• Investigating the direct infection of ex vivo bone marrow-derived and peripheral blood-derived haematopoietic stem/progenitor cells by HIV-1 

  Mistry, Priyal (University of Pretoria, 2023)

  Human immunodeficiency virus (HIV-1) infection remains a significant global public health concern, particularly in sub-Saharan Africa where the majority of HIV infections are concentrated. HIV-1 is known to target the host ...
• Sodium, potassium adenosine triphosphatase as a potential target of the anti-tuberculosis agents, clofazimine and bedaquiline 

  Mmakola, Khomotso Madimetsa Shelboy (University of Pretoria, 2023)

  ABSTRACT BACKGROUND: Tuberculosis (TB) is a disease caused by the acid-fast bacterium, Mycobacterium tuberculosis (M. tuberculosis). It is currently the leading cause of morbidity and mortality worldwide due to a single ...
• The role of Solute Carrier Family 7 Member 8 (SLC7A8) in adipogenesis in vitro and in a murine model of obesity 

  Pitere, Reabetswe (University of Pretoria, 2023)

  Obesity is a pandemic affecting both adults and children with an increasing annual prevalence. Adipogenesis, a process in which adipocyte precursors differentiate into mature adipocytes, is considered an important process ...
• The effect of cigarette smoke extract on the activity of clarithromycin with anti-pseudomonal agents on growth and biofilm formation of Pseudomonas aeruginosa 

  Sekalo, Lebogang (University of Pretoria, 2023)

  The present study was undertaken with the initial objective of investigating the effects of six primary anti-pseudomonal antibiotics, namely amikacin, cefepime, ciprofloxacin, meropenem, piperacillin and tazobactam, on the ...
• Influence of mesenchymal stromal cells and 2-methoxyestradiol in a murine model of spontaneous mammary carcinoma 

  Peta, Kimberly Thando (University of Pretoria, 2023)

  Breast cancer (BC) is the most prevalent cancer in females and the leading cause of cancer deaths. Treatment options include mastectomy, chemotherapy, and radiotherapy. While these treatments can improve 5-year survival ...
• In vitro osteogenic differentiation of mesenchymal stem cells 

  Mollentze, Jamie (University of Pretoria, 2022)

  The use of adipose-derived stromal/stem cells (ASCs) continues to increase in the field of regenerative medicine and other clinical applications. Adipose tissue can be collected in a less invasive procedure, when compared ...
• Development of a high-throughput screening assay to evaluate compound libraries for the modulation of adipogenesis 

  Giles, Rachel (University of Pretoria, 2022)

  The aim of this project was to develop assays that will allow for high-throughput screening to monitor adipogenesis. Such an assay may be useful for the identification of potential drug targets during the process of ...
• Resistance and immune activation profiles in HIV-1 subtype C-infected subjects failing antiretroviral therapy 

  Malherbe, Glen Pierre (University of Pretoria, 2014)

  No abstract
• Isolation and characterization of the cytotoxicity, intracellular bioactivity and mechanism of antimycobacterial action of Euclea natalensis-derived naphthoquinones 

  Thaver, Veneesha (University of Pretoria, 2010)

  The major cause of HIV-related mortality in Sub-Saharan countries is pulmonary tuberculosis (TB), which is an escalating threat due to the emergence of multidrug resistant (MDR) and extremely multidrug resistant (XDR) TB. ...
• The roles of the potassium-uptake systems, Trk and Kdp, in the extracellular and intracellular growth of Mycobacterium tuberculosis 

  Osman, Ayman Gassim Elamin (University of Pretoria, 2020)

  In his thesis, The roles of the potassium-uptake systems, Trk and Kdp, in the extracellular and intracellular growth of Mycobacterium tuberculosis, Mr Osman investigated the roles of the major potassium-uptake transporters ...
• Optimising the efficacy of clofazimine against biofilm-encased Mycobacterium tuberculosis 

  Mashele, Sizeka Aubrey (University of Pretoria, 2020)

  Background: The chemotherapy of tuberculosis (TB) patients is administered for a six to nine- month period consisting of an intensive phase during the first two months with four primary anti- TB drugs, rifampicin (RMP), ...
• Hematopoietic stem and progenitor cell heterogeneity and susceptibility to HIV-1 

  Mellet, Juanita (University of Pretoria, 2019)

  Umbilical cord blood (UCB) is a rich source of hematopoietic stem and progenitor cells (HSPCs). There are however limitations to using UCB as a regular source for hematopoietic stem cell transplantation (HSCT). The number ...
• Characterisation of adipose-derived stromal cell heterogeneity 

  Wolmarans, Elize (University of Pretoria, 2019)

  Human adipose-derived stromal cells (hASCs) have gained increasing attention in the past decade as a potential cell therapeutic product. hASCs are classified as multipotent, fibroblast-like, plastic-adherent cells that can ...
• Effects of cigarette smoke condensate on clarithromycin-mediated inhibition of biofilm formation and related alterations in resistance gene expression by Streptococcus pneumonia 

  Matapa, Kgashane Given (University of Pretoria, 2019)

  Streptococcus pneumoniae (the pneumococcus) is a Gram-positive bacterium that frequently colonises the nasopharynx of healthy humans. In susceptible hosts, especially children under 5 years with underdeveloped immune systems ...
• Transcriptional analysis of the host response to HIV-1 infection in CD4+ T lymphocytes monocytes and macrophages 

  Wickham, Catherine Heather (University of Pretoria, 2019)

  The human immunodeficiency virus (HIV) is the causative agent of acquired immune deficiency syndrome (AIDS), a condition characterized by depletion of CD4+ T cells and other immune system dysfunctions. Due to its widespread ...
• The role of Pref-1 in in vitro adipogenic differenctiation of mesenchymal stromal/stem cells 

  Da Silva, Carina Corte-Real (University of Pretoria, 2019)

  Obesity is characterized by an excessive amount of body fat which can negatively affect health as it is a risk factor for various non-communicable diseases such as cardiovascular disease and diabetes, amongst others. A ...
• Investigating the homing and healing properties of adipose-derived mesenchymal stromal cells using a model of wound repair 

  Kallmeyer, Karlien (University of Pretoria, 2019)

  Adult mesenchymal stromal cells show promise therapeutically due to their multipotent differentiation capacity, immunomodulatory properties, paracrine signalling and ability to migrate to sites of injury. The potential use ...
• Functional characterisation of gonadotropin-releasing hormone-estrogen conjugates 

  Leijenaar, Stacey-Lee (University of Pretoria, 2019-11-12)

  Prostate cancer (PC) is the second most commonly occurring cancer in men, and the fourth most common commonly occurring cancer overall. Almost all PC begins in an androgen-dependent state with androgen deprivation therapy ...
• Evaluating the effects of HIV-1 infection on haematopoietic stem cell colony formation 

  Herd, Candice Lee (University of Pretoria, 2019)

  The dissertation describes the production and titration of molecular clones of HIV-1B and HIV-1C primary isolates, as well as the assessment of haematopoietic stem and progenitor cell function by colony-forming unit assay ...
• Human leukocyte antigen (HLA) genetic diversity in South African populations 

  Tshabalala, Mqondisi (University of Pretoria, 2018)

  There is documented evidence of high genetic diversity amongst African populations, but there is limited data on human leukocyte antigen (HLA) diversity in these populations. HLA genes are highly polymorphic, and encode ...

View more