SARS-CoV-2 501Y.V2 escapes neutralization by South African COVID-19 donor plasma

Wibmer, Constantinos Kurt; Ayres, Frances; Hermanus, Tandile; Madzivhandila, Mashudu; Kgagudi, Prudence; Oosthuysen, Brent; Lambson, Bronwen E.; De Oliveira, Tulio; Vermeulen, Marion; Van der Berg, Karin; Rossouw, Theresa M.; Boswell, Michael T.; Ueckermann, Veronica; Meiring, Susan; Von Gottberg, Anne; Cohen, Cheryl; Morris, Lynn; Bhiman, Jinal N.; Moore, Penny L.

dc.contributor.author	Wibmer, Constantinos Kurt
dc.contributor.author	Ayres, Frances
dc.contributor.author	Hermanus, Tandile
dc.contributor.author	Madzivhandila, Mashudu
dc.contributor.author	Kgagudi, Prudence
dc.contributor.author	Oosthuysen, Brent
dc.contributor.author	Lambson, Bronwen E.
dc.contributor.author	De Oliveira, Tulio
dc.contributor.author	Vermeulen, Marion
dc.contributor.author	Van der Berg, Karin
dc.contributor.author	Rossouw, Theresa M.
dc.contributor.author	Boswell, Michael T.
dc.contributor.author	Ueckermann, Veronica
dc.contributor.author	Meiring, Susan
dc.contributor.author	Von Gottberg, Anne
dc.contributor.author	Cohen, Cheryl
dc.contributor.author	Morris, Lynn
dc.contributor.author	Bhiman, Jinal N.
dc.contributor.author	Moore, Penny L.
dc.date.accessioned	2021-04-07T07:26:39Z
dc.date.issued	2021-04
dc.description	Supplementary Information: Supplementary Figs. 1 and 2	en_ZA
dc.description.abstract	SARS-CoV-2 501Y.V2 (B.1.351), a novel lineage of coronavirus causing COVID-19, contains substitutions in two immunodominant domains of the spike protein. Here, we show that pseudovirus expressing 501Y.V2 spike protein completely escapes three classes of therapeutically relevant antibodies. This pseudovirus also exhibits substantial to complete escape from neutralization, but not binding, by convalescent plasma. These data highlight the prospect of reinfection with antigenically distinct variants and foreshadows reduced efficacy of spike-based vaccines.	en_ZA
dc.description.department	Immunology	en_ZA
dc.description.department	Internal Medicine	en_ZA
dc.description.embargo	2021-09-02
dc.description.librarian	hj2021	en_ZA
dc.description.sponsorship	The South African Medical Research Council, the Wellcome Trust, US Centers for Disease Control and Prevention and the ELMA South Africa Foundation.	en_ZA
dc.description.uri	http://www.nature.com/nm	en_ZA
dc.identifier.citation	Wibmer, C.K., Ayres, F., Hermanus, T. et al. SARS-CoV-2 501Y.V2 escapes neutralization by South African COVID-19 donor plasma. Nature Medicine 27, 622–625 (2021). https://doi.org/10.1038/s41591-021-01285-x.	en_ZA
dc.identifier.issn	1078-8956 (print)
dc.identifier.issn	1546-170X (online)
dc.identifier.other	10.1038/s41591-021-01285-x
dc.identifier.uri	http://hdl.handle.net/2263/79329
dc.language.iso	en	en_ZA
dc.publisher	Springer	en_ZA
dc.rights	© The Author(s), under exclusive licence to Springer Nature America, Inc. 2021	en_ZA
dc.subject	Infectious diseases	en_ZA
dc.subject	COVID-19 pandemic	en_ZA
dc.subject	Coronavirus disease 2019 (COVID-19)	en_ZA
dc.subject	Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)	en_ZA
dc.title	SARS-CoV-2 501Y.V2 escapes neutralization by South African COVID-19 donor plasma	en_ZA
dc.type	Postprint Article	en_ZA