Assessment of MEKC suitability for residue drug monitoring on pharmaceutical manufacturing equipment

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dc.contributor.author Boca, Madalina Brindusa
dc.contributor.author Pretorius, Etheresia
dc.contributor.author Kgaje, Christopher
dc.contributor.author Apostolides, Zeno
dc.date.accessioned 2008-04-11T13:52:01Z
dc.date.available 2008-04-11T13:52:01Z
dc.date.issued 2008-03
dc.description.abstract The suitability of micellar electrokinetic chromatography for the simultaneous trace determination of several compounds (sulfamethoxazole, trimethoprim, sulfanilic acid, sulfanilamide, 3,4,5-trimethoxybenzoic acid and nonoxynol-9) was assessed. The mixture was separated within 14 min at an applied voltage of 22 kV by using 30 mM phosphate electrolyte, containing 10 mM SDS, adjusted to pH 7.8. Under optimized separation conditions acceptable levels of linearity, precision and accuracy were obtained for all compounds. The method could be used as part of a cleaning validation study when assaying trace levels of co-trimoxazole drug, some of its decomposition products and detergent in the swab samples collected from pharmaceutical manufacturing equipment, after cleaning. en
dc.description.sponsorship The Specialty and Fine Chemicals Program, CSIR, South Africa is greatly acknowledged for providing the CE instrument. Furthermore, the first author would like to thank Roche Products (Pty) Ltd. Isando for partially sponsoring this work, and to Mr. Jan Grace of Chemetrix for providing technical assistance. en
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dc.format.mimetype application/pdf
dc.identifier.citation Boca, MB, Pretorius, E, Kgaje, C & Apostolides, Z 2008, 'Assessment of MEKC suitability for residue drug monitoring on pharmaceutical manufacturing equipment', Journal of Pharmaceutical and Biomedical Analysis, vol. 46, no. 4, pp. 631-638. [http://www.sciencedirect.com/science/journal/07317085] en
dc.identifier.issn 0731-7085
dc.identifier.other 10.1016/j.jpba.2007.11.022
dc.identifier.uri http://hdl.handle.net/2263/4961
dc.language.iso en en
dc.publisher Elsevier en
dc.rights Elsevier en
dc.subject 3,4,5-Trimethoxybenzoic acid en
dc.subject Antibacterial drug en
dc.subject Cleaning validation en
dc.subject Co-trimoxazole en
dc.subject MEKC en
dc.subject Nonoxynol-9 en
dc.subject Sulfamethoxazole en
dc.subject Sulfanilic acid en
dc.subject Trimethoprim en
dc.subject.lcsh Sulfamethoxazole
dc.subject.lcsh Trimethoprim
dc.subject.lcsh Nonoxynol-9
dc.subject.lcsh Co-trimoxazole
dc.subject.mesh Chromatography, Micellar Electrokinetic Capillary
dc.subject.mesh Sulfanilic Acids
dc.subject.mesh sulfanilamide
dc.subject.mesh 3,4,5-trimethoxybenzoic acid
dc.title Assessment of MEKC suitability for residue drug monitoring on pharmaceutical manufacturing equipment en
dc.type Postprint Article en


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