Antimitotic drugs in the treatment of cancer

Janse van Vuuren, Rustelle; Visagie, M.H. (Michelle Helen); Theron, Anne Elisabeth; Joubert, Annie M.

dc.contributor.author	Janse van Vuuren, Rustelle
dc.contributor.author	Visagie, M.H. (Michelle Helen)
dc.contributor.author	Theron, Anne Elisabeth
dc.contributor.author	Joubert, Annie M.
dc.date.accessioned	2015-12-11T06:34:54Z
dc.date.available	2015-12-11T06:34:54Z
dc.date.issued	2015-12
dc.description.abstract	Cancer is a complex disease since it is adaptive in such a way that it can promote proliferation and invasion by means of an overactive cell cycle and in turn cellular division which is targeted by antimitotic drugs that are highly validated chemotherapy agents. However, antimitotic drug cytotoxicity to non-tumorigenic cells and multiple cancer resistance developed in response to drugs such as taxanes and vinca alkaloids are obstacles faced in both the clinical and basic research field to date. In this review, the classes of antimitotic compounds, their mechanisms of action and cancer cell resistance to chemotherapy and other limitations of current antimitotic compounds are highlighted, as well as the potential of novel 17-β estradiol analogs as cancer treatment.	en_ZA
dc.description.librarian	hb2015	en_ZA
dc.description.sponsorship	Medical Research Council of South Africa, the Research Committee of the Faculty of Health Sciences of the University of Pretoria, the Cancer association of South Africa and the National Research Foundation.	en_ZA
dc.description.uri	http://link.springer.com/journal/280	en_ZA
dc.identifier.citation	Van Vuuren, RJ, Visagie, MH, Theron, AE & Joubert, AM 2015, 'Antimitotic drugs in the treatment of cancer', Cancer Chemotherapy and Pharmacology, vol. 76, no. 6, pp. 1101-1112.	en_ZA
dc.identifier.issn	0344-5704 (print)
dc.identifier.issn	1432-0843 (online)
dc.identifier.other	10.1007/s00280-015-2903-8
dc.identifier.uri	http://hdl.handle.net/2263/51145
dc.language.iso	en	en_ZA
dc.publisher	SpringerOpen	en_ZA
dc.rights	© The Author(s) 2015. This article is published with open access at Springerlink.com. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/).	en_ZA
dc.subject	Taxanes	en_ZA
dc.subject	Epothilones	en_ZA
dc.subject	Vinca alkaloids	en_ZA
dc.subject	Estrogens	en_ZA
dc.subject	2-Methoxyestradiol (2ME2)	en_ZA
dc.title	Antimitotic drugs in the treatment of cancer	en_ZA
dc.type	Article	en_ZA