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Critical Care: Recent submissions
Now showing items 1-20 of 32
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(Public Library of Science, 2023-09-20)OBJECTIVE :There is little prospective data to guide effective dosing for antibiotic prophylaxis during surgery requiring cardiopulmonary bypass (CPB). We aim to describe the effects of CPB on the population pharmacokinetics ...
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(Elsevier, 2024-03)Despite notable advancements in minimizing maternal mortality during recent decades, a pronounced disparity persists between high-income nations and low-to middle-income countries (LMICs), particularly in intensive and ...
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(Health and Medical Publishing Group, 2023-12)BACKGROUND : Despite a high burden of disease that requires critical care services, there are a limited number of intensivists in South Africa (SA). Medical practitioners at district and regional public sector hospitals ...
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(American Society for Microbiology, 2023-04)Fosmanogepix (FMGX), a novel antifungal available in intravenous (IV) and oral formulations, has broad-spectrum activity against pathogenic yeasts and molds, including fungi resistant to standard of care antifungals. This ...
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(Elsevier, 2022-03)INTRODUCTION : The coronavirus disease 2019 (COVID-19) first reported in Wuhan, China in December 2019 is a global pandemic that is threatening the health and wellbeing of people worldwide. To date there have been more ...
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(F1000 Research Ltd, 2022)Acute kidney injury (AKI) remains a significant cause of morbidity and mortality in hospitalized patients, particularly critically ill patients. It poses a public health challenge in resource-constrained settings due to ...
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(BMJ Publishing Group, 2022-07)INTRODUCTION : Acute kidney injury (AKI) is a decline in renal function lasting hours to days. The rising global incidence of AKI, and associated costs of renal replacement therapy, is a public health priority. With the ...
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(South African Medical Association, 2022-07)BACKGROUND. The post-ICU syndrome (PICS) comprises unexpected impairments in physical, cognitive, and mental health after intensive care unit (ICU) discharge, and is associated with a diminished health-related quality of ...
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(South African Medical Association, 2022-09)BACKGROUND. Antibiotic dosing in critically ill patients is complicated by variations in the pharmacokinetics of antibiotics in this group. The dosing of imipenem/cilastatin is usually determined by severity of illness and ...
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(Health and Medical Publishing Group, 2022-03)BACKGROUND. Although mortality is the primary measure of critical care outcome, the health-related quality of life (HRQOL) of survivors is often diminished. There is a paucity of South African research on HRQOL in intensive ...
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(Wiley, 2021-08)OBJECTIVES : Despite better access to antiretroviral therapy (ART) over recent years, HIV remains a major global cause of mortality. The present study aimed to identify predictors of in-hospital mortality among HIV-positive ...
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Development and internal validation of the HIV In-hospital mortality prediction (HIV-IMP) risk score (Wiley, 2022-01)BACKGROUND : Despite advances in availability and access to antiretroviral therapy (ART), HIV still ranks as a major cause of global mortality. Hence, the aim of this study was to develop and internally validate a risk ...
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(Health and Medical Publishing Group, 2021-08)BACKGROUND. Suboptimal antiretroviral therapy (ART) adherence is associated with viral resistance, opportunistic infections and increased mortality. OBJECTIVES. To determine the rates of ART non-adherence and its associations, ...
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(Health and Medical Publishing Group, 2021-11)BACKGROUND : The availability of well and functional healthcare workers (HCWs) and support staff is pivotal to a country’s ability to manage the COVID-19 pandemic effectively. While HCWs have been identified as being at ...
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(Health and Medical Publishing Group, 2021-03)Death is a medical occurrence that has social, legal, religious and cultural consequences requiring common clinical standards for its diagnosis and legal regulation. This document compiled by the Critical Care Society of ...
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(Health and Medical Publishing Group, 2021-08)In the last decade, there have been significant developments in the understanding of the hormone melatonin in terms of its physiology, regulatory role and potential utility in various domains of clinical medicine. Melatonin’s ...
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(AOSIS, 2021-01-29)BACKGROUND: Despite improved availability and better access to antiretroviral therapy (ART), approximately 36% of human immunodeficiency virus (HIV)-positive South Africans are still not virally suppressed. Objective: ...
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(South African Medical Association, 2021)The global magnitude of sepsis coupled with the unacceptably high attendant mortality continues to fuel universal efforts to improve its early detection and the assessment of severity of disease in the pursuit of improving ...
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(Public Library of Science, 2021-04)BACKGROUND: Prolonged hospitalization places a significant burden on healthcare resources. Compared to the general population, hospital length of stay (LOS) is generally longer in HIV-positive patients. We identified ...
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(Public Library of Science, 2021-07)Sepsis and septic shock are key contributors to mortality in critically ill patients and thus prompt recognition and management thereof is central to achieving improved patient outcomes. Early initiation of appropriate ...
Now showing items 1-20 of 32