• Electrochemical reduction of Formic acid using an earth abundant catalyst 

  Ndlangamandla, Simphiwe (University of Pretoria, 2019-11)

  Copper is one of the most useful electrocatalysts for electrochemically converting CO2 to hydrocarbons and alcohols. Unfortunately, copper suffers from a lack of selectivity and efficiency. Earth-abundant electrocatalysts ...
• The design, synthesis and biological evaluation of novel compounds against biomarkers of Alzheimer’s disease 

  Van Greunen, Divan Gerald (University of Pretoria, 2019-06)

  Alzheimer’s disease (AD) is the most common neurodegenerative disease accounting for an estimated 60 – 80 % of dementia cases. The disease affected 5.5 million Americans older than 65 years in 2018 alone, and this number ...
• Synthesis, characterization and applications of polymer based conjugate materials for infectious diseases of poverty 

  Tshweu, Lesego Lovius (University of Pretoria, 2018-12)

  The major disease burden for the majority of the world’s population is due to infectious diseases. The most prevalent are HIV/AIDS, tuberculosis, lower respiratory tract infections, diarrhoeal diseases and malaria. In ...
• Molecular modelling and crystallographic investigation of novel synthetic cathinone 2-methyl-4'-(methylthio)-2-morpholinopropiophenone (MMMP) 

  Van Heerden, Lanzo Jacques (University of Pretoria, 2024-03-28)

  2-Methyl-4'-(methylthio)-2-morpholinopropiophenone (MMMP) is a highly modified synthetic cathinone derived from natural occurring cathinone, the main psychoactive alkaloid present in Catha edulis Forsk. or khat. Synthetic ...
• Synthesis of an 8-membered oxygen-containing benzo-fused heterocycle using flow technologies 

  Currie, Bernice Mercia (University of Pretoria, 2024-03)

  Flow chemistry has become an appealing alternative synthetic technology globally over the last few decades finding application in both academic and industrial laboratories driven largely by the fact that it commonly provides ...
• Anti-inflammatory and anti-diabetic properties of plant extracts and compounds from Scabiosa columbaria and Sclerocarya birrea 

  Ezeofor, Chidinma Christiana (University of Pretoria, 2023)

  Given that South Africa is home to around 10% of all flowering plant species known to humans, the country is blessed with an abundance of natural resources. About 24,000 plant species have yet to be fully uncovered for the ...
• The electrochemical reduction of CO2 to value-added products 

  Klopper, Reinard (University of Pretoria, 2024-02-23)

  Carbon dioxide is the fourth most abundant gas in the atmosphere making up 0.035 %. Carbon dioxide prevents heat from escaping into the outer space and is used by plants to make oxygen. The levels of carbon dioxide have ...
• Chemical analysis and survey of mycotoxins in South African produced grains with emphasis on those produced by stenocarpella maydis in maize 

  Meyer, Johanna Christina (University of Pretoria, 2024-02-20)

  During the latter half of the previous century, new mycotoxins were discovered as secondary metabolites of fungi in major grains before harvest. The prevalence of these toxic compounds and the negative health effects caused ...
• The semiochemistry of fruits as seen through the lens of Tephritid fruit flies and their parasitoids 

  Njurai Miano, Raphael (University of Pretoria, 2024-02)

  The tephritid fruit fly is a term well-known in fruit and vegetable production. Several techniques including the use of parasitoids have been deployed for fruit fly control. In Sub-Saharan Africa, Fopius arisanus (Sonan) ...
• Intermolecular bonding in water clusters from the molecular-wide and electron density-based (MOWED) perspective : a theoretical study 

  Zaaiman, Stéfan (University of Pretoria, 2023-12-14)

  Cooperativity is a strange phenomenon in water clusters, characterized by a non-linear decrease in the average electronic energy of a water molecule or hydrogen bond with an increase in cluster size. The main aim of this ...
• Thermal and Structural Characterization of Fipronil 

  Moyo, Dennis Simbarashe (University of Pretoria, 2023-06-13)

  Fipronil is a widely used insecticide which exerts selective toxicity towards the GABA receptors of insects and has no known pesticide resistance in target insects. This, in turn, has led to the increase in the usage of ...
• Porphyrin-based porous organic polymers enriched with Fe3O4  nanoparticles as electrosensors for the detection of endocrine disrupting chemicals in water 

  Berrange, Lu-Nita (University of Pretoria, 2023-11)

  Endocrine disrupting chemicals (EDCs) are commonly found in products such as pesticides, plastics, and pharmaceuticals. These chemicals are of significant concern due to their potential to disrupt the endocrine system, ...
• Development of analytical methods for N-nitrosamine disinfection byproducts in drinking water 

  Tyhali, Akhona (University of Pretoria, 2023-10-23)

  N-nitrosamines (NAs) are widely recognized as cancer-causing and genotoxic substances that emerge in water primarily as a result of chlorination or chloramination disinfection processes when nitrogen-containing compounds ...
• Evaluation of labelling mechanisms and analytical procedures for Ga-68 labelled peptides used in positron emission tomography 

  Marjanovic-Painter, Biljana (University of Pretoria, 2023)

  Nuclear Medicine imaging involves the monitoring of disease processes by using radioactive signals produced by radiopharmaceuticals (injected intravenously) to monitor the pharmacokinetic behaviour of compounds non-invasively ...
• A computational modelling study of chlorine dioxide and its role in water purification cycles 

  Misheer, Natasha (University of Pretoria, 2023)

  This study involves the computational investigation into the perceived reactivity of a group of sixty (60) sub- and extended- chlorine oxide species with the general formulae of CℓxOy applied to water purification. In order ...
• Development of a natural product library using hyphenated techniques and evaluation of its constituents as potential anti-cancer agents 

  Mc Millan, Patrick Matthew (University of Pretoria, 2023)

  Worldwide, cancer is among the most common public health issues with an estimated death toll in 2020 of close to 10 million individuals. Although cancer treatments are continuously improving as the use of personalised ...
• Use of hyphenated analytical techniques to isolate and characterise antiviral compounds against SARS-CoV-2 from South African medicinal plants 

  Luke, Invernizzi (University of Pretoria, 2023)

  The SARS-CoV-2 virus and, as an extension, the COVID-19 pandemic has led to unprecedented damage, economic hardship, and mental and/or physical strain on a global scale and highlighted humanity’s need for adequate pandemic ...
• Acid-mediated green synthesis and optimization of the calcium-terephthalate metal-organic framework derived from waste eggshells 

  Van Niekerk, Gizelle (University of Pretoria, 2023)

  Global plastic and food waste generation has climbed to unprecedented levels, inherently linked to exponential population growth since the 1950s accompanied by industrialization, urbanization and modernization. The reduction ...
• Synthesis, electronic structure and reactivity of rhodium(I) and iridium(I) bis(imino)acenaphthene complexes 

  Louw, Wynand Johannes (University of Pretoria, 2022)

  The bis(arylimino)acenaphthalene (BIAN) group of α-diimine compounds has shown promising electron sink behaviour and redox non-innocent activity as ligands to main group and transition metals. Here we present a series of ...
• Beneficiation of diamond mine residues for the synthesis of Mg containing compounds 

  Castleman, Barbara Ann (University of Pretoria, 2023)

  The aim of this study is to develop a process for the valorisation of diamond mine residues. This entailed a combination of thermochemical solid-solid reactions between the mine residues and ammonium sulphate, followed by ...

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