• The Antiatherogenic Potential of Two triterpenes from Protorhus longifolia stem bark (Benrh.) Engl. 

  Ramasia, Naleli Nthabiseng (University of Pretoria, 2024-01)

  Atherocardiovascular diseases (ACVDs) are considered among the major causes of death in South Africa and worldwide. Hypercholesterolemia, which is the main major risk factor of atherosclerosis, increases the occurrence of ...
• Inhibiting amylolytic enzymes by both acarbose and cellobiose as a prelude to treating type II diabetes mellitus 

  Maluleke, Kamogelo C (University of Pretoria, 2024-02-14)

  Inhibition of starch-degrading enzymes, α-amylase and α-glucosidase, provides a measure to ameliorate type II diabetes mellitus (T2D) by limiting the amount of glucose produced from dietary starch that would subsequently ...
• Exploring the mode of action of MMV1580843 against Plasmodium falciparum 

  Schultz, Dana Caitlin Jr (University of Pretoria, 2023-12-12)

  Although malaria is both preventable and curable, it is a parasitic disease with the highest fatality rate in history, causing over half a million deaths worldwide each year, with 95 % of the cases occurring in Africa. ...
• Development of a conditional gene knockout system to investigate the functional importance of regulatory genes in Plasmodium falciparum 

  Van Zyl, Christea (University of Pretoria, 2023-12-14)

  Malaria cases have surged in recent years, with the World Health Organization reporting 619 000 deaths in 2021. A recently approved malaria vaccine has been recommended for children younger than 5 years; this vaccine, ...
• Antibiofilm properties of selected Lactobacillus species and their mechanism of action against Listeria monocytogenes 

  Masebe, Reabetswe Dolly (University of Pretoria, 2022-01)

  The disastrous effects of the foodborne pathogen Listeria monocytogenes have been observed overtime by global listeriosis outbreaks claiming many lives. The spread of this pathogen is being reported at high levels with ...
• Non-compliance assessment and law enforcement efficacy in the eMalahleni Local Municipality Mpumalanga 

  Ngobeni, Vongani (University of Pretoria, 2021)

  Compliance refers to complying with legislation and/or licensing requirements, while regulation refers to the use of legislative powers to ensure compliance with the law (commercial law, 2016). It may also entail measures ...
• Chemically synthetic mycolic acids as vaccine adjuvants 

  Ranchod, Heena (University of Pretoria, 2014)

  No abstract
• Development and evaluation of a bi-enzymatic nitric oxide reduction system 

  Garny, Seike (University of Pretoria, 2013)

  Nitric oxide is a small diatomic molecule and is part of the nitrogen radical species. As a gas, it diffuses easily across cell membranes and is involved in numerous physiological processes and inflammation. This peculiar ...
• Transcriptional regulation underlying the quantitative genetic response of maize to grey leaf spot disease 

  Christie, Nanette (University of Pretoria, 2014)

  Cercospora zeina causes grey leaf spot (GLS), a yield-limiting disease on maize. The main objective of this study was to exploit maize gene expression data to dissect the quantitative disease response to C. zeina infection. ...
• Basal promoter landscape in Eucalyptus grandis : annotation of distal transcription start sites and core promoter usage 

  Van Jaarsveld, Ida CecIlia (University of Pretoria, 2014)

  Transcription is a complex biological phenomenon, whereby RNA is transcribed from single stranded template DNA by assembling targeted regulatory inputs at the promoter region. Transcription is regulated through many ...
• Reverse vaccinology based identification of anti- Rhipicephalus microplus vaccine candidates 

  Stutzer, Christian (University of Pretoria, 2013)

  The rapid geographic expansion of the cattle tick species, Rhipicephalus microplus, as well as the introduction of diseases into previously unaffected areas and the increased incidence of acaricide resistance in this species ...
• Investigating the anti-inflammatory properties of epigallocatechin gallate from green tea Camellia sinensis (L) O.Kuntze in mammalian innate immunity 

  Nyide, Nolwando Babalwa (University of Pretoria, 2020)

  Humans are hypersensitive to lipopolysaccharide, a gram-negative bacterial endotoxin that stimulates an inflammatory response by binding to the extracellular domain of TLR4 of innate immune cells. Through the MyD88-dependent ...
• Triazolyl Ru(II), Os(II), and Ir(III) complexes as potential HIV-1 entry inhibitors 

  Putterill, Brandon Marquand Fraser (University of Pretoria, 2021)

  Background: The human immunodeficiency virus (HIV) is the cause of the acquired immunodeficiency syndrome (AIDS). AIDS is fatal if not treated appropriately. Although there are treatment options for the infection, there ...
• In silico and in vitro inhibition of α- glucosidase and α-amylase by compounds from culinary herbs and spices, for possible treatment of type 2 diabetes 

  Tolmie, Morné (University of Pretoria, 2020)

  Diabetes is one of the largest health challenges of the 21st century and is amongst the top 10 causes of death globally. There is no cure for type 2 diabetes (T2DM) and the search for new and improved treatments is ongoing. ...
• Metabolomic markers for agronomic traits and their possible biochemical mechanisms in black tea Camellia sinensis (L.) O. Kuntze 

  Nyarukowa, Christopher (University of Pretoria, 2020-11-17)

  Climate change is causing droughts, which are affecting crop production globally, and disrupting plant metabolism. Due to the unpredictable natural droughts that occur, causing tea farmers significant losses in tea estates, ...
• The contribution of Plasmodium falciparum genetic diversity to differentiate drug response in gametocytes 

  Maboane, Suzan (University of Pretoria, 2020)

  Late-stage gametocytes of P. falciparum parasites are responsible for the ongoing human-to-mosquito transmission of malaria disease. To block transmission, novel gametocytocidal compounds are required. It is thus important ...
• Novel acid-labile and targeted nanoparticles as possible antimalarial drug delivery systems 

  Leshabane, Meta Kgaogelo (University of Pretoria, 2020)

  The multistage life cycle of malaria-causing P. falciparum is complex, making prevention and treatment difficult. As a result of resistance to many antimalarial drugs, novel compounds with unexplored targets are constantly ...
• Metabolomic analysis of maize (Zea mays&nbsp L.) seedlings treated with selected plant growth promoting rhizobacteria 

  Otukpa, Faith Obiye (University of Pretoria, 2019)

  Global food production has significantly increased mainly due to the use of high-yield crop varieties, fertilisers, fungicides and pesticides, and improved irrigation methods. Despite the increase in production, there has ...
• Exploring the evolution of drug resistance in mycobacterium using whole genome sequencing data 

  Muzondiwa, Dillon (University of Pretoria, 2019)

  Mycobacterium tuberculosis (Mtb) remains a global challenge that has been worsened by the emergence of drug resistant strains of Mtb. We used publicly available Next Generation Sequencing (NGS) and drug susceptibility (DST) ...
• Metabolic profiling for identification of potential biomarkers in potato tuber extracts associated with tolerance to Spongospora subterranea f. sp. subterranea infection 

  Modisane, Gontse Kehumile Joyce (University of Pretoria, 2019)

  Potatoes are popular and reliable crops all over the world. Unfortunately, its production is threatened by detrimental factors such as fungi, bacteria and viruses that attack potatoes during growth and storage. Among all ...

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