The accuracy of preoperative serum CA-125 levels to predict lymph node metastasis in a population of South African women with endometrial carcinoma

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dc.contributor.author Hapsari, Kartika
dc.contributor.author Makin, J.D. (Jennifer Dianne)
dc.contributor.author Dreyer, Greta
dc.date.accessioned 2020-08-05T08:14:56Z
dc.date.available 2020-08-05T08:14:56Z
dc.date.issued 2019
dc.description.abstract BACKGROUND: The purpose of the study was to evaluate the predictive value of serum CA-125 levels in the preoperative assessment of endometrial carcinoma in a setting where late presentation is common. METHOD: This retrospective study evaluated women with pathologically proven endometrial carcinoma scheduled for surgery between January 2012 and January 2017, who had preoperative serum CA-125 test results. The association of CA-125 with a variety of histological factors was evaluated using Spearman’s correlation and receiver operator characteristic (ROC) curves to evaluate sensitivity and specificity. RESULTS: Fifty-eight patients were included in the study, 34 (58.6%) of whom were FIGO stage II–IV. Elevated CA 125 levels were significantly correlated with late FIGO stage (p < 0.001), myometrial invasion (p < 0.001) and lymph node metastases (p < 0.001). The most appropriate cut-off point of CA-125, where an increase in sensitivity was not associated with a fall-off in specificity, was 20 IU/ml, reaching a sensitivity of 90% and a specificity of 67% for detection of lymph node metastases. CONCLUSION: Among this group of women with endometrial cancer, the preoperative serum CA-125 level was associated with lymph node metastases and we found a CA-125 of 20 IU/ml or more to be predictive. These findings suggest that, among similar populations, CA-125 could be done preoperatively and could be used to determine the need for node dissection. Since our findings are from a small retrospective cohort, this should be validated in a prospective study on early stage disease. en_ZA
dc.description.department Obstetrics and Gynaecology en_ZA
dc.description.librarian pm2020 en_ZA
dc.description.uri https://medpharm.tandfonline.com/toc/ojgo20/current en_ZA
dc.identifier.citation Hapsari, K., Makin, J.D. & Greta, D. 2019, 'The accuracy of preoperative serum CA-125 levels to predict lymph node metastasis in a population of South African women with endometrial carcinoma', South African Journal of Gynaecological Oncology, vol. 11, no. 1, pp. 7–10. en_ZA
dc.identifier.issn 2074-2835 (print)
dc.identifier.issn 2220-105X (online)
dc.identifier.other 10.1080/20742835.2019.1603833
dc.identifier.uri http://hdl.handle.net/2263/75566
dc.language.iso en en_ZA
dc.publisher Medpharm Publications, NISC (Pty) and Cogent, Taylor and Francis Group en_ZA
dc.rights © 2019 The Author(s). Co-published by NISC Pty (Ltd) and Informa UK Limited, trading as Taylor & Francis Group. Creative Commons License [CC BY-NC 4.0]. en_ZA
dc.subject CA-125 en_ZA
dc.subject Endometrium carcinoma en_ZA
dc.subject Lymph nodes metastases en_ZA
dc.subject Surgical management en_ZA
dc.subject Receiver operator characteristic (ROC) en_ZA
dc.subject Predictive value en_ZA
dc.subject Preoperative assessment en_ZA
dc.subject Late presentation en_ZA
dc.title The accuracy of preoperative serum CA-125 levels to predict lymph node metastasis in a population of South African women with endometrial carcinoma en_ZA
dc.type Article en_ZA


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