Abstract:
In the international literature, the role of Ozone
(O3) in the advancement in alveolar bone healing in the
absence of bone pathology was not tested before. The
purpose of this study was to evaluate alveolar bone
regeneration after a bone defect was created and treated
with a single topical administration of O3. Alveolar bone
defects were created on five healthy chacma baboons. One
side of the maxilla and mandible was topically treated with
a single treatment of an O3/O2 mixture (3,5–4 % O3), while
the opposite sides were not treated and thus served as
control. Regeneration was measured radiologically, using a
standardized gray scale, as the increase in bone density in
the treatment area at 3 and 6 weeks post-operative and was
statistically analyzed using multivariate analysis of variance
(MANOVA). There were no significant differences in
densities observed between the O3/O2 mixture treatment
and the control (p[0.05). A single O3 treatment did not
increase alveolar bone healing over a 3- and 6-week period
in the mandible and the maxilla.
