Assessment of acute kidney injury in canine parvovirus infection : comparison of kidney injury biomarkers with routine renal functional parameters

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dc.contributor.author Van den Berg, Marit Frederieke
dc.contributor.author Schoeman, Johan P.
dc.contributor.author Defauw, Pieter
dc.contributor.author Whitehead, Zandri
dc.contributor.author Breemersch, A.
dc.contributor.author Goethals, Klaartje
dc.contributor.author Daminet, Sylvie C.
dc.contributor.author Meyer, Evelyne
dc.date.accessioned 2019-06-24T12:58:46Z
dc.date.issued 2018-12
dc.description Preliminary results were presented as an Oral Abstract at the 27th Congress of the European College of Veterinary Internal Medicine – Companion Animals, Malta, 14th–16th September 2017. en_ZA
dc.description.abstract Dogs with naturally occurring canine parvovirus (CPV) infection are at risk of developing acute kidney injury (AKI) due to several factors, including severe dehydration, hypotension and sepsis. Serum creatinine (sCr) and serum urea are insensitive markers for the assessment of early kidney injury. Therefore, the aim of this study was to investigate potential kidney injury in dogs with CPV infection using both routine renal functional parameters and several kidney injury biomarkers. Twenty-two dogs with CPV infection were prospectively enrolled and compared with eight clinically healthy control dogs. Urinary immunoglobulin G (uIgG) and C-reactive protein (uCRP) were measured to document glomerular injury, whereas urinary retinol-binding protein (uRBP) and neutrophil gelatinase-associated lipocalin (uNGAL) served as markers for tubular injury. These biomarkers were compared to routine renal functional parameters, including sCr, serum urea, urinary protein:creatinine ratio (UPC) and urine specific gravity (USG). Dogs with CPV infection had significantly higher concentrations of uIgG, uCRP, uRBP and uNGAL compared to healthy dogs. In contrast, sCr was significantly lower in dogs with CPV infection compared to controls, while serum urea was not significantly different. UPC and USG were both significantly higher in CPV-infected dogs. This study demonstrated that dogs with CPV infection had evidence of AKI, which remained undetected by the routine functional markers sCr and serum urea, but was revealed by UPC, uIgG, uCRP, uRBP and uNGAL. These results emphasize the added value of novel urinary kidney injury biomarkers to detect canine patients at risk of developing AKI. en_ZA
dc.description.department Companion Animal Clinical Studies en_ZA
dc.description.embargo 2019-12-01
dc.description.librarian hj2019 en_ZA
dc.description.uri http://www.elsevier.com/locate/tvjl en_ZA
dc.identifier.citation Van den Berg, M.F., Schoeman, J.P., Defauw, P. et al. 2018, 'Assessment of acute kidney injury in canine parvovirus infection : comparison of kidney injury biomarkers with routine renal functional parameters', The Veterinary Journal, vol. 242, pp. 8-14. en_ZA
dc.identifier.issn 1090-0233
dc.identifier.other 10.1016/j.tvjl.2018.10.002
dc.identifier.uri http://hdl.handle.net/2263/70286
dc.language.iso en en_ZA
dc.publisher Elsevier en_ZA
dc.rights © 2018 Elsevier Ltd. All rights reserved. Notice : this is the author’s version of a work that was accepted for publication in The Veterinary Journal. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. A definitive version was subsequently published in The Veterinary Journal, vol. 242, pp. 8-14, 2019. doi : 10.1016/j.tvjl.2018.10.002. en_ZA
dc.subject Acute kidney injury (AKI) en_ZA
dc.subject Canine en_ZA
dc.subject Parvovirus en_ZA
dc.subject Urinary biomarkers en_ZA
dc.subject Canine parvovirus (CPV) en_ZA
dc.subject Dogs (Canis familiaris) en_ZA
dc.title Assessment of acute kidney injury in canine parvovirus infection : comparison of kidney injury biomarkers with routine renal functional parameters en_ZA
dc.type Postprint Article en_ZA


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