Browsing Medical Oncology by Type "Postprint Article"

Now showing items 1-8 of 8

Acute megakaryoblastic leukaemia: light microscopy and scanning electron microscopy of blast cells

Masingi, Ntsakisi I.; Laher, Zaheer; Pretorius, Etheresia (Wiley, 2017-03)

A 60-year-old human immunodeficiency virus-positive woman presented with splenomegaly.
Breast cancer in low-middle income countries : abnormality in splicing and lack of targeted treatment options

Francies, Flavia Zita; Hull, Rodney; Khanyile, Richard; Dlamini, Zodwa (e-Century Publishing, 2020-05)

Breast cancer is a common malignancy among women worldwide. Regardless of the economic status of a country, breast cancer poses a burden in prevention, diagnosis and treatment. Developed countries such as the U.S. have ...
Combination of everolimus with trastuzumab plus paclitaxel as first-line treatment for patients with HER2-positive advanced breast cancer (BOLERO-1) : a phase 3, randomised, double-blind, multicentre trial

Hurvitz, Sara A.; Andre, Fabrice; Jiang, Zefei; Shao, Zhimin; Mano, Max S.; Neciosup, Silvia P.; Tseng, Ling-Min; Zhang, Qingyuan; Shen, Kunwei; Liu, Donggeng; Dreosti, Lydia M.; Burris, Howard A.; Toi, Masakazu; Buyse, Marc E.; Cabaribere, David; Lindsay, Mary-Ann; Rao, Shantha; Pacaud, Lida Bubuteishvili; Taran, Tetiana; Slamon, Dennis (Elsevier, 2015-07)

BACKGROUND : mTOR inhibition has been shown to reverse trastuzumab resistance from hyperactivated the PIK/AKT/mTOR pathway due to PTEN loss, by sensitizing PTEN-deficient tumors towards trastuzumab. The BOLERO-1 study ...
Expression analysis of RbBP6 in human cancers : a prospective biomarker

Mbita, Zukile; Hull, Rodney; Mbele, Mzwandile; Makhafola, Tshepiso Jan; Dlamini, Zodwa (Lippincott, Williams and Wilkins, 2019-09)

Retinoblastoma binding protein 6 (RBBP6) is a cancer-related protein that has been implicated in the regulation of cell cycle and apoptosis. RBBP6 isoform 1 has been demonstrated to interact with two tumour suppressors, ...
Genomics and splicing events of type II endometrial cancers in the black population : racial disparity, socioeconomic and geographical differences

Francies, Flavia Zita; Marima, Rahaba; Hull, Rodney; Molefi, Thulo; Dlamini, Zodwa (e-Century Publishing, 2020-10)

Endometrial cancer, also known as uterine cancer, is the most common gynaecological malignancy with burgeoning incidence and mortality rates globally. Racial disparity, socioeconomic and geographical differences are important ...
Is targeting dysregulation in apoptosis splice variants in Mycobacterium tuberculosis (MTB) host interactions and splicing factors resulting in immune evasion by MTB strategies a possibility?

Dlamini, Zodwa; Alaouna, Mohammed; Cholo, Moloko C.; Hull, Rodney (Elsevier, 2020-09)

Mycobacterium tuberculosis (Mtb), is one of the foremost organisms causing mortality in humans, and has been for most of human history. When faced with an infection the human immune system is ordinarily very competent in ...
Lapatinib with trastuzumab for HER2-positive early breast cancer (NeoALTTO) : survival outcomes of a randomised, open-label, multicentre, phase 3 trial and their association with pathological complete response

De Azambuja, Evandro; Holmes, Andrew P.; Piccart-Gebhart, Martine; Holmes, Eileen; Di Cosimo, Serena; Swaby, Ramona; Untch, Michael; Jackisch, Christian; Lang, Istvan; Smith, Ian; Boyle, Frances; Xu, Binghe; Barrios, Carlos H.; Perez, Edith A.; Azim Jr., Hatem A.; Kim, Sung-Bae; Kuemmel, Sherko; Huang, Chiun-Sheng; Vuylsteke, Peter; Hsieh, Ruey-Kuen; Gorbunova, Vera; Eniu, Alexandru; Dreosti, Lydia M.; Tavartkiladze, Natalia; Gelber, Richard D.; Eidtmann, Holger; Baselga, José (Elsevier, 2014-09)

BACKGROUND : We investigated whether the increase in pathological complete response (pCR) rates with neoadjuvant combination of lapatinib and trastuzumab in addition to weekly paclitaxel would translate into improved survival ...
Splicing machinery genomics events in acute myeloid leukaemia (AML) : in search for therapeutic targets, diagnostic and prognostic biomarkers

Dlamini, Zodwa; Shoba, Bonginkosi; Hull, Rodney (e-Century Publishing, 2020-09)

Acute myeloid leukemia (AML) is the most common form of acute leukaemia and has the highest mortality rate. Screening for mutations in patients with AML has shown that in many cases genes carrying mutations are involved ...

Now showing items 1-8 of 8

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