infants (23.1%) with an abnormal RI value would have been classified as SGA. The abnormal RI group had significantly reduced mean FFM and FFM-for-age Z-scores at 6, 10, 14 weeks, and 6 months compared with the normal RI group (P<0.015). The SGA group’s FFM did not show this consistent trend when compared to AGA FFM, being significantly different only at 6 months (P = 0.039). The main limitation of the study was the small sample size of the infant follow-up. CONCLUSIONS: Abnormal RI obtained from CWD-UmA is able to detect FGR and is considered a useful addition to classifying the neonate only by SGA or AGA at birth. en_US
dc.description.department Obstetrics and Gynaecology en_US
dc.description.department Paediatrics and Child Health en_US
dc.description.librarian pm2022 en_US
dc.description.sponsorship UNDP/UNFPA/ UNICEF/WHO/World Bank Special Programme of Research, Development and Research Training in Human Reproduction (HRP), a cosponsored program executed by the World Health Organization en_US
dc.description.uri http://www.plosone.org en_US
dc.identifier.citation Feucht U, Mulol H, Vannevel V, Pattinson R (2021) The ability of continuous-wave Doppler ultrasound to detect fetal growth restriction. PLoS ONE 16(8): e0255960. https://doi.org/10.1371/journal.pone.0255960. en_US
dc.identifier.issn 1932-6203 (online)
dc.identifier.other 10.1371/ journal.pone.0255960
dc.identifier.uri https://repository.up.ac.za/handle/2263/85244
dc.language.iso en en_US
dc.publisher Public Library of Science en_US
dc.rights © 2021 Feucht et al. This is an open access article distributed under the terms of the Creative Commons Attribution License. en_US
dc.subject Fetal growth restriction (FGR) en_US
dc.subject Antenatal screening en_US
dc.subject Wave Doppler ultrasound en_US
dc.subject Umbilical artery en_US
dc.subject Continuouswave Doppler ultrasound of the umbilical artery (CWD-UmA) en_US
dc.title The ability of continuous-wave Doppler ultrasound to detect fetal growth restriction en_US
dc.type Article en_US


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