Auditory neural function of normal hearing adults with type 2 diabetes mellitus

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dc.contributor.advisor Biagio, Leigh
dc.contributor.coadvisor Rheeder, Paul
dc.contributor.postgraduate Kruger, Lucresia
dc.date.accessioned 2019-07-08T09:47:02Z
dc.date.available 2019-07-08T09:47:02Z
dc.date.created 2019/04/10
dc.date.issued 2018
dc.description Dissertation (MA)--University of Pretoria, 2018.
dc.description.abstract Background: The prevalence of diabetes mellitus is growing worldwide. Type 2 Diabetes Mellitus (T2DM) can lead to damage to various organs by affecting the intricate nerve and blood vessel systems in the body caused by hyperglycaemia, including the auditory neural pathway. Purpose: This study aimed to assess the auditory neural function of adults with T2DM by means of Auditory Brainstem Responses (ABR) with various stimulation rates, presenting with normal behavioural audiometric thresholds. Research Design: Cross-sectional comparative study of ABR latencies and amplitudes and the impact of various stimulation rates in T2DM participants when compared to gender and age-matched controls without diabetes. Study Sample: Sixty participants, thirty with T2DM and 30 without T2DM were recruited and gave informed consent. The thirty T2DM participants aged 20-60 years were recruited from three clinics including two private and one public tertiary clinic. The control group consisted of thirty healthy age and gender-matched volunteers. Behavioural audiometry was performed to ensure a normal pure tone average (< 25 dB HL). Data collection and analysis: The Interacoustics Eclipse Auditory Evoked Potentials (AEP) system was used for the ABR measures which were analysed using linear mixed models. Data consisted of latencies and amplitudes of wave I, III and V and interpeak latencies of I-III, III-V and I-V of the 31.1 Hz rate. Wave V latencies and amplitudes for the 45.1 and 61.1 Hz stimulation rates were also measured. Results: Wave III latency at 31.1 was significantly delayed in those with T2DM compared to the control group (p<0.05). Participants with T2DM presented with prolonged wave V latencies at the faster stimulation rates than those without T2DM, but the shift was not statistically different between groups. Diabetes status had no moderating effect of wave V latency at the different stimulation rates. Conclusion: The results identified that the rate study was not affected by any confounding variables such as diabetes status and glucose level. However, the subclinical neurophysiological pathology, specifically at the level of the brainstem, as demonstrated by the delay in wave III, may be at least part of the reason for complaints relating to bilateral hearing difficulties in noise
dc.description.availability Unrestricted
dc.description.degree MA
dc.description.department Speech-Language Pathology and Audiology
dc.identifier.citation Kruger, L 2018, Auditory neural function of normal hearing adults with type 2 diabetes mellitus, MA Dissertation, University of Pretoria, Pretoria, viewed yymmdd <http://hdl.handle.net/2263/70615>
dc.identifier.other A2019
dc.identifier.uri http://hdl.handle.net/2263/70615
dc.language.iso en
dc.publisher University of Pretoria
dc.rights © 2019 University of Pretoria. All rights reserved. The copyright in this work vests in the University of Pretoria. No part of this work may be reproduced or transmitted in any form or by any means, without the prior written permission of the University of Pretoria.
dc.subject UCTD
dc.title Auditory neural function of normal hearing adults with type 2 diabetes mellitus
dc.type Dissertation


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