Browsing Theses and Dissertations (Physiology) by Subject "antimitotic"

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Evaluation of a strategy based on multi-drug targeting of cancer proteins in breast cancer cell lines

Nortje, Evangeline (University of Pretoria, 2020)

Therapeutic inefficacy of conventional cancer treatment is a particular dilemma associated with metastatic triple negative breast cancer (TNBC), with patients still facing poor prognosis. The design and development of novel ...
In vitro signal transduction mechanism exerted by 2-ethyl-3-O-sulphamoyl-estra-1,3,5(10),15-tetraen-3-ol-17-one in combination with dichloroacetic acid on breast adenocarcinoma (MCF-7) and breast non-tumorigenic (MCF-12A) cells

Stander, Xiao Xing (University of Pretoria, 2014)

Most cancer cells rely on aerobic glycolysis to support the mitochondrial oxidative phosphorylation system (OXPHOS). The persistent oxic-anoxic cycle exerts selection pressures which lead to constitutive activation of ...

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