Assessment of the acute phase response in healthy and injured southern white rhinoceros (Ceratotherium simum simum)

Show simple item record

dc.contributor.author Hooijberg, Emma Henriette
dc.contributor.author Cray, Carolyn
dc.contributor.author Steenkamp, Gerhardus
dc.contributor.author Buss, Peter Erik
dc.contributor.author Goddard, Amelia
dc.contributor.author Miller, Michele
dc.date.accessioned 2020-10-09T10:34:08Z
dc.date.available 2020-10-09T10:34:08Z
dc.date.issued 2020-01-09
dc.description.abstract Acute phase reactants (APRs) have not been investigated in white rhinoceros (Ceratotherium simum). This study aimed to identify clinically useful APRs in this species. Reference intervals (RIs) were generated for albumin, fibrinogen, haptoglobin, iron and serum amyloid A (SAA) from 48 free-ranging animals, except for SAA (n = 23). APR concentrations between healthy animals and those with tissue injury (inflammation) (n = 30) were compared. Diagnostic performance was evaluated using receiver-operator characteristic (ROC) curve and logistic regression analyses. RIs were: albumin 18–31 g/L, fibrinogen 1.7–2.9 g/L, haptoglobin 1.0–4.3 g/L, iron 9.7–35.0 μmol/L, SAA <20 mg/L. Iron and albumin were lower and fibrinogen, haptoglobin and SAA higher in injured vs. healthy animals. Iron showed the best diagnostic accuracy followed by fibrinogen, albumin, haptoglobin and SAA. Iron ≤ 15.1 μmol/L and haptoglobin >4.7 g/L were significant predictors of inflammatory status and together correctly predicted the clinical status of 91% of cases. SAA > 20 mg/L had a specificity of 100%. In conclusion, albumin and iron are negative and fibrinogen, haptoglobin and SAA positive APRs in the white rhinoceros. The combination of iron and haptoglobin had an excellent diagnostic accuracy for detecting inflammation. en_ZA
dc.description.department Centre for Veterinary Wildlife Studies en_ZA
dc.description.department Companion Animal Clinical Studies en_ZA
dc.description.librarian am2020 en_ZA
dc.description.sponsorship The Health and Welfare Sector Education and Training Authority of South Africa, Tridelta Development Limited, the South African government through the South African Medical Research Council and the National Research Foundation. en_ZA
dc.description.uri https://www.frontiersin.org/journals/veterinary-science# en_ZA
dc.identifier.citation Hooijberg EH, Cray C, Steenkamp G, Buss P, Goddard A and Miller M (2020) Assessment of the Acute Phase Response in Healthy and Injured Southern White Rhinoceros (Ceratotherium simum simum). Frontiers in Veterinary Science 6:475. DOI: 10.3389/fvets.2019.00475. en_ZA
dc.identifier.issn 2297-1769 (online)
dc.identifier.other 10.3389/fvets.2019.00475
dc.identifier.uri http://hdl.handle.net/2263/76416
dc.language.iso en en_ZA
dc.publisher Frontiers Media en_ZA
dc.rights © 2020 Hooijberg, Cray, Steenkamp, Buss, Goddard andMiller. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). en_ZA
dc.subject Fibrinogen en_ZA
dc.subject Haptoglobin en_ZA
dc.subject Iron en_ZA
dc.subject White rhinoceros (Ceratotherium simum) en_ZA
dc.subject Acute phase reactant (APR) en_ZA
dc.subject Serum amyloid A (SAA) en_ZA
dc.subject Albumin en_ZA
dc.subject.other Veterinary science articles SDG-15 en_ZA
dc.subject.other SDG-15: Life on land
dc.title Assessment of the acute phase response in healthy and injured southern white rhinoceros (Ceratotherium simum simum) en_ZA
dc.type Article en_ZA


Files in this item

This item appears in the following Collection(s)

Show simple item record