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Research Articles (Bioinformatics & Computational Biology Unit)
This collection contains some of the full text peer-reviewed/ refereed articles published by researchers from the Department of Biochemistry
Recent Submissions
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Sedibe, Moosa Mahmood; Rafiri, Matumelo A.; Dikane, Goitsemang Mahlomola Hendry; Achilonu, Matthew Chilaka; Nkosi, S'busiso Mfan'vele; Ngubane, Xolile Veronica; Pierneef, Rian
(Elsevier, 2024-02)
Artemisia afra is an aromatic shrub used as a herbal remedy in southern Africa for various disorders, including coughs, colds, influenza, and, most notably, for the prophylaxis and treatment of Plasmodium falciparum ...
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Khan, Anisa S.; Pierneef, Rian Ewald; Abebe, Woubit; Adesiyun, Abiodun Adewale
(Springer, 2023-12)
Please read abstract in the article.
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Mafuna, T.; Matle, I.; Magwedere, K.; Pierneef, Rian Ewald; Reva, Oleg N.
(American Society for Microbiology, 2022-09-06)
Listeria species (spp.) are contaminants that can survive in food, on equipment, and on food processing premises if appropriate hygiene measures are not used. Homologous stress tolerance genes, virulence gene clusters such ...
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Naidoo, Yashini; Valverde, Angel; Pierneef, Rian Ewald; Cowan, Don A.
(Springer, 2022-04)
Precipitation is one of the major constraints influencing the diversity, structure, and activity of soil microbial communities in desert ecosystems. However, the effect of changes in precipitation on soil microbial communities ...
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Ranketse, Mary; Hefer, Charles A.; Pierneef, Rian Ewald; Fourie, Gerda; Myburg, Alexander Andrew
(Springer, 2022-03)
Macadamia nuts are known globally for their high quality and economic value. Global macadamia commercial nut production amounts to 60,000 metric tonnes and is increasing steadily. South Africa is the leading producer with ...
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Khan, Anisa S.; Pierneef, Rian Ewald; Gonzalez-Escalona, Narjol; Maguire, Meghan; Georges, Karla; Abebe, Woubit; Adesiyun, Abiodun Adewale
(Elsevier, 2023-02)
This study was conducted to determine the phylogenies of Salmonella strains isolated from cross-sectional studies conducted at hatcheries, broiler farms, processing plants, and retail outlets (broiler production chain) in ...
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Mafuna, Thendo; Soma, P.; Tsotetsi‑Khambule, A.M.; Hefer, C.A.; Muchadeyi, F.C.; Thekisoe, O.M.M.; Pierneef, Rian Ewald
(Nature Research, 2021-03)
A metagenomic approach was used to study the gut microbiome of Haemonchus contortus feld strains
and that of its predilection site, the abomasum of Dohne Merino sheep. The abomasum contents
and H. contortus were collected ...
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Bezuidt, Keoagile Ignatius Oliver; Gomri, Mohamed A.; Pierneef, Rian Ewald; Van Goethem, Marc W.; Kharroub, Karima; Cowan, Don A.; Makhalanyane, Thulani Peter
(Genomic Standards Consortium, 2016-09-09)
The members of the genus Thermoactinomyces are known for their protein degradative capacities. Thermoactinomyces
sp. strain AS95 is a Gram-positive filamentous bacterium, isolated from moderately saline water in the ...
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Grando, Delphine; Ortet, Philippe; Joubert, Fourie; Marechal, Eric; Bastien, Olivier
(Bentham Science, 2009-03)
A configuration space of homologous protein sequences (or CSHP) has been recently constructed based on pairwise comparisons, with probabilities deduced from Z-value statistics (Monte Carlo methods applied to pairwise ...
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Ganesan, Hamilton; Rakitianskaia, A.S. (Anastassia Sergeevna); Davenport, Colin F.; Tummler, Burkhard; Reva, Oleg N.
(BioMed Central, 2008-08)
BACKGROUND: Data mining in large DNA sequences is a major challenge in microbial genomics and
bioinformatics. Oligonucleotide usage (OU) patterns provide a wealth of information for large scale sequence analysis and ...
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Burger, Pieter Buys; Birkholtz, Lyn-Marie; Joubert, Fourie; Haider, Nashya; Walter, Rolf D.; Louw, Abraham Izak
(Elsevier, 2007-02)
Spermidine synthase is currently considered as a promising drug target in the malaria parasite, Plasmodium falciparum, due to the vital role of spermidine in the activation of the eukaryotic translation initiation factor ...