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Theses and Dissertations (Biochemistry): Recent submissions
Now showing items 41-60 of 171
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(University of Pretoria, 2018)Remarkable progress has been made in averting malaria cases and reducing malaria mortality globally. However, an incomplete understanding of the factors driving the continued transmission in pre-elimination settings ...
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(University of Pretoria, 2018)Malaria remains a leading health problem with an estimated 445 000 deaths occurring in 2016 of which the majority of deaths occurred in Africa. Currently, the World Health Organization recommends artemisinin-based combination ...
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(University of Pretoria, 2018-12)This doctoral study investigates three crucial aspects of malaria parasite development: 1) the atypical cell cycle that allows the rapid proliferation of asexual parasites; 2) the full molecular profile of gametocytogenesis ...
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(University of Pretoria, 2018)The Plasmodium falciparum parasite is the causative agent of the most severe form of malaria. The increase in resistance against the majority of antimalarial compounds underpins the need for the development of new antimalarial ...
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(University of Pretoria, 2017)There is a continuous and urgent need for novel antimalarial agents with new modes of action due to P. falciparum resistance development against most of the currently used therapeutics. In the search for a novel class of ...
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(University of Pretoria, 2017)Functional genomic tools can be used to interrogate unique features of parasite biology that could be marked for future intervention strategies. One such unique biological feature is the atypical cell cycle of the Plasmodium ...
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(University of Pretoria, 2017)The main focus of this research was to study in detail the selected plant growth promoting bacteria (PGPR) from Bacillus group. PGPR have been described as possible solution to the negative effects of chemicals fertilizers ...
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(University of Pretoria, 2017)The degradation of hemicellulose is a vital step in the efficient utilisation of plant biomass, an abundant source of carbohydrates in nature. Xylan, the most prevalent hemicellulose, is digested by xylanases and much work ...
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(University of Pretoria, 2015)Background: Metabolic complications resulting from the human immunodeficiency virus type 1 (HIV-1) and the acquired immunodeficiency syndrome (AIDS) are as common as the immune system disruption caused by the virus, but ...
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(University of Pretoria, 2017)First year students at tertiary institutions find themselves in an environment that is both exciting and intimidating. This study explores the dynamics of the classroom where biology students meet an experienced and a ...
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(University of Pretoria, 2017)Thiamine-phosphate kinase (or ATP:thiamine-phosphate phosphotransferase, ThiL) and homoserine (ThrB) kinases are essential to metabolism in Mycobacterium tuberculosis (Mtb). ThiL and ThrB respectively phosphorylate ...
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(University of Pretoria, 2017)Background: Metabolic disorders have been identified in patients infected with the human immunodeficiency virus (HIV). These disorders include lipodystrophy, wasting syndrome, cardiovascular disease and glucose intolerance. ...
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(University of Pretoria, 2017)The sustained control and elimination of malaria requires novel approaches to combat the emergence of drug resistance. Plasmodium falciparum causes the most lethal form of human malaria. Current therapeutics have shown ...
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(University of Pretoria, 2016)Enterotoxigenic Escherichia coli (ETEC) encompass a group of diverse bacterial pathogens that collectively cause hundreds of millions of diarrheal cases annually, mostly in developing countries. As part of its infection ...
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(University of Pretoria, 2016)The non-genealogical transfer of genetic information between prokaryotes is a frequent and omnipresent event. The acquisition of foreign genomic segments may aid organisms in adaptation to novel or extreme habitats with ...
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(University of Pretoria, 2016)Climate change is causing droughts affecting crop production on a global scale. Classical breeding and selection strategies for drought tolerant cultivars will help prevent crop losses. Plant breeders, for all crops, need ...
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(University of Pretoria, 2016-07-25)The ability of intracellular pathogens to invade and spread from non-phagocytic cell to another is an imperative mechanism broadly investigated in cellular biology. Listeria monocytogenes (Lm) –one example of intracellular ...
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(University of Pretoria, 2016)Background: HIV envelope (env) proteins are highly antigenic making them useful for detecting the immune response to natural infection. Envelope protein epitopes are not just virus derived but can be acquired from the host ...
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(University of Pretoria, 2015)In 1963 the study of marine natural products was just beginning and there were only a handful of public records with only one of these publications reporting a new compound. There has since been 9220 papers published, ...
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(University of Pretoria, 2015)
Now showing items 41-60 of 171