Abstract:
BACKGROUND : To report on imaging findings using 68Ga-PSMAHBED-
CC PET in a series of 19 breast carcinoma patients.
METHODS : 68Ga-PSMA-HBED-CC PET imaging results obtained
were compared to routinely performed staging examinations
and analyzed as to lesion location and progesterone
receptor status.
RESULTS : Out of 81 tumor lesions identified, 84% were identified
on 68Ga-PSMA-HBED-CC PET. 68Ga-PSMA-HBED-CC
SUVmean values of distant metastases proved significantly
higher (mean, 6.86, SD, 5.68) when compared to those of primary
or local recurrences (mean, 2.45, SD, 2.55, p = 0.04) or
involved lymph nodes (mean, 3.18, SD, 1.79, p = 0.011).
SUVmean values of progesterone receptor-positive lesions
proved not significantly different from progesterone receptornegative
lesions. SUV values derived from FDG PET/CT, available
in seven patients, and 68Ga-PSMA-HBED-CC PET/CT
imaging proved weakly correlated (r = 0.407, p= 0.015).
CONCLUSIONS : 68Ga-PSMA-HBED-CC PET/CT imaging in
breast carcinoma confirms the reported considerable variation
of PSMA expression on human solid tumors using
immunohistochemistry.
