We are excited to announce that the repository will soon undergo an upgrade, featuring a new look and feel along with several enhanced features to improve your experience. Please be on the lookout for further updates and announcements regarding the launch date. We appreciate your support and look forward to unveiling the improved platform soon.
dc.contributor.author | Hooijberg, Emma Henriette![]() |
|
dc.contributor.author | Cray, Carolyn![]() |
|
dc.contributor.author | Steenkamp, Gerhardus![]() |
|
dc.contributor.author | Buss, Peter Erik![]() |
|
dc.contributor.author | Goddard, Amelia![]() |
|
dc.contributor.author | Miller, Michele![]() |
|
dc.date.accessioned | 2020-10-09T10:34:08Z | |
dc.date.available | 2020-10-09T10:34:08Z | |
dc.date.issued | 2020-01-09 | |
dc.description.abstract | Acute phase reactants (APRs) have not been investigated in white rhinoceros (Ceratotherium simum). This study aimed to identify clinically useful APRs in this species. Reference intervals (RIs) were generated for albumin, fibrinogen, haptoglobin, iron and serum amyloid A (SAA) from 48 free-ranging animals, except for SAA (n = 23). APR concentrations between healthy animals and those with tissue injury (inflammation) (n = 30) were compared. Diagnostic performance was evaluated using receiver-operator characteristic (ROC) curve and logistic regression analyses. RIs were: albumin 18–31 g/L, fibrinogen 1.7–2.9 g/L, haptoglobin 1.0–4.3 g/L, iron 9.7–35.0 μmol/L, SAA <20 mg/L. Iron and albumin were lower and fibrinogen, haptoglobin and SAA higher in injured vs. healthy animals. Iron showed the best diagnostic accuracy followed by fibrinogen, albumin, haptoglobin and SAA. Iron ≤ 15.1 μmol/L and haptoglobin >4.7 g/L were significant predictors of inflammatory status and together correctly predicted the clinical status of 91% of cases. SAA > 20 mg/L had a specificity of 100%. In conclusion, albumin and iron are negative and fibrinogen, haptoglobin and SAA positive APRs in the white rhinoceros. The combination of iron and haptoglobin had an excellent diagnostic accuracy for detecting inflammation. | en_ZA |
dc.description.department | Centre for Veterinary Wildlife Studies | en_ZA |
dc.description.department | Companion Animal Clinical Studies | en_ZA |
dc.description.librarian | am2020 | en_ZA |
dc.description.sponsorship | The Health and Welfare Sector Education and Training Authority of South Africa, Tridelta Development Limited, the South African government through the South African Medical Research Council and the National Research Foundation. | en_ZA |
dc.description.uri | https://www.frontiersin.org/journals/veterinary-science# | en_ZA |
dc.identifier.citation | Hooijberg EH, Cray C, Steenkamp G, Buss P, Goddard A and Miller M (2020) Assessment of the Acute Phase Response in Healthy and Injured Southern White Rhinoceros (Ceratotherium simum simum). Frontiers in Veterinary Science 6:475. DOI: 10.3389/fvets.2019.00475. | en_ZA |
dc.identifier.issn | 2297-1769 (online) | |
dc.identifier.other | 10.3389/fvets.2019.00475 | |
dc.identifier.uri | http://hdl.handle.net/2263/76416 | |
dc.language.iso | en | en_ZA |
dc.publisher | Frontiers Media | en_ZA |
dc.rights | © 2020 Hooijberg, Cray, Steenkamp, Buss, Goddard andMiller. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). | en_ZA |
dc.subject | Fibrinogen | en_ZA |
dc.subject | Haptoglobin | en_ZA |
dc.subject | Iron | en_ZA |
dc.subject | White rhinoceros (Ceratotherium simum) | en_ZA |
dc.subject | Acute phase reactant (APR) | en_ZA |
dc.subject | Serum amyloid A (SAA) | en_ZA |
dc.subject | Albumin | en_ZA |
dc.subject.other | Veterinary science articles SDG-15 | en_ZA |
dc.subject.other | SDG-15: Life on land | |
dc.title | Assessment of the acute phase response in healthy and injured southern white rhinoceros (Ceratotherium simum simum) | en_ZA |
dc.type | Article | en_ZA |