Physico-chemical characterization of polyethylene glycol- conjugated betulinic acid

Mvango, Sindisiwe; Mthimkhulu, Nompumelelo; Fru, Pascaline Nanga; Pilcher, Lynne A.; Balogun, Mohammed O.

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dc.contributor.author	Mvango, Sindisiwe
dc.contributor.author	Mthimkhulu, Nompumelelo
dc.contributor.author	Fru, Pascaline Nanga
dc.contributor.author	Pilcher, Lynne A.
dc.contributor.author	Balogun, Mohammed O.
dc.date.accessioned	2021-02-16T13:56:26Z
dc.date.available	2021-02-16T13:56:26Z
dc.date.issued	2020-11
dc.description.abstract	Betulinic acid (BA) is a naturally occurring plant pentacyclic triterpenoid with activity against cancer and infectious diseases like malaria and AIDS. Its pharmacological activity is limited by low aqueous solubility and bioavailability. Attempts have been made to improve the solubility of BA by conjugation to the water-soluble polymer polyethylene glycol (PEG) but with very limited physico-chemical characterizations. This work presents physico-chemical characterizations of a PEG-BA conjugate using H NMR spectroscopy, electron microscopy, DLS and XRD. The NMR data showed successful conjugation through the formation of an amide bond with a 5% drug loading although the appearance of some chemical shift signals were solvent-dependent. TEM images showed a spherical morphology of the conjugate with average diameter of 59.58±4.47 nm.	en_ZA
dc.description.department	Chemistry	en_ZA
dc.description.librarian	pm2021	en_ZA
dc.description.uri	https://aip.scitation.org/journal/apc	en_ZA
dc.identifier.citation	Mvango, S., Mthimkhulu, N., Fru, P.N. et al. Physico-chemical characterization of polyethylene glycol- conjugated betulinic acid. AIP Conference Proceedings, vol. 2289, art. 020039, pp. 1-5 (2020); https://doi.org/10.1063/5.0028479.	en_ZA
dc.identifier.issn	0094-243X (print)
dc.identifier.issn	1551-7616 (online)
dc.identifier.other	10.1063/5.0028453
dc.identifier.uri	http://hdl.handle.net/2263/78694
dc.language.iso	en	en_ZA
dc.publisher	American Institute of Physics	en_ZA
dc.rights	© 2020 Author(s)	en_ZA
dc.subject	Pentacyclic triterpenoid	en_ZA
dc.subject	Herbal medicine	en_ZA
dc.subject	Remedy	en_ZA
dc.subject	Infectious diseases	en_ZA
dc.subject	Betulinic acid (BA)	en_ZA
dc.subject	Bioavailability	en_ZA
dc.subject	Solubility	en_ZA
dc.subject	Polyethylene glycol (PEG)	en_ZA
dc.subject	Electron microscopy	en_ZA
dc.subject	X-ray diffraction (XRD)	en_ZA
dc.subject	Nuclear magnetic resonance (NMR)	en_ZA
dc.title	Physico-chemical characterization of polyethylene glycol- conjugated betulinic acid	en_ZA
dc.type	Article	en_ZA