dc.contributor.author |
Boca, Madalina Brindusa
|
|
dc.contributor.author |
Pretorius, Etheresia
|
|
dc.contributor.author |
Kgaje, Christopher
|
|
dc.contributor.author |
Apostolides, Zeno
|
|
dc.date.accessioned |
2008-04-11T13:52:01Z |
|
dc.date.available |
2008-04-11T13:52:01Z |
|
dc.date.issued |
2008-03 |
|
dc.description.abstract |
The suitability of micellar electrokinetic chromatography for the simultaneous trace determination of several compounds (sulfamethoxazole, trimethoprim, sulfanilic acid, sulfanilamide, 3,4,5-trimethoxybenzoic acid and nonoxynol-9) was assessed. The mixture was separated within 14 min at an applied voltage of 22 kV by using 30 mM phosphate electrolyte, containing 10 mM SDS, adjusted to pH 7.8. Under optimized separation conditions acceptable levels of linearity, precision and accuracy were obtained for all compounds. The method could be used as part of a cleaning validation study when assaying trace levels of co-trimoxazole drug, some of its decomposition products and detergent in the swab samples collected from pharmaceutical manufacturing equipment, after cleaning. |
en |
dc.description.sponsorship |
The Specialty and Fine Chemicals Program, CSIR, South Africa is greatly acknowledged for providing the CE instrument. Furthermore, the first author would like to thank Roche Products (Pty) Ltd. Isando for partially sponsoring this work, and to Mr. Jan Grace of Chemetrix for providing technical assistance. |
en |
dc.format.extent |
247960 bytes |
|
dc.format.mimetype |
application/pdf |
|
dc.identifier.citation |
Boca, MB, Pretorius, E, Kgaje, C & Apostolides, Z 2008, 'Assessment of MEKC suitability for residue drug monitoring on pharmaceutical manufacturing equipment', Journal of Pharmaceutical and Biomedical Analysis, vol. 46, no. 4, pp. 631-638. [http://www.sciencedirect.com/science/journal/07317085] |
en |
dc.identifier.issn |
0731-7085 |
|
dc.identifier.other |
10.1016/j.jpba.2007.11.022 |
|
dc.identifier.uri |
http://hdl.handle.net/2263/4961 |
|
dc.language.iso |
en |
en |
dc.publisher |
Elsevier |
en |
dc.rights |
Elsevier |
en |
dc.subject |
3,4,5-Trimethoxybenzoic acid |
en |
dc.subject |
Antibacterial drug |
en |
dc.subject |
Cleaning validation |
en |
dc.subject |
Co-trimoxazole |
en |
dc.subject |
MEKC |
en |
dc.subject |
Nonoxynol-9 |
en |
dc.subject |
Sulfamethoxazole |
en |
dc.subject |
Sulfanilic acid |
en |
dc.subject |
Trimethoprim |
en |
dc.subject.lcsh |
Sulfamethoxazole |
|
dc.subject.lcsh |
Trimethoprim |
|
dc.subject.lcsh |
Nonoxynol-9 |
|
dc.subject.lcsh |
Co-trimoxazole |
|
dc.subject.mesh |
Chromatography, Micellar Electrokinetic Capillary |
|
dc.subject.mesh |
Sulfanilic Acids |
|
dc.subject.mesh |
sulfanilamide |
|
dc.subject.mesh |
3,4,5-trimethoxybenzoic acid |
|
dc.title |
Assessment of MEKC suitability for residue drug monitoring on pharmaceutical manufacturing equipment |
en |
dc.type |
Postprint Article |
en |