OBJECTIVE : we aim to synthesize available evidence on the effectiveness of hormonal plus targeted therapies for post-menopausal women with hormone receptor-positive and HER2-negative advanced breast cancer.
DATA SOURCES ...
De Beer‑Brandon, Caroline R.; Van Rooijen, Agatha Johanna; Becker, Piet J.; Paruk, Fathima(SpringerOpen, 2024-05-22)
BACKGROUND : Failed extubation increases the intensive care unit (ICU) length of stay, hospital length of stay,
and financial costs and it reduces the patient’s functional ability. Avoiding failed extubation is of utmost ...
BACKGROUND : Many stroke survivors in low- and middle-income countries such as Ghana live with various degrees
of disabilities. Insight into the level of disability and its determinants in stroke survivors has become very ...
Boshielo, Patience Matshepo; Jansen van Rensburg, Audrey; Viljoen, Carel Thomas; Botha, Tanita; De Villiers, Christina Elizabeth; Ramagole, Dimakatso Althea; Seyani, Limbikani; Janse van Rensburg, Dina Christina(Taylor and Francis, 2025)
OBJECTIVES : Trail running is a popular off-road sport involving running in natural environments over various terrains, often in remote locations. This study aims to investigate the epidemiology and risk factors of injuries ...
Dysferlin-deficient limb girdle muscular dystrophy (LGMD R2), also referred to as dysferlinopathy, can be associated with respiratory muscle weakness as the disease progresses. Clinical practice guidelines recommend biennial ...
OBJECTIVE : This review aimed to systematically quantify the
association between pre-operative total prostate-specific
antigen (tPSA) and survivorship of prostate cancer (PCa).
METHODS : Data sources for the review ...
INTRODUCTION: Spinal health in children and adolescents
has global implications, impacting school attendance,
academic performance and physical activity. Effective
school-based interventions are essential for promoting
spinal ...
Ibeneme, Sam C.; Odoh, Eunice; Martins, Nweke; Ibeneme, Georgian C.(BioMed Central, 2024-12)
BACKGROUND: Falls are a common problem experienced by people living with HIV yet predictive models specific
to this population remain underdeveloped. We aimed to identify, assess and stratify the predictive strength of ...
OBJECTIVE: To determine the epidemiology and clinical
characteristics of match and training injuries among
football players at an academy in Ghana.
METHODS: In this prospective observational study, we
followed 80 youth ...
INTRODUCTION: Life satisfaction is a key indicator of
successful ageing and reflects well-being. There is
evidence of the association between life satisfaction and
health behaviours among older adults. Therefore, ...
OBJECTIVES :
To determine the incidence, severity, and nature of injuries sustained by female trail runners and investigate selected training variables as risk factors for injuries.
DESIGN :
Cross-sectional, retrospective ...
BACKGROUND :
Community reintegration is an important goal for people living with a spinal cord injury (SCI), and pain is suspected to limit reintegration due to its limitations in daily functioning, mood, and ...
BACKGROUND : Patellofemoral pain syndrome is a highly prevalent overuse knee injury in athletic populations associated with pain and functional limitations, exacerbated by activities such as running, pivoting, cycling, and ...
Human, Anri; Corten, Lieselotte; Lozano-Ray, Eleonora; Morrow, Brenda M.(AOSIS, 2024-08-08)
BACKGROUND : Progressive respiratory muscle weakness and ineffective cough contribute to
morbidity and mortality in children with neuromuscular disorders (NMD). Inspiratory
muscle training (IMT) aims to preserve or improve ...
Nwagha, Theresa Ukamaka; Ugwu, Angela Ogechukwu; Nweke, Martins C.(Makerere University Medical School, 2024-09)
BACKGROUND AND OBJECTIVES : Blood transfusion is an effective and proven treatment for some severe complications of sickle cell disease. Recurrent transfusions have put patients with sickle cell disease at risk of developing ...
MacMillan, Candice; Olivier, Benita; Viljoen, Carel Thomas; Janse van Rensburg, Dina Christina; Sewry, Nicola Ann(Springer, 2024-10)
BACKGROUND :
The influence of menstrual cycle phases (MCPs), menstrual irregularities (MI) and hormonal contraceptive (HC) use on injury among female athletes has been scrutinised. Existing systematic reviews investigating ...
BACKGROUND: Concussions in Rugby Union are common with an increased risk to adolescent players. Coaches are key to injury prevention and a greater understanding of their knowledge and sentiments may guide future initiatives. ...
INTRODUCTION: Chronic non-specific low back pain (CNLBP) is
among the most common musculoskeletal system conditions
reported worldwide; however, few studies are available from
low- and middle-income countries (LMICs). ...
Magida, Nontembiso; Yazbek, Mariatha; Thambura, Julius Muchui(Wiley, 2024-10)
Transformation reflects the government's engagement and policies in restructuring higher education to cultivate the country's communal economy. Higher education is challenged in providing tertiary education to students ...
STUDY DESIGN: Systematic review of Randomised controlled trials.
OBJECTIVES: With the increasing incidence of back pain among children and its untold implications to their future,
back education tailored in an effective ...