Oncogenic and incidental HPV types associated with histologically confirmed cervical intraepithelial neoplasia in HIV-positive and HIV-negative South African women

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dc.contributor.author Van Aardt, M.C. (Matthys Cornelis)
dc.contributor.author Dreyer, Greta
dc.contributor.author Snyman, Leon Cornelius
dc.contributor.author Richter, Karin Louise
dc.contributor.author Becker, P.
dc.contributor.author Mojaki, S.M.
dc.date.accessioned 2016-07-05T10:00:44Z
dc.date.available 2016-07-05T10:00:44Z
dc.date.issued 2016-06
dc.description.abstract BACKGROUND. In Africa, data on the relationship between oncogenic human papillomavirus (HPV) types, immune status and cervical preinvasive lesions are lacking. METHODS. We investigated low-risk (lrHPV) and high-risk (hrHPV) HPV types in a cohort of women with cervical intraepithelial neoplasia (CIN) II/III confirmed on histological examination, in an urban setting with a high prevalence of HIV infection. RESULTS. Of 270 women with confirmed CIN II/III, 45 were HIV-negative and 225 HIV-positive. HIV-infected women had significantly more HPV type infections, including all HPV (p<0.001) and hrHPV (p=0.014) types. The prevalences of one or more hrHPV type/s were 93.3% and 92.9% in HIV-negative and positive patients, respectively. The most prevalent hrHPV type among HIV-negative women was HPV 16, followed by HPV 52, 31, 35 and 58. Among HIV-positive women, HPV 16 was followed by HPV 58, 35, 51 and 52. Not yet qualifying for highly active antiretroviral therapy (HAART) (CD4 count >350 cells/μL) or having received HAART for ≥12 months were negatively associated with HPV 18, 33, 45, 51, 52, 59 and 82. CONCLUSIONS. In South Africa, burdened by the HIV pandemic, high numbers of high- and low-risk HPV type infections are present in women with cervical preneoplasia. HPV type distribution differs among varying levels of HIV-induced immune depletion. en_ZA
dc.description.department Medical Virology en_ZA
dc.description.department Obstetrics and Gynaecology en_ZA
dc.description.librarian am2016 en_ZA
dc.description.uri http://www.samj.org.za en_ZA
dc.identifier.citation Van Aardt, MC, Dreyer, G, Snyman, LC, Richter, KL, Becker, P & Mojaki, SM 2016, 'Oncogenic and incidental HPV types associated with histologically confirmed cervical intraepithelial neoplasia in HIV-positive and HIV-negative South African women', South African Medical Journal, vol. 106, no. 6, pp. 617-622. en_ZA
dc.identifier.issn 0256-9574 (print)
dc.identifier.issn 2078-5135 (online)
dc.identifier.other 10.7196/SAMJ.2016.v106i6.10335
dc.identifier.uri http://hdl.handle.net/2263/53636
dc.language.iso en en_ZA
dc.publisher Health and Medical Publishing Group en_ZA
dc.rights © 2016 Health & Medical Publishing Group. This work is licensed under a Creative Commons Attribution-NonCommercial Works License (CC BY-NC 3.0). en_ZA
dc.subject Africa en_ZA
dc.subject Infections en_ZA
dc.subject Human immunodeficiency virus (HIV) en_ZA
dc.subject Human papillomavirus (HPV) en_ZA
dc.title Oncogenic and incidental HPV types associated with histologically confirmed cervical intraepithelial neoplasia in HIV-positive and HIV-negative South African women en_ZA
dc.type Article en_ZA


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