• The effect of aspirin and lipopolysaccharide binding protein on hypercoagulability induced by lipopolysaccharide 

  Sibanda, Sthembile Valencia (University of Pretoria, 2019)

  Inflammation is a well-known underlying cause in many diseases. Chronic inflammation has a role in a host of common and often deadly diseases, including Alzheimer’s disease, rheumatoid arthritis, cancer, type 2 diabetes, ...
• The effects of whole body electromyostimulation exercise training on physical fitness in middle aged sedentary females 

  Burbidge, Michael (University of Pretoria, 2019)

  The purpose of this study was to determine the effects of whole-body electromyostimulation (WB-EMS) augmented calisthenic training on physique, maximum strength, balance and aerobic endurance and compare said effects to ...
• Biomechanical investigations of coordination during initial acceleration in highly trained to world class sprinters 

  Donaldson, Byron John (University of Pretoria, 2023)

  Initial sprint acceleration is a complex and dynamic skill, requiring the application of large forces to propel the body forwards. Effective force application is achieved through the use of joint and segment rotations in ...
• A comparison of the risk profile for developing illness-related medical encounters in half- and ultra-marathon runners 

  Baker, Dean (University of Pretoria, 2023)

  Research comparing risk profiles for medical encounters in race entrants at distance running events is limited. The aim of this study was to determine and compare the risk profile for developing illness-related medical ...
• Between-session reliability of performance and asymmetry variables during lower limb strength tests and sport-specific tasks in netball players 

  Britz, Charne Beatrix (University of Pretoria, 2023)

  Title: Between-session reliability of performance and asymmetry variables during lower limb strength tests and sport-specific tasks in netball players Inter-limb asymmetry, the ratio that represents the performance ...
• Investigating clotting changes in patients from Steve Biko Academic Hospital with intracerebral haemorrhage by studying the viscoelastic and ultrastructural properties of whole blood. 

  Ferreira, Shene (University of Pretoria, 2023)

  Patients with intracerebral haemorrhage (ICH) have an increased risk of experiencing clotting changes when compared to healthy individuals, with recent research indicating that a bleeding event may enhance the prothrombotic ...
• Investigating the role of oxidative stress in apoptosis induced by a sulphamoylated estradiol analogue in breast cell lines 

  Lebelo, Maphuti Tebogo (University of Pretoria, 2020)

  2-Methoxyestradiol (2ME), a 17β-estradiol metabolite, exerts anticancer properties however, the compound was found to possess low bioavailability. This resulted in the in silico-design of 2ME analogues with a sulphamoyl ...
• Investigating lipopolysaccharide-induced inflammation in Sprague-Dawley rats on liver function with specific focus on coagulation factor production 

  Rathebe, Karabo (University of Pretoria, 2023)

  Neurodegenerative diseases, such as Parkinson’s disease (PD) and Alzheimer’s disease (AD), have long confounded the scientific and medical communities. The extensive research into these diseases, particularly AD has produced ...
• Association between head circumference and monocyte phenotype in neonates exposed and unexposed to HIV at Kalafong Provincial Tertiary Hospital 

  Sipsma, Iwan (University of Pretoria, 2023)

  It is well documented that children living with human immunodeficiency virus (HIV) do not perform as well as children not living with HIV on general cognitive tests, processing speed, and visual-spatial tasks, and are at ...
• Neopterin and neurophysiological measurements as markers of anxiety and stress 

  Cronje, Rouxzan (University of Pretoria, 2023)

  Background: Mental health is an increasing global crisis. It has large social, economic, and health costs, with stress and anxiety disorders accounting for a large portion of the impact. Biomarkers may help to improve the ...
• Investigation of the expression of pro-angiogenic markers in cutaneous tumours in vivo and in vitro 

  Nonxuba, Masibulele (University of Pretoria, 2023)

  Cutaneous tumours are common types of cancers that develop from the skin and account for 40% of the cases worldwide. In particular, melanomas and cutaneous haemangiomas are commonly occurring skin tumours that are characterised ...
• The epidemiology and associated risk factors for muscle strain injuries in endurance athletes 

  Kroon, Lize (University of Pretoria, 2023)

  Long-distance running continues to increase in popularity owing to its easy accessibility and people’s growing interest in disease prevention. Over the last 25 years, increasing participation in long-distance has been ...
• Assessing the role of the KISS1 receptor in breast cancer cell behaviour with the use of CRISPR-mediated gene editing 

  Marais, Alex Leah (University of Pretoria, 2023-03-03)

  The recent advancements in gene editing have provided scientists with a powerful tool for the investigation of the role of individual proteins in cellular physiology and disease. Gene editing was preceded by another powerful ...
• The effect of systemic lipopolysaccharides on the cardiovascular system in Sprague-Dawley rats 

  Tambwe, Isabella Gloria (University of Pretoria, 2021)

  Literature has shown that there is a link between cardiovascular disease and cognitive deterioration. Cardiovascular and neurodegenerative diseases both share risk factors that include age, elevated cholesterol levels and ...
• Evaluation of a strategy based on multi-drug targeting of cancer proteins in breast cancer cell lines 

  Nortje, Evangeline (University of Pretoria, 2020)

  Therapeutic inefficacy of conventional cancer treatment is a particular dilemma associated with metastatic triple negative breast cancer (TNBC), with patients still facing poor prognosis. The design and development of novel ...
• In vitro induction of the apoptotic intrinsic pathway via a new antimitotic agent 

  Wolmarans, Elize (University of Pretoria, 2014)

  Unique, in silico-designed compounds with possible anticancer properties were identified in our laboratory. 2-Ethyl-3-O-sulphamoyl-estra-1,3,5(10)16-tetraene (ESE-16), with potential carbonic anhydrase IX inhibiting activity, ...
• The association of methylglyoxal-adducts with kinetics and ultrastructure of fibrin clots in coronary artery disease patients with type 2 diabetes mellitus 

  Nxumalo, Mikateko (University of Pretoria, 2020-12-15)

  Background: Glycation influences the ultrastructure and clot kinetics of fibrin clots due to the post-translational modifications in fibrinogen. Methylglyoxal (MG) is used to measure the level of glycation which has been ...
• The role of the kisspeptin receptor, KISS1R, in breast cancer cell proliferation, invasion and migration. 

  Azubuike, Udochi Felicia (University of Pretoria, 2021-02-10)

  Kisspeptin receptor, also known as KISS1R, is the endogenous receptor for the ligand peptide, kisspeptin. It is a G-protein coupled receptor that couples through the Gαq/11 pathway. It has been shown that KISS1R activation ...
• Training load and athlete well-being in university female hockey players during a congested tournament 

  Swan, Justin (University of Pretoria, 2020)

  The monitoring of athlete workload is common practice within field-based team sports. Athlete monitoring is performed using both objective and subjective monitoring tools. Results from previous research investigating the ...
• Effects of gold nanoparticles on vascular endothelial growth factor-A-induced melanoma cell growth and angiogenesis 

  Matutule, Lebogang Johanna (University of Pretoria, 2020-11)

  Melanoma is a skin cancer that relies on angiogenesis for growth and progression. Angiogenesis is the growth of new vessels from existing vessels and follows a number of steps that include endothelial cell growth, migration ...

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