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dc.contributor.author | Gemechu, Dibaba Bayisa![]() |
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dc.contributor.author | Debusho, Legesse Kassa![]() |
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dc.contributor.author | Haines, Linda M.![]() |
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dc.date.accessioned | 2016-01-25T08:14:36Z | |
dc.date.available | 2016-01-25T08:14:36Z | |
dc.date.issued | 2015 | |
dc.description.abstract | Microarray experiments help scientists to study the expression level of thousands of genes simultaneously. These experiments have many design challenges, such as, for example, which mRNA samples should be co-hybridized together and which treatments should be labelled with which fluorescent dye. Therefore a carefully designed microarray experiment to obtain efficient and reliable data so as to ensure the precise estimate of comparisons of interest is required. The present paper is concerned with A- and D-optimal row-column designs for two-colour microarray experiments, with the array and dye effects treated as the column and row effects, respectively. Linear mixed effects models were used to describe experiments for which a comparison of all possible pairs of treatments is of particular interest by taking the arrays as random column effects. The results of this study show that the optimal row-column designs under the linear fixed effects model are not necessarily optimal under the linear mixed effects model setting. | en_ZA |
dc.description.librarian | am2015 | en_ZA |
dc.description.sponsorship | Grants from the National Research Foundation (NRF) through the Competitive Support for Unrated Researchers Programme (Reference: SUR20110629000019843 and Grant No: 80407) and the Incentive Funding for Rated Researchers Programme (Grant No: UID 85456), the University of Pretoria and the University of Cape Town. | en_ZA |
dc.description.uri | http://www.sastat.org.za/journal/information | en_ZA |
dc.description.uri | http://reference.sabinet.co.za/sa_epublication/sasj | en_ZA |
dc.identifier.citation | Gemechu, DB, Debusho, LK & Haines, LM 2015, 'A - and D-optional row-column designs for two-colour cDNA microarray experiments using linear mixed effects models', South African Statistical Journal, vol. 49, pp. 153-168. | en_ZA |
dc.identifier.issn | 0038-271X | |
dc.identifier.uri | http://hdl.handle.net/2263/51235 | |
dc.language.iso | en | en_ZA |
dc.publisher | South African Statistical Association | en_ZA |
dc.rights | South African Statistical Association | en_ZA |
dc.subject | A-optimal | en_ZA |
dc.subject | D-optimal | en_ZA |
dc.subject | Linear mixed effects model | en_ZA |
dc.subject | Microarray experiments | en_ZA |
dc.subject | Robust designs | en_ZA |
dc.subject | Row-column design | en_ZA |
dc.title | A- and D-optional row-column designs for two-colour cDNA microarray experiments using linear mixed effects models | en_ZA |
dc.type | Article | en_ZA |