Pathogenesis of heartwater. I. Cowdria ruminantium in the lymph nodes of domestic ruminants

Abstract

The intracellular replication of Cowdria ruminantium (Cowdry, 1926) is described in reticulum cells of lymph nodes several days prior to the appearance of rickettsial colonies in vascular endothelial cells. This is suggestive of a developmental cycle of the parasite in the lymph nodes. The subinoculation of suspensions of these glands resulted in transmission of the disease.