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Theses and Dissertations (Biochemistry): Recent submissions
Now showing items 21-40 of 171
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Structural and inhibition studies of thiamine monosphosphate kinase from Mycobacterium tuberculosis (University of Pretoria, 2020)Vitamin B1 is an indispensable co-factor for various enzymes inter alia in the Krebs cycle, pentose phosphate pathway, nucleotide and amino acid synthesis. Due to its importance in metabolism, proteins involved in the ...
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(University of Pretoria, 2018-12-06)The growing occurrence of antimicrobial resistance (AMR) is a global cause for concern due to the decreased availability of effective antimicrobial drugs. Therefore, treating resistant infections can become costly or even ...
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(University of Pretoria, 2020)Listeriosis is a food-borne disease caused by the gram-positive bacterium Listeria monocytogenes. In extreme cases, listeriosis can lead to sepsis and meningitis. The bacterium uses host actin cytoskeleton for its own ...
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(University of Pretoria, 2020)The development of multidrug resistant bacteria is currently a great concern, since the misuse of antibiotics have caused a strong selective pressure for these resistant bacteria and various treatment options are becoming ...
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(University of Pretoria, 2020-07-30)Background: Cancer is a genetic disorder characterized by an uncontrollable cell growth caused by a malfunction in the genes responsible for controlling the growth and division phases of the cell cycle. The disease can ...
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(University of Pretoria, 2020)Diabetes mellitus which is characterized by a high levels of blood glucose is a major source of mortality, morbidity and health costs worldwide. Major gaps exist in efforts to comprehend the burden nationally and globally, ...
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(University of Pretoria, 2020)In Africa, the grey leaf spot disease in maize is caused by the hemibiotrophic Dothideomycete Cercospora zeina. Dothideomycetes consist of many economically important phytopathogenic fungi. During infection of the host, ...
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(University of Pretoria, 2020-07)Candida albicans is a fungus found in the normal biota of humans, but in immuno-compromised individuals, C. albicans forms complex biofilms on the surface of medical prosthetics, skin, oral cavities, the urinary tract, ...
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(University of Pretoria, 2018)More people are aware of the problems with drugs and are reverting to herbal (plant) and over-the-counter medications. The conclusion made is the urgency to study new plants for antimicrobial activity. Various plant extracts ...
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(University of Pretoria, 2019)Malaria is a terrible disease caused by a protozoan parasite within the Plasmodium genus, claiming the lives of hundreds of thousands of people yearly, the majority of whom are children under the age of five. Of the five ...
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(University of Pretoria, 2018)The aim of this study was to create a genomic resource for a typical plant genome from Illumina short reads, using Psidium guajava as a case study. Here we present a bioinformatics approach to produce a de novo plant genome ...
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(University of Pretoria, 2019)The market value of molecular biology enzymes is growing rapidly, due to increasing applications in the Biotechnology industry. Such nucleic acid manipulating enzymes include polymerases, ligases, nucleases, phosphatases, ...
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(University of Pretoria, 2019)Accessible point of care diagnosis of Tuberculosis (TB) is an essential development to better manage the global epidemic that infects 10 million people annually. Current diagnostics are centralised, causing patient loss ...
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(University of Pretoria, 2018)Bacteriocins are post-translationally modified antimicrobial peptides of bacterial origin. Bacteriocins have been suggested for various applications including food preservation and alternates to antibiotic treatments. Over ...
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(University of Pretoria, 2018)Modern phylogenetic studies from the advancement of next generation sequencing can benefit from an analysis of complete genome sequences of various microorganisms. Evolutionary inferences based on genome scale analysis ...
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(University of Pretoria, 2019)The Plasmodium falciparum parasite, the major causative agent of malaria on the African continent, has evolved numerous cellular adaptations to effectively propagate its species. The parasite can proliferate asexually, ...
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(University of Pretoria, 2018)The success achieved in controlling malaria in recent years [1, 2], has caused a focal shift to elimination of the disease, with renewed interest in the discovery of novel chemotherapeutics with unique modes of action ...
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(University of Pretoria, 2018)Metagenomic approaches have revealed the complexity of environmental microbiomes and the advancement in whole genome sequencing showed a significant level of genetic heterogeneity on species level. It has become clear that ...
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(University of Pretoria, 2018)Tuberculosis (TB) is an infectious disease that is caused by the Mycobacterium tuberculosis (M.tb) species of bacteria. Despite this being discovered for over 100 years the disease continues to cause epidemics worldwide. ...
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(University of Pretoria, 2014)With the emergence of drug resistant bacteria, the need for new antimicrobial agents is growing. Antimicrobial peptides (AMPs) are natural antibiotics which have a broad spectrum of activity and also due to a great diversity ...
Now showing items 21-40 of 171