• Peri-operative pharmacokinetics of cefazolin prophylaxis during valve replacement surgery 

  Alli, Ahmad; Paruk, Fathima; Roger, Claire; Lipman, Jeffrey; Calleemalay, Daren; Wallis, Steven C.; Scribante, Juan; Richards, Guy A.; Roberts, Jason A. (Public Library of Science, 2023-09-20)

  OBJECTIVE :There is little prospective data to guide effective dosing for antibiotic prophylaxis during surgery requiring cardiopulmonary bypass (CPB). We aim to describe the effects of CPB on the population pharmacokinetics ...
• Maternal high-care and intensive care units in low- and middle-income countries 

  Rojas-Suarez, Jose; Paruk, Fathima (Elsevier, 2024-03)

  Despite notable advancements in minimizing maternal mortality during recent decades, a pronounced disparity persists between high-income nations and low-to middle-income countries (LMICs), particularly in intensive and ...
• Core competencies in critical care for general medical practitioners in South Africa : a Delphi study 

  Maasdorp, S.D.; Paruk, Fathima; De Vasconcellos, K.; Grion, C.; Joubert, I.; Joynt, G.M.; Kalafatis, N.; Lapinsky, S.E.; Lipman, J.; Malbrain, M.L.N.G.; Mrara, B.; Richards, G.A.; Spruyt, M.; Van der Merwe, E.; Vincent, J.L.; Van der Merwe, L.J. (Health and Medical Publishing Group, 2023-12)

  BACKGROUND : Despite a high burden of disease that requires critical care services, there are a limited number of intensivists in South Africa (SA). Medical practitioners at district and regional public sector hospitals ...
• Clinical efficacy and safety of a novel antifungal, Fosmanogepix, in patients with candidemia caused by Candida auris : results from a Phase 2 trial 

  Vazquez, Jose A.; Pappas, Peter G.; Boffard, Kenneth D.; Paruk, Fathima; Bien, Paul A.; Tawadrous, Margaret; Ople, Eric; Wedel, Pamela; Oborska, Iwona; Hodges, Michael R. (American Society for Microbiology, 2023-04)

  Fosmanogepix (FMGX), a novel antifungal available in intravenous (IV) and oral formulations, has broad-spectrum activity against pathogenic yeasts and molds, including fungi resistant to standard of care antifungals. This ...
• Decreased severity of disease during the first global Omicron variant COVID-19 outbreak in a large hospital in Tshwane, South Africa 

  Abdullah, Fareed; Myers, J.; Basu, Debashis; Tintinger, Gregory; Ueckermann, Veronica; Mathebula, M.; Ramlall, R.; Spoor, S.; De Villiers, T.; Van der Walt, Z.; Cloete, Jeane; Soma-Pillay, Priya; Rheeder, Paul; Paruk, Fathima; Engelbrecht, Adel; Lalloo, Vidya; Myburg, M.; Kistan, J.; Van Hougenhouck-Tulleken, Wesley G.; Boswell, Michael T.; Gray, G.; Welch, R.; Blumberg, Lucille Hellen; Jassat, W. (Elsevier, 2022-03)

  INTRODUCTION : The coronavirus disease 2019 (COVID-19) first reported in Wuhan, China in December 2019 is a global pandemic that is threatening the health and wellbeing of people worldwide. To date there have been more ...
• 'Acute kidney injury predictive models : advanced yet far from application in resource-constrained settings.' 

  Mrara, Busisiwe; Paruk, Fathima; Oladimeji, Olanrewaju (F1000 Research Ltd, 2022)

  Acute kidney injury (AKI) remains a significant cause of morbidity and mortality in hospitalized patients, particularly critically ill patients. It poses a public health challenge in resource-constrained settings due to ...
• Development and validation of a clinical prediction model of acute kidney injury in intensive care unit patients at a rural tertiary teaching hospital in South Africa : a study protocol 

  Mrara, Busisiwe; Paruk, Fathima; Sewani-Rusike, Constance; Oladimeji, Olanrewaju (BMJ Publishing Group, 2022-07)

  INTRODUCTION : Acute kidney injury (AKI) is a decline in renal function lasting hours to days. The rising global incidence of AKI, and associated costs of renal replacement therapy, is a public health priority. With the ...
• Quantifying the burden of the post-ICU syndrome in South Africa : a scoping review of evidence from the public health sector 

  Van der Merwe, E.; Paruk, Fathima (South African Medical Association, 2022-07)

  BACKGROUND. The post-ICU syndrome (PICS) comprises unexpected impairments in physical, cognitive, and mental health after intensive care unit (ICU) discharge, and is associated with a diminished health-related quality of ...
• Evaluating the usefulness of the estimated glomerular filtration rate for determination of imipenem dosage in critically ill patients 

  Mitton, Barend; Paruk, Fathima; Gous, A.; Chausse, J.; Milne, M.; Becker, Piet J.; Said, Mohamed (South African Medical Association, 2022-09)

  BACKGROUND. Antibiotic dosing in critically ill patients is complicated by variations in the pharmacokinetics of antibiotics in this group. The dosing of imipenem/cilastatin is usually determined by severity of illness and ...
• Long-stay medical-surgical intensive care unit patients in South Africa : quality of life and mortality 1 year after discharge 

  Van der Merwe, E.; Baker, D.; Sharp, G.; Van Niekerk, M. (Health and Medical Publishing Group, 2022-03)

  BACKGROUND. Although mortality is the primary measure of critical care outcome, the health-related quality of life (HRQOL) of survivors is often diminished. There is a paucity of South African research on HRQOL in intensive ...
• Predictors of in-hospital mortality among HIV-positive patients presenting with an acute illness to the emergency department 

  Laher, Abdullah E.; Paruk, Fathima; Venter, Willem Daniel Francois; Ayeni, Oluwatosin A.; Richards, Guy A. (Wiley, 2021-08)

  OBJECTIVES : Despite better access to antiretroviral therapy (ART) over recent years, HIV remains a major global cause of mortality. The present study aimed to identify predictors of in-hospital mortality among HIV-positive ...
• Development and internal validation of the HIV In-hospital mortality prediction (HIV-IMP) risk score 

  Laher, Abdullah E.; Paruk, Fathima; Venter, Willem Daniel Francois; Ayeni, Oluwatosin A.; Motara, Feroza; Moolla, Muhammed; Richards, Guy A. (Wiley, 2022-01)

  BACKGROUND : Despite advances in availability and access to antiretroviral therapy (ART), HIV still ranks as a major cause of global mortality. Hence, the aim of this study was to develop and internally validate a risk ...
• Antiretroviral therapy non-adherence among HIV- positive patients presenting to an emergency department in Johannesburg, South Africa: associations and reasons 

  Laher, Abdullah E.; Richards, G.A.; Paruk, Fathima; Venter, Willem Daniel Francois (Health and Medical Publishing Group, 2021-08)

  BACKGROUND. Suboptimal antiretroviral therapy (ART) adherence is associated with viral resistance, opportunistic infections and increased mortality. OBJECTIVES. To determine the rates of ART non-adherence and its associations, ...
• SARS-CoV-2 infection prevalence in healthcare workers and administrative and support staff: The first-wave experience at three academic hospitals in the Tshwane district of Gauteng Province, South Africa 

  Mdzinwa, Nasiphi; Voigt, M.; Janse van Rensburg, Dina Christina; Paruk, Fathima (Health and Medical Publishing Group, 2021-11)

  BACKGROUND : The availability of well and functional healthcare workers (HCWs) and support staff is pivotal to a country’s ability to manage the COVID-19 pandemic effectively. While HCWs have been identified as being at ...
• South African guidelines on the determination of death 

  Thomson, D.; Joubert, I.; De Vasconcellos, K.; Paruk, Fathima; Mokogong, S.; McCulloch, M.; Morrow, B.; Bakeer, D.; Rossouw, B.; Mdladla, N.; Richards, G.A.; Welkovics, N.; Levy, B.; Coetzee, Isabella M.; Spruyt, M.; Ahmed, N.; Gopalan, D. (Health and Medical Publishing Group, 2021-03)

  Death is a medical occurrence that has social, legal, religious and cultural consequences requiring common clinical standards for its diagnosis and legal regulation. This document compiled by the Critical Care Society of ...
• Is there a role for melatonin in the ICU? 

  Richards, Guy A.; Bentley, A.; Gopalan, P.D.; Brannigan, L.; Paruk, Fathima (Health and Medical Publishing Group, 2021-08)

  In the last decade, there have been significant developments in the understanding of the hormone melatonin in terms of its physiology, regulatory role and potential utility in various domains of clinical medicine. Melatonin’s ...
• Profile of presentation of HIV-positive patients to an emergency department in Johannesburg, South Africa 

  Laher, Abdullah E.; Venter, Willem Daniel Francois; Richards, Guy A.; Paruk, Fathima (AOSIS, 2021-01-29)

  BACKGROUND: Despite improved availability and better access to antiretroviral therapy (ART), approximately 36% of human immunodeficiency virus (HIV)-positive South Africans are still not virally suppressed. Objective: ...
• Positioning the role of qSOFA for screening and prognostication in critically ill medical and surgical patients with suspected sepsis 

  Paruk, Fathima (South African Medical Association, 2021)

  The global magnitude of sepsis coupled with the unacceptably high attendant mortality continues to fuel universal efforts to improve its early detection and the assessment of severity of disease in the pursuit of improving ...
• Predictors of prolonged hospital stay in HIV-positive patients presenting to the emergency department 

  Laher, Abdullah E.; Paruk, Fathima; Richards, Guy A.; Venter, Willem Daniel Francois (Public Library of Science, 2021-04)

  BACKGROUND: Prolonged hospitalization places a significant burden on healthcare resources. Compared to the general population, hospital length of stay (LOS) is generally longer in HIV-positive patients. We identified ...
• Clinical utility of the BioFire FilmArray Blood Culture Identification panel in the adjustment of empiric antimicrobial therapy in the critically ill septic patient 

  Rule, Roxanne; Paruk, Fathima; Becker, Piet J.; Neuhoff, Matthew; Chausse, Julian; Said, Mohamed (Public Library of Science, 2021-07)

  Sepsis and septic shock are key contributors to mortality in critically ill patients and thus prompt recognition and management thereof is central to achieving improved patient outcomes. Early initiation of appropriate ...

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