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Theses and Dissertations (Chemical Pathology)
Recent Submissions
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(University of Pretoria, 2020)Senescent cells have been linked to age-related diseases and frailty. Their pathogenic effects are mediated by a group of cellular secretions called the senescence-associated secretory phenotype (SASP). Removal of senescent ...
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(University of Pretoria, 2023)Cervical cancer is the leading cause of cancer-related mortalities in South African women. Vitamin D and its metabolites exert anti-cancer actions in various cancers; however, few studies have explored the effects of vitamin ...
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(University of Pretoria, 2022)The sudden death (SD) of a young and healthy individual can be traumatic. Approximately 85% of all SD cases are of cardiac origin, a condition known as sudden cardiac death (SCD). Familial dilated cardiomyopathy (FDCM) ...
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(University of Pretoria, 2022)This research aims to analyse the KCNQ1 gene in sudden unexpected deaths in a young South African population, to better understand the prevalence of variations within this gene. The KCNQ1 gene is a potassium ion channel ...
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Analysis of the role of nuclear factor-kappa B in insulin resistance caused by antiretroviral drugs (University of Pretoria, 2020)Human immunodeficiency virus still remains the leading cause of death globally including women of child-bearing age. The rate of AIDS-related death has significantly declined since the introduction of antiretroviral ...
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(University of Pretoria, 2020)Cervical cancer is the fourth most common female malignancy worldwide and is substantively higher in low-income and middle-income countries. In South Africa, cervical cancer is a leading cause of mortality amongst women. ...
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(University of Pretoria, 2019)Sudden death can be defined as death from natural causes occurring instantaneous or within a few minutes after its cause (Merriam-Webster, 2019). It is globally considered as one of the leading causes of mortality and may ...
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(University of Pretoria, 2012-10-11)NT proBNP is a precursor peptide that is derived from proBNP a cardiac natriuretic peptide (NP), which is measured in plasma to assist with management of cardiac related conditions. The first aim of this study was to examine ...
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(University of Pretoria, 2009-12-09)The metabolism of absorbed xenobiotic compounds in humans results in a mixture of target compounds applicable for analysis, trapped in complex biological matrices. Gas chromatography-mass spectrometry (GC-MS) is a powerful ...
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(University of Pretoria, 2008-04-29)Tryptophan is metabolised along the kynurenine pathway under the influence of tryptophan 2,3 dioxygenase and indoleamine 2,3 dioxygenase. Quinolinic acid and kynurenine, two neuroactive metabolites of the kynurenine pathway ...
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(University of Pretoria, 2005-09-23)Please read the abstract in the section 00front of this document
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(University of Pretoria, 2007)Please read the abstract in the section front of this document
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(University of Pretoria, 2005-08-02)Please read the abstract in the section 00front of this document
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(University of Pretoria, 2011-02-17)Please read the abstract on page 3 in the dissertation.
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(University of Pretoria, 2006-03-13)The purpose of this study was to determine whether the methylation of nicotinamide to N-methylnicotinamide could discriminate between differences in methionine nutritional status, and by implication methylation capacity, ...
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(University of Pretoria, 2009-04-15)The endogenous catecholamines and their metabolites play an integral role in establishing the presence or absence of a suspected sympatho-adrenal tumor. Highly elevated metabolites excreted in the urine are indicative of ...
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(University of Pretoria, 2001)The primal aim of this thesis was to establish whether kinetic aspects of vitamin B6 metabolism predispose to earlier observed racial differences found in plasma pyridoxal-5'-phosphate (PLP). The active forms of vitamin ...