dc.contributor.author |
Van Aardt, M.C. (Matthys Cornelis)
|
|
dc.contributor.author |
Dreyer, Greta
|
|
dc.contributor.author |
Snyman, Leon Cornelius
|
|
dc.contributor.author |
Richter, Karin Louise
|
|
dc.contributor.author |
Becker, P.
|
|
dc.contributor.author |
Mojaki, S.M.
|
|
dc.date.accessioned |
2016-07-05T10:00:44Z |
|
dc.date.available |
2016-07-05T10:00:44Z |
|
dc.date.issued |
2016-06 |
|
dc.description.abstract |
BACKGROUND. In Africa, data on the relationship between oncogenic human papillomavirus (HPV) types, immune status and cervical
preinvasive lesions are lacking.
METHODS. We investigated low-risk (lrHPV) and high-risk (hrHPV) HPV types in a cohort of women with cervical intraepithelial neoplasia
(CIN) II/III confirmed on histological examination, in an urban setting with a high prevalence of HIV infection.
RESULTS. Of 270 women with confirmed CIN II/III, 45 were HIV-negative and 225 HIV-positive. HIV-infected women had significantly
more HPV type infections, including all HPV (p<0.001) and hrHPV (p=0.014) types. The prevalences of one or more hrHPV type/s
were 93.3% and 92.9% in HIV-negative and positive patients, respectively. The most prevalent hrHPV type among HIV-negative women
was HPV 16, followed by HPV 52, 31, 35 and 58. Among HIV-positive women, HPV 16 was followed by HPV 58, 35, 51 and 52. Not yet
qualifying for highly active antiretroviral therapy (HAART) (CD4 count >350 cells/μL) or having received HAART for ≥12 months were
negatively associated with HPV 18, 33, 45, 51, 52, 59 and 82.
CONCLUSIONS. In South Africa, burdened by the HIV pandemic, high numbers of high- and low-risk HPV type infections are present in
women with cervical preneoplasia. HPV type distribution differs among varying levels of HIV-induced immune depletion. |
en_ZA |
dc.description.department |
Medical Virology |
en_ZA |
dc.description.department |
Obstetrics and Gynaecology |
en_ZA |
dc.description.librarian |
am2016 |
en_ZA |
dc.description.uri |
http://www.samj.org.za |
en_ZA |
dc.identifier.citation |
Van Aardt, MC, Dreyer, G, Snyman, LC, Richter, KL, Becker, P & Mojaki, SM 2016, 'Oncogenic and incidental HPV types associated with histologically confirmed cervical intraepithelial neoplasia in HIV-positive and HIV-negative South African women', South African Medical Journal, vol. 106, no. 6, pp. 617-622. |
en_ZA |
dc.identifier.issn |
0256-9574 (print) |
|
dc.identifier.issn |
2078-5135 (online) |
|
dc.identifier.other |
10.7196/SAMJ.2016.v106i6.10335 |
|
dc.identifier.uri |
http://hdl.handle.net/2263/53636 |
|
dc.language.iso |
en |
en_ZA |
dc.publisher |
Health and Medical Publishing Group |
en_ZA |
dc.rights |
© 2016 Health & Medical Publishing Group. This work is licensed under a Creative Commons Attribution-NonCommercial Works License (CC BY-NC 3.0). |
en_ZA |
dc.subject |
Africa |
en_ZA |
dc.subject |
Infections |
en_ZA |
dc.subject |
Human immunodeficiency virus (HIV) |
en_ZA |
dc.subject |
Human papillomavirus (HPV) |
en_ZA |
dc.title |
Oncogenic and incidental HPV types associated with histologically confirmed cervical intraepithelial neoplasia in HIV-positive and HIV-negative South African women |
en_ZA |
dc.type |
Article |
en_ZA |