Abstract:
Although the usage of electronic (e)-cigarettes (EC) and similar devices has gained in popularity
as an apparent smoking cessation strategy, serious concerns are emerging in relation to both the efficacy of
this strategy, as well as the inappropriate use of these devices. While the comparative safety of e-cigarettes
is based on the reasonable contention that the levels of inhaled toxicants present in the aerosols generated
by these devices are considerably lower than those present in tobacco smoke, the perception that they are
indeed relatively risk-free is being challenged on several fronts. Notwithstanding lack of convincing evidence
of efficacy as a superior smoking cessation strategy, foremost among emerging concerns is the increasing use
of electronic nicotine-delivery devices by young never-smokers. Other concerns include increasing levels
of sophistication in the design and capacity of these devices in relation to nicotine content and delivery, the
potential threat of manipulation of the contents of e-liquids, as well as other additives such as illicit drugs
and other potentially toxic agents that can be vaporised. These issues, together with the potential risks to
respiratory health, specifically “e-cigarette or vaping product use-associated lung injury” represent the major
thrusts of this review.
