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Tumour regression in mice after treatment with extracts of the bone marrow from cattle harbouring tick-borne infections
King, A.C.; De Kock, V.E.; Bigalke, R.D.; Cameron, Colin McKenzie; Gilchrist, Frances M.C.; Morren, A.J.; Verster, Anna J.M.; Verwoerd, Daniel Wynand; Walker, Jane B.
Complete regression of a transplantable fibrosarcoma of mice was induced in an average of 86% of animals receiving repeated subcutaneous injections of an extract of the bone marrow from cattle harbouring Babesia parasites. Extracts from cattle harbouring Theileria mutans produced regression of tumours in an average of 63% of the recipients. Splenic extracts from the same animals and bone marrow extracts from an anaplasmosis carrier were less effective. Bone marrow extracts from control animals known to be free from these infections did not enhance the survival of tumour-bearing mice.
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