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dc.contributor.author | Liebenberg, Rudolf![]() |
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dc.contributor.author | Van Heerden, Brigitte![]() |
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dc.contributor.author | Ehlers, Rene![]() |
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dc.contributor.author | Du Plessis, Ilse![]() |
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dc.contributor.author | Roos, J.L. (Johannes Louw)![]() |
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dc.date.accessioned | 2016-09-22T07:05:25Z | |
dc.date.issued | 2016-09 | |
dc.description.abstract | Consistent associations have been found between advanced paternal age and an increased risk of psychiatric disorders, such as schizophrenia in their offspring. This increase appears to be linear as paternal age increases. The present study investigates the relationship between early deviant behaviour in the first 10 years of life of patients as well as longer term functional outcome and paternal age in sporadic Afrikaner founder population cases of schizophrenia. This might improve our understanding of Paternal Age-Related Schizophrenia (PARS). Follow up psychiatric diagnosis was confirmed by the Diagnostic Interview for Genetic Studies (DIGS). An early deviant childhood behaviour semi-structured questionnaire and the Specific Level of Functioning Assessment (SLOF) were completed. From the logistic regression models fitted, a significant negative relationship was found between paternal age at birth and social dysfunction as early deviant behaviour.Additionally, regression analysis revealed a significant negative relationship between paternal age at birth and the SLOF for interpersonal relationships later in life. Early social dysfunction may represent a phenotypic trait for PARS. Further research is required to understand the relationship between early social dysfunction and deficits in interpersonal relationships later in life. | en_ZA |
dc.description.department | Psychiatry | en_ZA |
dc.description.department | Statistics | en_ZA |
dc.description.embargo | 2017-09-30 | |
dc.description.librarian | hb2016 | en_ZA |
dc.description.uri | http://www.elsevier.com/locate/psychres | en_ZA |
dc.identifier.citation | Liebenberg, R, Van Heerden, B, Ehlers, R, Du Plessis, I & Roos, JL 2016, 'Advancing paternal age at birth is associated with poorer social functioning earlier and later in life of schizophrenia patients in a founder population', Psychiatry Research, vol. 243, pp. 185-190 | en_ZA |
dc.identifier.issn | 0165-1781 (print) | |
dc.identifier.issn | 1872-7123 (online) | |
dc.identifier.other | 10.1016/j.psychres.2016.06.045 | |
dc.identifier.uri | http://hdl.handle.net/2263/56788 | |
dc.language.iso | en | en_ZA |
dc.publisher | Elsevier | en_ZA |
dc.rights | © 2016 Elsevier Ireland Ltd. All rights reserved. Notice : this is the author’s version of a work that was accepted for publication in Psychiatry Research. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Psychiatry Research, vol. 243, pp. 185-190, 2016. doi : 10.1016/j.psychres.2016.06.045. | en_ZA |
dc.subject | Paternal age-related schizophrenia (PARS) | en_ZA |
dc.subject | Early deviance | en_ZA |
dc.subject | Social dysfunction | en_ZA |
dc.subject | Functional outcome | en_ZA |
dc.subject | Interpersonal relationships | en_ZA |
dc.subject | Learning disabilities | en_ZA |
dc.title | Advancing paternal age at birth is associated with poorer social functioning earlier and later in life of schizophrenia patients in a founder population | en_ZA |
dc.type | Postprint Article | en_ZA |